Publications by authors named "Richard Rampulla"

Claim this Profile
D
Discovery of Potent and Selective Quinoxaline-Based Protease-Activated Receptor 4 (PAR4) Antagonists for the Prevention of Arterial Thrombosis.
Xiaojun Zhang, Wen Jiang, Jeremy M Richter, J Alex Bates, Samuel K Reznik, Richard Rampulla

J Med Chem· March 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
O
Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities.
Elizabeth A Jurica, Ximao Wu, Kristin N Williams, Lauren E Haque, Richard A Rampulla

Bioorg Med Chem· May 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation.
Alicia Regueiro-Ren, Sing-Yuen Sit, Yan Chen, Jie Chen, Jacob J Swidorski, Richard Rampulla

J Med Chem· September 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1-pyrazol-1-yl)methyl)phosphonate (BMS-820132).
Yan Shi, Ying Wang, Wei Meng, Robert P Brigance, Denis E Ryono, Richard Rampulla

J Med Chem· March 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design.
Ashvinikumar V Gavai, Derek Norris, George Delucca, David Tortolani, John S Tokarski, Richard Rampulla

J Med Chem· October 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Conformational-Analysis-Guided Discovery of 2,3-Disubstituted Pyridine IDO1 Inhibitors.
Emily C Cherney, Liping Zhang, Weiwei Guo, Audris Huang, David Williams, Richard Rampulla

ACS Med Chem Lett· July 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Solvent-specific, DAST-mediated intramolecular Friedel-Crafts reaction: access to dibenzoxepine-fused spirooxindoles.
Ramesh Samikannu, Sankaranarayanan Sethuraman, Nagaraja Akula, Vignesh Radhakrishnan, Srinivasarao Kamisetti, Richard Rampulla

Org Biomol Chem· March 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection.
Li-Qiang Sun, Eric Mull, Stanley D'Andrea, Barbara Zheng, Sheldon Hiebert, Richard Rampulla

J Med Chem· December 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design, Synthesis, and Structure-Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody-Drug Conjugates.
Naidu S Chowdari, Yong Zhang, Ivar McDonald, Walter Johnson, David R Langley, Richard Rampulla

J Med Chem· November 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Chemical Modification of Linkers Provides Stable Linker-Payloads for the Generation of Antibody-Drug Conjugates.
Yam B Poudel, Naidu S Chowdari, Heng Cheng, Christiana I Iwuagwu, H Dalton King, Richard Rampulla

ACS Med Chem Lett· November 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK.
Anurag S Srivastava, Soo Ko, Scott H Watterson, Mark A Pattoli, Stacey Skala, Richard Rampulla

ACS Med Chem Lett· November 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis of Differentially Protected Azatryptophan Analogs via Pd(dba)/XPhos Catalyzed Negishi Coupling of -Ts Azaindole Halides with Zinc Derivative from Fmoc-Protected -Butyl ()-2-Amino-3-iodopropanoate.
Roshan Y Nimje, Devaiah Vytla, Prakasam Kuppusamy, Rajeswari Velayuthaperumal, Lokesh Babu Jarugu, Richard A Rampulla

J Org Chem· September 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design, synthesis and SAR study of bridged tricyclic pyrimidinone carboxamides as HIV-1 integrase inhibitors.
Manoj Patel, B Narasimhulu Naidu, Ira Dicker, Helen Higley, Zeyu Lin, Richard Rampulla

Bioorg Med Chem· July 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species.
Wu Yang, Yufeng Wang, Amy Lai, Charles G Clark, James R Corte, Richard A Rampulla

J Med Chem· July 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
O
Optimization of Nicotinamides as Potent and Selective IRAK4 Inhibitors with Efficacy in a Murine Model of Psoriasis.
Satheesh Nair, Sreekantha Ratna Kumar, Venkatram Reddy Paidi, Ramesh Sistla, Durgarao Kantheti, Richard A Rampulla

ACS Med Chem Lett· July 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design, synthesis and biological evaluation of phenol-linked uncialamycin antibody-drug conjugates.
Yam B Poudel, Chetana Rao, Srikanth Kotapati, Madhura Deshpande, Lourdes Thevanayagam, Richard Rampulla

Bioorg Med Chem Lett· January 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups.
James R Corte, Donald J P Pinto, Tianan Fang, Honey Osuna, Wu Yang, Richard Rampulla

J Med Chem· January 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt-Identification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy.
David Marcoux, James J-W Duan, Qing Shi, Robert J Cherney, Anurag S Srivastava, Richard A Rampulla

J Med Chem· November 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor.
Heather J Finlay, Ji Jiang, Richard Rampulla, Mark E Salvati, Jennifer X Qiao

ACS Med Chem Lett· June 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK).
Scott H Watterson, Qingjie Liu, Myra Beaudoin Bertrand, Douglas G Batt, Ling Li, Richard Rampulla

J Med Chem· April 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Identification and Preclinical Pharmacology of ((1 R,3 S)-1-Amino-3-(( S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P) Modulator Advanced into Clinical Trials.
John L Gilmore, Hai-Yun Xiao, T G Murali Dhar, Michael G Yang, Zili Xiao, Richard Rampulla

J Med Chem· March 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists.
Jun Shi, Zhengxiang Gu, Elizabeth Anne Jurica, Ximao Wu, Lauren E Haque, Richard A Rampulla

J Med Chem· February 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor.
Barbara Zheng, Stanley V D'Andrea, Li-Qiang Sun, Alan Xiangdong Wang, Yan Chen, Richard A Rampulla

ACS Med Chem Lett· February 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders.
Qingjie Liu, Qing Shi, David Marcoux, Douglas G Batt, Lyndon Cornelius, Richard A Rampulla

J Med Chem· June 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Selective I Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide.
Prashantha Gunaga, John Lloyd, Somanadham Mummadi, Abhisek Banerjee, Naveen Kumar Dhondi, Richard Rampulla

J Med Chem· May 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis