Publications by authors named "Reid Huber"

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Discovery of 1'-(1-phenylcyclopropane-carbonyl)-3H-spiro[isobenzofuran-1,3'-pyrrolidin]-3-one as a novel steroid mimetic scaffold for the potent and tissue-specific inhibition of 11β-HSD1 using a scaffold-hopping approach.
Colin Zhang, Meizhong Xu, Chunhong He, Jincong Zhuo, David M Burns, Reid Huber

Bioorg Med Chem Lett· August 2022

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Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor.
Holly K Koblish, Liangxing Wu, Liang-Chuan S Wang, Phillip C C Liu, Richard Wynn, Reid Huber

Cancer Discov· June 2022

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Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor.
Liangxing Wu, Colin Zhang, Chunhong He, Dingquan Qian, Liang Lu, Reid Huber

J Med Chem· August 2021

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A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade.
Cecile Geuijen, Paul Tacken, Liang-Chuan Wang, Rinse Klooster, Pieter Fokko van Loo, Reid Huber

Nat Commun· July 2021

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INCB054828 (pemigatinib), a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays activity against genetically defined tumor models.
Phillip C C Liu, Holly Koblish, Liangxing Wu, Kevin Bowman, Sharon Diamond, Reid Huber

PLoS One· July 2020

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Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy.
Niu Shin, Matthew Stubbs, Holly Koblish, Eddy W Yue, Maxim Soloviev, Reid Huber

J Pharmacol Exp Ther· July 2020

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The Novel Bromodomain and Extraterminal Domain Inhibitor INCB054329 Induces Vulnerabilities in Myeloma Cells That Inform Rational Combination Strategies.
Matthew C Stubbs, Timothy C Burn, Richard Sparks, Thomas Maduskuie, Sharon Diamond, Reid Huber

Clin Cancer Res· January 2019

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Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies.
Holly Koblish, Yun-Long Li, Niu Shin, Leslie Hall, Qian Wang, Reid Huber

PLoS One· December 2018

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INCB040093 Is a Novel PI3K Inhibitor for the Treatment of B Cell Lymphoid Malignancies.
Niu Shin, Yun-Long Li, Song Mei, Kathy He Wang, Leslie Hall, Reid Huber

J Pharmacol Exp Ther· January 2018

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The effect of long-term ruxolitinib treatment on JAK2p.V617F allele burden in patients with myelofibrosis.
Michael Deininger, Jerald Radich, Timothy C Burn, Reid Huber, Dilan Paranagama

Blood· September 2015

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Validation of standards for quantitative assessment of JAK2 c.1849G>T (p.V617F) allele burden analysis in clinical samples.
Paul Collier, Keyur Patel, Paul Waeltz, Mark Rupar, Rajyalakshmi Luthra, Reid Huber

Genet Test Mol Biomarkers· May 2013

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The 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy.
Julio Rosenstock, Salomon Banarer, Vivian A Fonseca, Silvio E Inzucchi, William Sun, Reid Huber

Diabetes Care· July 2010

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Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells.
Phillip C C Liu, Xiangdong Liu, Yanlong Li, Maryanne Covington, Richard Wynn, Reid Huber

Cancer Biol Ther· June 2006

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CCR2 modulates inflammatory and metabolic effects of high-fat feeding.
Stuart P Weisberg, Deborah Hunter, Reid Huber, Jacob Lemieux, Sarah Slaymaker

J Clin Invest· January 2006

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Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist, INCB3344.
Carrie M Brodmerkel, Reid Huber, Maryanne Covington, Sharon Diamond, Leslie Hall

J Immunol· October 2005

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Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics.
Andrew P Combs, Eddy W Yue, Michael Bower, Paul J Ala, Brian Wayland, Reid Huber

J Med Chem· October 2005

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Induction of endogenous genes by peroxisome proliferator activated receptor alpha ligands in a human kidney cell line and in vivo.
Phillip C C Liu, Reid Huber, Mark D Stow, Karen L Schlingmann, Paul Collier

J Steroid Biochem Mol Biol· May 2003

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PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor.
Michael Fant, David L Weisoly, Massimo Cocchia, Reid Huber, Shaista Khan

Mol Reprod Dev· December 2002

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Dexamethasone and tumor necrosis factor-alpha act together to induce the cellular inhibitor of apoptosis-2 gene and prevent apoptosis in a variety of cell types.
Jeffrey C Webster, Reid M Huber, Rebecca L Hanson, Paul M Collier, Thomas F Haws

Endocrinology· October 2002

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Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters.
Reid M Huber, Kathleen Murphy, Bowman Miao, John R Link, Mark R Cunningham

Gene· May 2002

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Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia.
Joseph E Dinchuk, Richard J Focht, Jennifer A Kelley, Nancy L Henderson, Nina I Zolotarjova, Reid M Huber

J Biol Chem· April 2002

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Current themes in microarray experimental design and analysis.
William R Foster, Reid M Huber

Drug Discov Today· March 2002

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