Publications by authors named "Robert Pacifici"

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Orthosteric inhibition of MutSβ ATPase function: First disclosure of MSH3-bound small molecule inhibitors.
Gareth N Brace, Karsten Tillack, Peter D Johnson, Markus Ritzefeld, Sabine Schaertl, Robert E Pacifici

Bioorg Med Chem Lett· December 2025

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Lack of Evidence for Kynurenine Pathway Dysfunction in Huntington's Disease: CSF and Plasma Analyses from the HDClarity Study.
Vinod Khetarpal, Todd Herbst, Celia Dominguez, Ignacio Munoz-Sanjuan, Cristina Sampaio, Robert Pacifici

J Huntingtons Dis· February 2025

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NRF2 activation by reversible KEAP1 binding induces the antioxidant response in primary neurons and astrocytes of a Huntington's disease mouse model.
Daniele Moretti, Sara Tambone, Mauro Cerretani, Paola Fezzardi, Antonino Missineo, Robert Pacifici

Free Radic Biol Med· January 2021

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Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction.
Jesus M Ontoria, Ilaria Biancofiore, Paola Fezzardi, Federica Ferrigno, Esther Torrente, Robert Pacifici

ACS Med Chem Lett· May 2020

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Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery.
Nathan P Coussens, G Sitta Sittampalam, Rajarshi Guha, Kyle Brimacombe, Abigail Grossman, Robert Pacifici

Clin Transl Sci· September 2018

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Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1).
Alberto Bresciani, Antonino Missineo, Mariana Gallo, Mauro Cerretani, Paola Fezzardi, Robert Pacifici

Arch Biochem Biophys· October 2017

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Polyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopy.
Valentina Fodale, Natalie C Kegulian, Margherita Verani, Cristina Cariulo, Lucia Azzollini, Robert Pacifici

PLoS One· August 2015

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Pharmacokinetics of memantine in rats and mice.
Maria G Beconi, David Howland, Larry Park, Kathryn Lyons, Joseph Giuliano, Robert Pacifici

PLoS Curr· December 2011

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A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors.
Sabine Schaertl, Michael Prime, John Wityak, Celia Dominguez, Ignacio Munoz-Sanjuan, Robert E Pacifici

J Biomol Screen· June 2010

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