Publications by authors named "Robert Lake"

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Auranofin Synergizes with Cisplatin in Reducing Tumor Burden of NOTCH-Dependent Ovarian Cancer.
Robert J Lake, Parisa Nikeghbal, Irina V Lagutina, Kimberly K Leslie, Mara P Steinkamp

Cancer Res Commun· October 2025

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Seeing clearly: A novel model for low vision screening and evaluation in hospitalized older adults.
Kelly Singleton, Aprile I Doubt, Sara A Restuccio, Alyson N Honko, Ilana S Stol, Robert S Lake

J Am Geriatr Soc· February 2025

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ATP-Dependent Chromatin Remodeler CSB Couples DNA Repair Pathways to Transcription with Implications for Cockayne Syndrome and Cancer Therapy.
Rabeya Bilkis, Robert J Lake, Hua-Ying Fan

Cells· February 2025

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The CSB chromatin remodeler regulates PARP1- and PARP2-mediated single-strand break repair at actively transcribed DNA regions.
Rabeya Bilkis, Robert J Lake, Karen L Cooper, Alan Tomkinson, Hua-Ying Fan

Nucleic Acids Res· August 2023

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Analyzing the Interaction of RBPJ with Mitotic Chromatin and Its Impact on Transcription Reactivation upon Mitotic Exit.
Kostiantyn Dreval, Robert J Lake, Hua-Ying Fan

Methods Mol Biol· June 2022

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Dynamic Interplay between Cockayne Syndrome Protein B and Poly(ADP-Ribose) Polymerase 1 during Oxidative DNA Damage Repair.
Robert J Lake, Rabeya Bilkis, Hua-Ying Fan

Biomedicines· February 2022

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A Novel Flow Cytometric Assay to Identify Inhibitors of RBPJ-DNA Interactions.
Robert J Lake, Mark K Haynes, Kostiantyn Dreval, Rabeya Bilkis, Larry A Sklar

SLAS Discov· September 2020

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HDAC1 negatively regulates selective mitotic chromatin binding of the Notch effector RBPJ in a KDM5A-dependent manner.
Kostiantyn Dreval, Robert J Lake, Hua-Ying Fan

Nucleic Acids Res· May 2019

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Poly(ADP-ribose) polymerase 1 (PARP1) promotes oxidative stress-induced association of Cockayne syndrome group B protein with chromatin.
Erica L Boetefuer, Robert J Lake, Kostiantyn Dreval, Hua-Ying Fan

J Biol Chem· November 2018

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Mechanistic insights into the regulation of transcription and transcription-coupled DNA repair by Cockayne syndrome protein B.
Erica L Boetefuer, Robert J Lake, Hua-Ying Fan

Nucleic Acids Res· September 2018

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NAP1L1 accelerates activation and decreases pausing to enhance nucleosome remodeling by CSB.
Ju Yeon Lee, Robert J Lake, Jaewon Kirk, Vilhelm A Bohr, Hua-Ying Fan

Nucleic Acids Res· May 2017

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The CSB chromatin remodeler and CTCF architectural protein cooperate in response to oxidative stress.
Robert J Lake, Erica L Boetefuer, Kyoung-Jae Won, Hua-Ying Fan

Nucleic Acids Res· March 2016

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Global analysis of physical and functional RNA targets of hnRNP L reveals distinct sequence and epigenetic features of repressed and enhanced exons.
Brian S Cole, Iulia Tapescu, Samuel J Allon, Michael J Mallory, Jinsong Qiu, Robert J Lake

RNA· December 2015

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Standing at the crossroads in HIV management: implications for primary care practice from the AIDS 2014 conference.
Levinia Crooks, Michael R Kidd, Robert Lake, Edwina J Wright, Edward Reis

Med J Aust· October 2014

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The sequence-specific transcription factor c-Jun targets Cockayne syndrome protein B to regulate transcription and chromatin structure.
Robert J Lake, Erica L Boetefuer, Pei-Fang Tsai, Jieun Jeong, Inchan Choi

PLoS Genet· April 2014

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RBPJ, the major transcriptional effector of Notch signaling, remains associated with chromatin throughout mitosis, suggesting a role in mitotic bookmarking.
Robert J Lake, Pei-Fang Tsai, Inchan Choi, Kyoung-Jae Won, Hua-Ying Fan

PLoS Genet· March 2014

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Structure, function and regulation of CSB: a multi-talented gymnast.
Robert J Lake, Hua-Ying Fan

Mech Ageing Dev· December 2013

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ATP-dependent chromatin remodeling by Cockayne syndrome protein B and NAP1-like histone chaperones is required for efficient transcription-coupled DNA repair.
Iltaeg Cho, Pei-Fang Tsai, Robert J Lake, Asjad Basheer, Hua-Ying Fan

PLoS Genet· April 2013

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Reciprocally regulated chromatin association of Cockayne syndrome protein B and p53 protein.
Robert J Lake, Asjad Basheer, Hua-Ying Fan

J Biol Chem· October 2011

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Public engagement on ethical principles in allocating scarce resources during an influenza pandemic.
Tracey M Bailey, Christina Haines, Rhonda J Rosychuk, Thomas J Marrie, Olive Yonge, Robert Lake

Vaccine· April 2011

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Trp53 regulates Notch 4 signaling through Mdm2.
Youping Sun, Malgorzata Klauzinska, Robert J Lake, Joseph M Lee, Stefania Santopietro

J Cell Sci· April 2011

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Modifiers of notch transcriptional activity identified by genome-wide RNAi.
Philippos Mourikis, Robert J Lake, Christopher B Firnhaber, Brian S DeDecker

BMC Dev Biol· October 2010

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RETRACTED: Molecular structure and dimeric organization of the Notch extracellular domain as revealed by electron microscopy.
Deborah F Kelly, Robert J Lake, Teije C Middelkoop, Hua-Ying Fan, Spyros Artavanis-Tsakonas

PLoS One· May 2010

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UV-induced association of the CSB remodeling protein with chromatin requires ATP-dependent relief of N-terminal autorepression.
Robert J Lake, Anastasia Geyko, Girish Hemashettar, Yu Zhao, Hua-Ying Fan

Mol Cell· January 2010

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Information sharing: Breaking down the boundaries.
Robert Lake

Health Serv J· October 2009

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