Publications by authors named "Rene Smits"

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(+)-[F]Flubatine as a novel α4β2 nicotinic acetylcholine receptor PET ligand-results of the first-in-human brain imaging application in patients with β-amyloid PET-confirmed Alzheimer's disease and healthy controls.
Solveig Tiepolt, Georg-Alexander Becker, Stephan Wilke, Diego Cecchin, Michael Rullmann, René Smits

Eur J Nucl Med Mol Imaging· March 2021

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Image-Guided Development of Heterocyclic Sulfoxides as Ligands for Tau Neurofibrillary Tangles: From First-in-Man to Second-Generation Ligands.
Waqas Rafique, Vasko Kramer, Tania Pardo, René Smits, Mona M Spilhaug

ACS Omega· July 2018

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Cognitive correlates of α4β2 nicotinic acetylcholine receptors in mild Alzheimer's dementia.
Osama Sabri, Philipp M Meyer, Susanne Gräf, Swen Hesse, Stephan Wilke, Rene Smits

Brain· June 2018

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Exploring the Metabolism of (+)-[F]Flubatine in Vitro and in Vivo: LC-MS/MS Aided Identification of Radiometabolites in a Clinical PET Study.
Friedrich-Alexander Ludwig, Steffen Fischer, René Smits, Winnie Deuther-Conrad, Alexander Hoepping

Molecules· February 2018

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Procedures for the GMP-Compliant Production and Quality Control of [F]PSMA-1007: A Next Generation Radiofluorinated Tracer for the Detection of Prostate Cancer.
Jens Cardinale, René Martin, Yvonne Remde, Martin Schäfer, Antje Hienzsch, Rene Smits

Pharmaceuticals (Basel)· September 2017

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Radiation dosimetry of the αβ nicotinic receptor ligand (+)-[F]flubatine, comparing preclinical PET/MRI and PET/CT to first-in-human PET/CT results.
Mathias Kranz, Bernhard Sattler, Solveig Tiepolt, Stephan Wilke, Winnie Deuther-Conrad, René Smits

EJNMMI Phys· December 2016

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LC-MS Supported Studies on the in Vitro Metabolism of both Enantiomers of Flubatine and the in Vivo Metabolism of (+)-[(18)F]Flubatine-A Positron Emission Tomography Radioligand for Imaging α4β2 Nicotinic Acetylcholine Receptors.
Friedrich-Alexander Ludwig, René Smits, Steffen Fischer, Cornelius K Donat, Alexander Hoepping

Molecules· September 2016

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Enhanced copper-mediated (18)F-fluorination of aryl boronic esters provides eight radiotracers for PET applications.
Sean Preshlock, Samuel Calderwood, Stefan Verhoog, Matthew Tredwell, Mickael Huiban, René Smits

Chem Commun (Camb)· June 2016

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Development of a Novel Nonpeptidic (18)F-Labeled Radiotracer for in Vivo Imaging of Oxytocin Receptors with Positron Emission Tomography.
Barbara Wenzel, Jan Mollitor, Winnie Deuther-Conrad, Sladjana Dukic-Stefanovic, Mathias Kranz, Rene Smits

J Med Chem· March 2016

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First-in-human PET quantification study of cerebral α4β2* nicotinic acetylcholine receptors using the novel specific radioligand (-)-[(18)F]Flubatine.
Osama Sabri, Georg-Alexander Becker, Philipp M Meyer, Swen Hesse, Stephan Wilke, René Smits

Neuroimage· September 2015

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Internal dose assessment of (-)-18F-flubatine, comparing animal model datasets of mice and piglets with first-in-human results.
Bernhard Sattler, Mathias Kranz, Alexander Starke, Stephan Wilke, Cornelius K Donat, René Smits

J Nucl Med· November 2014

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Evaluation of metabolism, plasma protein binding and other biological parameters after administration of (-)-[(18)F]Flubatine in humans.
Marianne Patt, Georg A Becker, Udo Grossmann, Bernd Habermann, Andreas Schildan, René Smits

Nucl Med Biol· July 2014

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Synthesis and biological evaluation of both enantiomers of [(18)F]flubatine, promising radiotracers with fast kinetics for the imaging of α4β2-nicotinic acetylcholine receptors.
René Smits, Steffen Fischer, Achim Hiller, Winnie Deuther-Conrad, Barbara Wenzel

Bioorg Med Chem· January 2014

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Fully automated radiosynthesis of both enantiomers of [18F]Flubatine under GMP conditions for human application.
Marianne Patt, Andreas Schildan, Bernd Habermann, Steffen Fischer, Achim Hiller, René Smits

Appl Radiat Isot· October 2013

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Radiosynthesis of racemic and enantiomerically pure (-)-[18F]flubatine--a promising PET radiotracer for neuroimaging of α4β2 nicotinic acetylcholine receptors.
Steffen Fischer, Achim Hiller, René Smits, Alexander Hoepping, Uta Funke

Appl Radiat Isot· April 2013

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Direct one-step 18F-labeling of peptides via nucleophilic aromatic substitution.
Jessica Becaud, Linjing Mu, Mylène Karramkam, Pius A Schubiger, Simon M Ametamey, René Smits

Bioconjug Chem· December 2009

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Synthetic strategies to alpha-trifluoromethyl and alpha-difluoromethyl substituted alpha-amino acids.
René Smits, Cosimo Damiano Cadicamo, Klaus Burger, Beate Koksch

Chem Soc Rev· August 2008

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How C(alpha)-Fluoroalkyl amino acids and peptides interact with enzymes: studies concerning the influence on proteolytic stability, enzymatic resolution and peptide coupling.
René Smits, Beate Koksch

Curr Top Med Chem· October 2006

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