Publications by authors named "Robert Macci"

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Azepino-indazoles as calcitonin gene-related peptide (CGRP) receptor antagonists.
Stephen E Mercer, Prasad V Chaturvedula, Charles M Conway, Deborah A Cook, Carl D Davis, Robert Macci

Bioorg Med Chem Lett· January 2021

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Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): a potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery.
Prasad V Chaturvedula, Stephen E Mercer, Sokhom S Pin, George Thalody, Cen Xu, Robert Macci

Bioorg Med Chem Lett· June 2013

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The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 2.
Xiaojun Han, Rita L Civiello, Charles M Conway, Deborah A Cook, Carl D Davis, Robert Macci

Bioorg Med Chem Lett· March 2013

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The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 1.
Xiaojun Han, Rita L Civiello, Charles M Conway, Deborah A Cook, Carl D Davis, Robert Macci

Bioorg Med Chem Lett· July 2012

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Carbamates as potent calcitonin gene-related peptide antagonists with improved solution stability.
Andrew P Degnan, Charles M Conway, Richard A Dalterio, Robert Macci, Stephen E Mercer

Bioorg Med Chem Lett· July 2009

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Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): a potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure.
Andrew P Degnan, Prasad V Chaturvedula, Charles M Conway, Deborah A Cook, Carl D Davis, Robert Macci

J Med Chem· August 2008

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An orally active corticotropin releasing factor 1 receptor antagonist from 8-aryl-1,3a,7,8-tetraaza-cyclopenta[a]indenes.
Xiaojun Han, Rita Civiello, Sokhom S Pin, Kevin Burris, Lynn A Balanda, Robert Macci

Bioorg Med Chem Lett· April 2007

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