Publications by authors named "Richard D DiMarchi"

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A once-daily GLP-1/GIP/glucagon receptor tri-agonist (NN1706) lowers body weight in rodents, monkeys and humans.
Brian Finan, Jonathan D Douros, Ronald Goldwater, Ann Maria Kruse Hansen, Julie B Hjerpsted, Richard D DiMarchi

Mol Metab· June 2025

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GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice.
Robert M Gutgesell, Ahmed Khalil, Arkadiusz Liskiewicz, Gandhari Maity-Kumar, Aaron Novikoff, Richard D DiMarchi

Nat Metab· June 2025

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Publisher Correction: GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice.
Robert M Gutgesell, Ahmed Khalil, Arkadiusz Liskiewicz, Gandhari Maity-Kumar, Aaron Novikoff, Richard D DiMarchi

Nat Metab· June 2025

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Glucose-dependent insulinotropic polypeptide (GIP).
Timo D Müller, Alice Adriaenssens, Bo Ahrén, Matthias Blüher, Andreas L Birkenfeld, Richard D DiMarchi

Mol Metab· May 2025

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Superior metabolic improvement of polycystic ovary syndrome traits after GLP1-based multi-agonist therapy.
Miguel A Sánchez-Garrido, Víctor Serrano-López, Francisco Ruiz-Pino, María Jesús Vázquez, Andrea Rodríguez-Martín, Richard D DiMarchi

Nat Commun· October 2024

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Correction: GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease.
Stephan Sachs, Anna Götz, Brian Finan, Annette Feuchtinger, Richard D DiMarchi

Cardiovasc Diabetol· September 2024

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Transforming obesity: The advancement of multi-receptor drugs.
Christine M Kusminski, Diego Perez-Tilve, Timo D Müller, Richard D DiMarchi, Matthias H Tschöp

Cell· July 2024

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Toward once-monthly insulin therapy synergy in two pharmacokinetic protractors: Fc-conjugation and fatty acid acylation.
Alexander N Zaykov, Vasily M Gelfanov, Tina M Tagmose, Damien Demozay, Valentina Manfè, Richard D DiMarchi

RSC Chem Biol· July 2024

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GLP-1-directed NMDA receptor antagonism for obesity treatment.
Jonas Petersen, Mette Q Ludwig, Vaida Juozaityte, Pablo Ranea-Robles, Charlotte Svendsen, Richard D DiMarchi

Nature· May 2024

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Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice.
Arkadiusz Liskiewicz, Ahmed Khalil, Daniela Liskiewicz, Aaron Novikoff, Gerald Grandl, Richard D DiMarchi

Nat Metab· December 2023

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GIPR/GLP-1R dual agonist therapies for diabetes and weight loss-chemistry, physiology, and clinical applications.
Jonathan E Campbell, Timo D Müller, Brian Finan, Richard D DiMarchi, Matthias H Tschöp

Cell Metab· September 2023

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GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease.
Stephan Sachs, Anna Götz, Brian Finan, Annette Feuchtinger, Richard D DiMarchi

Cardiovasc Diabetol· August 2023

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Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome.
Gandhari Maity-Kumar, Lisa Ständer, Meri DeAngelis, Sooyeon Lee, Anna Molenaar, Richard D DiMarchi

Mol Metab· December 2022

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Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist.
Francois Moreau, Nicholas S Kirk, Fa Zhang, Vasily Gelfanov, Edward O List, Richard D DiMarchi

Nat Commun· November 2022

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Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice.
Patrick J Knerr, Stephanie A Mowery, Jonathan D Douros, Bhavesh Premdjee, Karina Rahr Hjøllund, Richard D DiMarchi

Mol Metab· September 2022

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GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice.
Carmelo Quarta, Kerstin Stemmer, Aaron Novikoff, Bin Yang, Felix Klingelhuber, Richard D DiMarchi

Nat Metab· August 2022

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Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis.
Andy Weiss, Caitlin C Murdoch, Katherine A Edmonds, Matthew R Jordan, Andrew J Monteith, Richard D DiMarchi

Cell· June 2022

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Peptide Model of the Mutant Proinsulin Syndrome. II. Nascent Structure and Biological Implications.
Yanwu Yang, Michael D Glidden, Balamurugan Dhayalan, Alexander N Zaykov, Yen-Shan Chen, Richard D DiMarchi

Front Endocrinol (Lausanne)· April 2022

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Recent Advances in Incretin-Based Pharmacotherapies for the Treatment of Obesity and Diabetes.
Qiming Tan, Seun E Akindehin, Camila E Orsso, Richelle C Waldner, Richard D DiMarchi

Front Endocrinol (Lausanne)· April 2022

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Peptide Model of the Mutant Proinsulin Syndrome. I. Design and Clinical Correlation.
Balamurugan Dhayalan, Michael D Glidden, Alexander N Zaykov, Yen-Shan Chen, Yanwu Yang, Richard D DiMarchi

Front Endocrinol (Lausanne)· April 2022

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Efficacy of glucagon-like peptide-1 and estrogen dual agonist in pancreatic islets protection and pre-clinical models of insulin-deficient diabetes.
Taylor Fuselier, Paula Mota de Sa, M M Fahd Qadir, Beibei Xu, Camille Allard, Richard D Dimarchi

Cell Rep Med· April 2022

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Anti-obesity drug discovery: advances and challenges.
Timo D Müller, Matthias Blüher, Matthias H Tschöp, Richard D DiMarchi

Nat Rev Drug Discov· March 2022

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A Facile Procedure for One-Pot Stable Conjugation of Two Proglucagon Cysteine-Containing Peptide Analogs.
Rongjun He, Stephanie A Mowery, Joseph Chabenne, Brian Finan, John P Mayer, Richard D DiMarchi

Front Endocrinol (Lausanne)· February 2022

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A viral insulin-like peptide is a natural competitive antagonist of the human IGF-1 receptor.
Fa Zhang, Emrah Altindis, C Ronald Kahn, Richard D DiMarchi, Vasily Gelfanov

Mol Metab· November 2021

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Icodec Advances the Prospect of Once-Weekly Insulin Injection.
Richard D DiMarchi, John P Mayer

J Med Chem· July 2021

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