Publications by authors named "Richard Barnard"

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PD-1 blockade enhances functional vaccine-induced HIV-1 CD8 T-cell responses in PWH receiving early ART.
Miguel Marin, Alba Ruiz, Dan Ouchi, Esther Jimenez-Moyano, Ruth Peña, Richard Barnard

EBioMedicine· December 2025

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Interleukin-10 contributes to reservoir establishment and persistence in SIV-infected macaques treated with antiretroviral therapy.
Justin Harper, Susan P Ribeiro, Chi Ngai Chan, Malika Aid, Claire Deleage, Richard Jo Barnard

J Clin Invest· April 2022

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Discovery of macrocyclic HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.
Wensheng Yu, James Fells, Dane Clausen, Jian Liu, Daniel J Klein, Richard J O Barnard

Bioorg Med Chem Lett· September 2021

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In Vitro Pharmacokinetic/Pharmacodynamic Modeling of HIV Latency Reversal by Novel HDAC Inhibitors Using an Automated Platform.
William Newhard, Munjal Patel, Jason Cassaday, Jeanine Ballard, Brian Squadroni, Richard Barnard

SLAS Discov· June 2021

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Discovery of Ethyl Ketone-Based Highly Selective HDACs 1, 2, 3 Inhibitors for HIV Latency Reactivation with Minimum Cellular Potency Serum Shift and Reduced hERG Activity.
Wensheng Yu, Jian Liu, Dane Clausen, Younong Yu, Joseph L Duffy, Richard J O Barnard

J Med Chem· April 2021

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Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction.
Douglas C Beshore, Gregory C Adam, Richard J O Barnard, Christine Burlein, Steven N Gallicchio

ACS Med Chem Lett· April 2021

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Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen.
Marina Bukhtiyarova, Erica M Cook, Paula J Hancock, Alan W Hruza, Anthony W Shaw, Richard J O Barnard

ACS Med Chem Lett· January 2021

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Discovery of Highly Selective and Potent HDAC3 Inhibitors Based on a 2-Substituted Benzamide Zinc Binding Group.
Jian Liu, Younong Yu, Joseph Kelly, Deyou Sha, Abdul-Basit Alhassan, Richard J O Barnard

ACS Med Chem Lett· December 2020

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Development of a selective HDAC inhibitor aimed at reactivating the HIV latent reservoir.
Dane J Clausen, Jian Liu, Wensheng Yu, Joseph L Duffy, Christine C Chung, Richard J O Barnard

Bioorg Med Chem Lett· September 2020

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Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.
Wensheng Yu, Jian Liu, Younong Yu, Vivian Zhang, Dane Clausen, Richard J O Barnard

Bioorg Med Chem Lett· July 2020

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Selective Class I HDAC Inhibitors Based on Aryl Ketone Zinc Binding Induce HIV-1 Protein for Clearance.
Jian Liu, Joseph Kelly, Wensheng Yu, Dane Clausen, Younong Yu, Richard J O Barnard

ACS Med Chem Lett· July 2020

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Cellular Gene Modulation of HIV-Infected CD4 T Cells in Response to Serial Treatment with the Histone Deacetylase Inhibitor Vorinostat.
Jill W Maxwell, Shane D Falcinelli, Alexey Nefedov, Corin Dorfmeier, Guoxin Wu, Richard J O Barnard

J Virol· June 2020

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Letermovir Resistance Analysis in a Clinical Trial of Cytomegalovirus Prophylaxis for Hematopoietic Stem Cell Transplant Recipients.
Cameron M Douglas, Richard Barnard, Daniel Holder, Randi Leavitt, Diane Levitan

J Infect Dis· March 2020

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Antiretroviral therapy alone versus antiretroviral therapy with a kick and kill approach, on measures of the HIV reservoir in participants with recent HIV infection (the RIVER trial): a phase 2, randomised trial.
Sarah Fidler, Wolfgang Stöhr, Matt Pace, Lucy Dorrell, Andrew Lever, Richard Barnard

Lancet· March 2020

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Differentiation into an Effector Memory Phenotype Potentiates HIV-1 Latency Reversal in CD4 T Cells.
Deanna A Kulpa, Aarthi Talla, Jessica H Brehm, Susan Pereira Ribeiro, Sally Yuan, Richard Barnard

J Virol· December 2019

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Antigen Production After Latency Reversal and Expression of Inhibitory Receptors in CD8+ T Cells Limit the Killing of HIV-1 Reactivated Cells.
Alba Ruiz, Oscar Blanch-Lombarte, Esther Jimenez-Moyano, Dan Ouchi, Beatriz Mothe, Richard Barnard

Front Immunol· October 2019

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Superinfection and cure of infected cells as mechanisms for hepatitis C virus adaptation and persistence.
Ruian Ke, Hui Li, Shuyi Wang, Wenge Ding, Ruy M Ribeiro, Richard J O Barnard

Proc Natl Acad Sci U S A· July 2018

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Total variation-based neutron computed tomography.
Richard C Barnard, Hassina Bilheux, Todd Toops, Eric Nafziger, Charles Finney

Rev Sci Instrum· May 2018

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Primer ID ultra-deep sequencing reveals dynamics of drug resistance-associated variants in breakthrough hepatitis C viruses: relevance to treatment outcome and resistance screening.
Richard Barnard, Abha Chopra, Ian James, John Blinco, Mark W Watson

Antivir Ther· February 2018

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CHEMGENIE: integration of chemogenomics data for applications in chemical biology.
Peter S Kutchukian, Charlie Chang, Sean J Fox, Erica Cook, Richard Barnard

Drug Discov Today· January 2018

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HDAC inhibition induces HIV-1 protein and enables immune-based clearance following latency reversal.
Guoxin Wu, Michael Swanson, Aarthi Talla, Donald Graham, Julie Strizki, Richard Jo Barnard

JCI Insight· August 2017

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Sensitivity analysis for dose deposition in radiotherapy via a Fokker-Planck model.
Richard C Barnard, Martin Frank, Kai Krycki

Math Med Biol· March 2017

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Identification of proximal biomarkers of PKC agonism and evaluation of their role in HIV reactivation.
Sai Vikram Vemula, Jill W Maxwell, Alexey Nefedov, Bang-Lin Wan, Justin Steve, Richard J Barnard

Antiviral Res· March 2017

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A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals.
Francesco Andrea Procopio, Rémi Fromentin, Deanna A Kulpa, Jessica H Brehm, Anne-Gaelle Bebin, Richard J O Barnard

EBioMedicine· August 2015

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Long-term follow-up of patients receiving boceprevir for treatment of chronic hepatitis C.
Anita Y M Howe, Jianmin Long, David Nickle, Richard Barnard, Seth Thompson

Antiviral Res· January 2015

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