Publications by authors named "Randy Miller"

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Response to reader comment on: "Comprehensive genotoxicity and carcinogenicity assessment of molnupiravir".
Patricia A Escobar, Zhanna Sobol, Randy R Miller, Sandrine Ferry-Martin, Angela Stermer

Toxicol Sci· March 2025

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Comprehensive genotoxicity and carcinogenicity assessment of molnupiravir.
Patricia A Escobar, Zhanna Sobol, Randy R Miller, Sandrine Ferry-Martin, Angela Stermer

Toxicol Sci· December 2024

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Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat : From Screening Impurity to Efficacy.
Jason W Skudlarek, Andrew J Cooke, Helen J Mitchell, Kerim Babaoglu, Anthony W Shaw, Randy R Miller

J Med Chem· September 2024

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Cerastecins inhibit membrane lipooligosaccharide transport in drug-resistant Acinetobacter baumannii.
Hao Wang, Andrii Ishchenko, Jason Skudlarek, Pamela Shen, Liudmila Dzhekieva, Randy R Miller

Nat Microbiol· May 2024

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Molnupiravir: Mechanism of action, clinical, and translational science.
Brian M Maas, Julie Strizki, Randy R Miller, Sushma Kumar, Michelle Brown

Clin Transl Sci· February 2024

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Short-course antibiotic therapy for pneumonia in the neonatal intensive care unit.
Zachery S Lewald, Pavel Prusakov, Jacqueline K Magers, Matthew J Kielt, Concepción de Alba Romero, Randy R Miller

J Perinatol· September 2023

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Short-course empiric antibiotic therapy for possible early-onset sepsis in the NICU.
Pablo J Sánchez, Pavel Prusakov, Concepción de Alba Romero, Elena Zamora-Flores, María Camila Reyes Escamilla, Randy R Miller

J Perinatol· June 2023

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Activity of Tricyclic Pyrrolopyrimidine Gyrase B Inhibitor against Mycobacterium abscessus.
Abdeldjalil Madani, Dereje A Negatu, Abdellatif El Marrouni, Randy R Miller, Christopher W Boyce

Antimicrob Agents Chemother· September 2022

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Understanding effect site pharmacology of uprifosbuvir, a hepatitis C virus nucleoside inhibitor: Case study of a multidisciplinary modeling approach in drug development.
Paul van den Berg, Wei Gao, Maurice J Ahsman, Leticia Arrington, Filippos Kesisoglou, Randy Miller

CPT Pharmacometrics Syst Pharmacol· July 2021

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Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization.
Randy R Miller, Maria Madeira, Harold B Wood, Wayne M Geissler, Conrad E Raab

J Med Chem· November 2020

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Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-induced Liver Injury.
James J Monroe, Keith Q Tanis, Alexei A Podtelezhnikov, Truyen Nguyen, Sam V Machotka, Randy R Miller

Toxicol Sci· September 2020

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A trial comparing continuous positive airway pressure (CPAP) devices in preterm infants.
Carl H Backes, Jennifer N Cooper, Jennifer L Notestine, Crystal M Alfred, Molly K Ball, Randy R Miller

J Perinatol· August 2020

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Reproducible Large-Scale Isolation of Exosomes from Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells and Their Application in Acute Kidney Injury.
Jun Ho Lee, Dae Hyun Ha, Hyeon-Kyu Go, Jinkwon Youn, Hyun-Keun Kim, Randy B Miller

Int J Mol Sci· July 2020

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Intraoperative Strategies for Minimal Manipulation of Autologous Adipose Tissue for Cell- and Tissue-Based Therapies: Concise Review.
Angelo Trivisonno, Robert W Alexander, Silvia Baldari, Steven R Cohen, Giuliana Di Rocco, Randy B Miller

Stem Cells Transl Med· December 2019

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Evaluating the efficacy of Seattle-PAP for the respiratory support of premature neonates: study protocol for a randomized controlled trial.
Carl H Backes, Jennifer L Notestine, Jane M Lamp, Jeanne C Balough, Allison M Notestine, Randy R Miller

Trials· January 2019

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Investigation of piperazine benzamides as human β adrenergic receptor agonists for the treatment of overactive bladder.
Bart H Harper, Liping Wang, Cheng Zhu, Nam F Kar, Bing Li, Randy R Miller

Bioorg Med Chem Lett· February 2017

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Design and Synthesis of P2-P4 Macrocycles Containing a Unique Spirocyclic Proline: A New Class of HCV NS3/4A Inhibitors.
Francisco Velázquez, Mariappan Chelliah, Martin Clasby, Zhuyan Guo, John Howe, Randy Miller

ACS Med Chem Lett· December 2016

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Discovery of N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia.
John S Debenham, Christina Madsen-Duggan, Matthew J Clements, Thomas F Walsh, Jeffrey T Kuethe, Randy R Miller

J Med Chem· December 2016

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Quality Improvement Initiative to Reduce the Necrotizing Enterocolitis Rate in Premature Infants.
Maria M Talavera, Gary Bixler, Corin Cozzi, James Dail, Randy R Miller

Pediatrics· May 2016

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Discovery of benzamides as potent human β3 adrenergic receptor agonists.
Cheng Zhu, Nam F Kar, Bing Li, Melissa Costa, Karen H Dingley, Randy R Miller

Bioorg Med Chem Lett· January 2016

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Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder.
Scott D Edmondson, Cheng Zhu, Nam Fung Kar, Jerry Di Salvo, Hiroshi Nagabukuro, Randy R Miller

J Med Chem· January 2016

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Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor.
Santhosh F Neelamkavil, Sony Agrawal, Thomas Bara, Chad Bennett, Sathesh Bhat, Randy Miller

ACS Med Chem Lett· January 2016

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Experimental and Theoretical Investigations of the Bromination of Phenols with β and γ Aliphatic Substituents, including Rings.
Jinsong Zhang, Xiao Chang, Erich C Bowman, Carter J Holt, Michael W Lodewyk, Randy M Miller

J Org Chem· September 2015

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The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization.
Harry R Chobanian, Yan Guo, Ping Liu, Thomas J Lanza, Marc Chioda, Randy Miller

Bioorg Med Chem· May 2012

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Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity.
Harry R Chobanian, Yan Guo, Ping Liu, Marc Chioda, Thomas J Lanza, Randy Miller

ACS Med Chem Lett· March 2012

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