Publications by authors named "Ribo Guo"

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Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma.
Michael Visser, Julien P N Papillon, Michael Luzzio, Matthew J LaMarche, Jianmei Fan, Ribo Guo

J Med Chem· January 2024

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LXH254, a Potent and Selective ARAF-Sparing Inhibitor of BRAF and CRAF for the Treatment of MAPK-Driven Tumors.
Kelli-Ann Monaco, Scott Delach, Jing Yuan, Yuji Mishina, Paul Fordjour, Ribo Guo

Clin Cancer Res· April 2021

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Discovery of NVP-LEQ506, a second-generation inhibitor of smoothened.
Stefan Peukert, Feng He, Miao Dai, Rui Zhang, Yingchuan Sun, Ribo Guo

ChemMedChem· August 2013

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Targeting HSF1 sensitizes cancer cells to HSP90 inhibition.
Yaoyu Chen, Jinyun Chen, Alice Loo, Savina Jaeger, Linda Bagdasarian, Ribo Guo

Oncotarget· June 2013

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Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signaling.
Alix Scholer-Dahirel, Michael R Schlabach, Alice Loo, Linda Bagdasarian, Ronald Meyer, Ribo Guo

Proc Natl Acad Sci U S A· October 2011

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A crucial requirement for Hedgehog signaling in small cell lung cancer.
Kwon-Sik Park, Luciano G Martelotto, Martin Peifer, Martin L Sos, Anthony N Karnezis, Ribo Guo

Nat Med· October 2011

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Design and optimization of potent and orally bioavailable tetrahydronaphthalene Raf inhibitors.
Alexandra E Gould, Ruth Adams, Sharmila Adhikari, Kathleen Aertgeerts, Roushan Afroze, Ribo Guo

J Med Chem· March 2011

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Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.
Silvia Buonamici, Juliet Williams, Michael Morrissey, Anlai Wang, Ribo Guo

Sci Transl Med· September 2010

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Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist.
Shifeng Pan, Xu Wu, Jiqing Jiang, Wenqi Gao, Yongqin Wan, Ribo Guo

ACS Med Chem Lett· June 2010

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1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity.
Karen Miller-Moslin, Stefan Peukert, Rishi K Jain, Michael A McEwan, Rajesh Karki, Ribo Guo

J Med Chem· July 2009

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Bioinformatics-based discovery and characterization of an AKT-selective inhibitor 9-chloro-2-methylellipticinium acetate (CMEP) in breast cancer cells.
Manchao Zhang, Xueliang Fang, Hongpeng Liu, Ribo Guo, Xiaojin Wu

Cancer Lett· July 2007

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Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database.
Zaneta Nikolovska-Coleska, Liang Xu, Zengjian Hu, York Tomita, Peng Li, Ribo Guo

J Med Chem· May 2004

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Potentiating effect of distant sites in non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain.
Ya-Qiu Long, Ribo Guo, Juliet H Luo, Dajun Yang, Peter P Roller

Biochem Biophys Res Commun· October 2003

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Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells.
Manchao Zhang, Hongpeng Liu, Ribo Guo, Yan Ling, Xiaojin Wu

Biochem Pharmacol· July 2003

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LIGHT sensitizes IFNgamma-mediated apoptosis of MDA-MB-231 breast cancer cells leading to down-regulation of anti-apoptosis Bcl-2 family members.
Manchao Zhang, Ribo Guo, Yifan Zhai, Dajun Yang

Cancer Lett· June 2003

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Light stimulates IFNgamma-mediated intercellular adhesion molecule-1 upregulation of cancer cells.
Manchao Zhang, Ribo Guo, Yifan Zhai, Xin-Yuan Fu, Dajun Yang

Hum Immunol· April 2003

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Macrocyclization in the design of Grb2 SH2 domain-binding ligands exhibiting high potency in whole-cell systems.
Chang-Qing Wei, Yang Gao, Kyeong Lee, Ribo Guo, Bihua Li

J Med Chem· January 2003

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Development of a phosphatase-stable phosphotyrosyl mimetic suitably protected for the synthesis of high-affinity Grb2 SH2 domain-binding ligands.
Chang-Qing Wei, Bihua Li, Ribo Guo, Dajun Yang, Terrence R Burke

Bioorg Med Chem Lett· October 2002

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