Publications by authors named "Ralph Holl"

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Development of Fragment-Based Inhibitors of the Bacterial Deacetylase LpxC with Low Nanomolar Activity.
Sebastian Mielniczuk, Katharina Hoff, Fady Baselious, Yunqi Li, Jörg Haupenthal, Ralph Holl

J Med Chem· October 2024

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Editorial: Emerging heterocycles as bioactive compounds.
Giovanna Li Petri, Ralph Holl, Virginia Spanò, Marilia Barreca, Ignazio Sardo

Front Chem· April 2023

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Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors.
Stefan Wimmer, Katharina Hoff, Benedikt Martin, Martin Grewer, Laura Denni, Ralph Holl

Bioorg Chem· February 2023

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Synthesis, biological evaluation, and molecular docking studies of deoxygenated C-glycosides as LpxC inhibitors.
Alexander Dreger, Katharina Hoff, Oriana Agoglitta, Emre F Bülbül, Jelena Melesina, Ralph Holl

Bioorg Chem· December 2021

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Pyrrolidine in Drug Discovery: A Versatile Scaffold for Novel Biologically Active Compounds.
Giovanna Li Petri, Maria Valeria Raimondi, Virginia Spanò, Ralph Holl, Paola Barraja

Top Curr Chem (Cham)· August 2021

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Antibacterial activity of xylose-derived LpxC inhibitors - Synthesis, biological evaluation and molecular docking studies.
Alexander Dreger, Katharina Hoff, Oriana Agoglitta, Sven-Kevin Hotop, Mark Brönstrup, Ralph Holl

Bioorg Chem· February 2021

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Bioactive pyrrole-based compounds with target selectivity.
Giovanna Li Petri, Virginia Spanò, Roberto Spatola, Ralph Holl, Maria Valeria Raimondi

Eur J Med Chem· December 2020

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Synthesis and biological evaluation of triazolyl-substituted benzyloxyacetohydroxamic acids as LpxC inhibitors.
Katharina Hoff, Sebastian Mielniczuk, Oriana Agoglitta, Maria Teresa Iorio, Manlio Caldara, Ralph Holl

Bioorg Med Chem· July 2020

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Structure-Based Design, Synthesis, and Biological Evaluation of Triazole-Based smHDAC8 Inhibitors.
Dmitrii V Kalinin, Sunit K Jana, Maxim Pfafenrot, Alokta Chakrabarti, Jelena Melesina, Ralph Holl

ChemMedChem· April 2020

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Proline-based hydroxamates targeting the zinc-dependent deacetylase LpxC: Synthesis, antibacterial properties, and docking studies.
Dmitrii V Kalinin, Oriana Agoglitta, Hélène Van de Vyver, Jelena Melesina, Stefan Wagner, Ralph Holl

Bioorg Med Chem· May 2019

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Chiral Pool Synthesis, Biological Evaluation and Molecular Docking Studies of C-Furanosidic LpxC Inhibitors.
Alexander Dreger, Omar Kharwb, Oriana Agoglitta, Emre F Bülbül, Jelena Melesina, Ralph Holl

ChemMedChem· April 2019

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Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
Martin Marek, Tajith B Shaik, Tino Heimburg, Alokta Chakrabarti, Julien Lancelot, Ralph Holl

J Med Chem· November 2018

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LpxC inhibitors: a patent review (2010-2016).
Dmitrii V Kalinin, Ralph Holl

Expert Opin Ther Pat· November 2017

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Insights into the Zinc-Dependent Deacetylase LpxC: Biochemical Properties and Inhibitor Design.
Dmitrii V Kalinin, Ralph Holl

Curr Top Med Chem· February 2017

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Novel Potent Proline-Based Metalloproteinase Inhibitors: Design, (Radio)Synthesis, and First in Vivo Evaluation as Radiotracers for Positron Emission Tomography.
Dmitrii V Kalinin, Stefan Wagner, Burkhard Riemann, Sven Hermann, Frederike Schmidt, Ralph Holl

J Med Chem· October 2016

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Synthesis and biological evaluation of enantiomerically pure glyceric acid derivatives as LpxC inhibitors.
Giovanni Tangherlini, Tullio Torregrossa, Oriana Agoglitta, Jens Köhler, Jelena Melesina, Ralph Holl

Bioorg Med Chem· March 2016

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Chiral pool synthesis and biological evaluation of C-furanosidic and acyclic LpxC inhibitors.
Hannes Müller, Valeria Gabrielli, Oriana Agoglitta, Ralph Holl

Eur J Med Chem· March 2016

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Synthesis, biological evaluation and molecular docking studies of benzyloxyacetohydroxamic acids as LpxC inhibitors.
Marina Szermerski, Jelena Melesina, Kanin Wichapong, Marius Löppenberg, Joachim Jose, Ralph Holl

Bioorg Med Chem· February 2014

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Synthesis and biological evaluation of flexible and conformationally constrained LpxC inhibitors.
Marius Löppenberg, Hannes Müller, Carla Pulina, Alberto Oddo, Mark Teese, Ralph Holl

Org Biomol Chem· September 2013

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Stereocontrolled synthesis of four diastereomeric C-aryl manno- and talofuranosides.
Elisa Ravarino, Sunit Kumar Jana, Roland Fröhlich, Ralph Holl

Carbohydr Res· November 2012

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Design and stereoselective synthesis of a C-aryl furanoside as a conformationally constrained CHIR-090 analogue.
Alberto Oddo, Ralph Holl

Carbohydr Res· October 2012

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Structure and function of an irreversible agonist-β(2) adrenoceptor complex.
Daniel M Rosenbaum, Cheng Zhang, Joseph A Lyons, Ralph Holl, David Aragao

Nature· January 2011

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Synthesis and pharmacological evaluation of SNC80 analogues with a bridged piperazine ring.
Ralph Holl, Bettina Jung, Dirk Schepmann, Hans-Ulrich Humpf, Renate Grünert

ChemMedChem· December 2009

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Structure-affinity-relationship study of bicyclic sigma receptor ligands.
Ralph Holl, Christian Geiger, Masakazu Nambo, Kenichiro Itami, Dirk Schepmann

Cent Nerv Syst Agents Med Chem· September 2009

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Dancing of the second aromatic residue around the 6,8-diazabicyclo[3.2.2]nonane framework: influence on sigma receptor affinity and cytotoxicity.
Ralph Holl, Dirk Schepmann, Roland Fröhlich, Renate Grünert, Patrick J Bednarski

J Med Chem· April 2009

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