Publications by authors named "Robert Thorne"

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Activation parameters, enthalpy-entropy compensation and the temperature-dependent activity of enzymes.
Matthew J McLeod, Robert E Thorne

bioRxiv· November 2025

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Dual targeting of transferrin receptor and CD98hc enhances brain exposure of large molecules.
Robert C Wells, Padma Akkapeddi, Darren Chan, David Joy, Arash Moshkforoush, Robert G Thorne

Cell Rep· August 2025

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Transferrin receptor-targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA.
Michelle E Pizzo, Edward D Plowey, Nathalie Khoury, Wanda Kwan, Jordan Abettan, Robert G Thorne

Science· August 2025

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A review of diffuse hemispheric glioma, H3 G34-mutant disease development, DNA repair, microenvironment, and treatments on the horizon.
Cameron Crowell, Ziwen Zhu, Yingxiang Li, Maria L Varela, Quinn Ostrom, Robert Thorne

NPJ Precis Oncol· August 2025

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Transferrin receptor-mediated transport at the blood-brain barrier is elevated during early development and maintained across aging and in an Alzheimer's mouse model.
Vanessa O Torres, Michelle E Pizzo, Darren Chan, Jason C Dugas, David Huynh, Robert G Thorne

J Cereb Blood Flow Metab· August 2025

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A structural perspective on the temperature dependent activity of enzymes.
Matthew J McLeod, Sarah A E Barwell, Todd Holyoak, Robert E Thorne

Structure· May 2025

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Instrumentation and methods for efficient time-resolved X-ray crystallography of biomolecular systems with sub-10 ms time resolution.
John A Indergaard, Kashfia Mahmood, Leo Gabriel, Gary Zhong, Adam Lastovka, Robert E Thorne

IUCrJ· May 2025

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Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution.
Nathalie Khoury, Michelle E Pizzo, Claire B Discenza, David Joy, David Tatarakis, Robert G Thorne

Nat Commun· February 2025

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Ice formation and its elimination in cryopreservation of oocytes.
Abdallah W Abdelhady, David W Mittan-Moreau, Patrick L Crane, Matthew J McLeod, Soon Hon Cheong, Robert E Thorne

Sci Rep· August 2024

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Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier.
Scarlett J Barker, Mai B Thayer, Chaeyoung Kim, David Tatarakis, Matthew J Simon, Robert G Thorne

Sci Transl Med· August 2024

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A structural perspective on the temperature-dependent activity of enzymes.
Matthew J McLeod, Sarah A E Barwell, Todd Holyoak, Robert Edward Thorne

bioRxiv· August 2024

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Ice formation and its elimination in cryopreservation of oocytes.
Abdallah W Abdelhady, David W Mittan-Moreau, Patrick L Crane, Matthew J McLeod, Soon Hon Cheong, Robert E Thorne

Res Sq· May 2024

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Blood-brain borders: a proposal to address limitations of historical blood-brain barrier terminology.
Jerome Badaut, Jean-François Ghersi-Egea, Robert G Thorne, Jan Pieter Konsman

Fluids Barriers CNS· January 2024

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Ice formation and its elimination in cryopreservation of bovine oocytes.
Abdallah W Abdelhady, David W Mittan-Moreau, Patrick L Crane, Matthew J McLeod, Soon Hon Cheong, Robert E Thorne

bioRxiv· November 2023

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Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes.
Xiang Wang, Vitaliy V Bondar, Oliver B Davis, Michael T Maloney, Maayan Agam, Robert G Thorne

Elife· October 2023

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Author Correction: CD98hc is a target for brain delivery of biotherapeutics.
Kylie S Chew, Robert C Wells, Arash Moshkforoush, Darren Chan, Kendra J Lechtenberg, Robert G Thorne

Nat Commun· September 2023

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CD98hc is a target for brain delivery of biotherapeutics.
Kylie S Chew, Robert C Wells, Arash Moshkforoush, Darren Chan, Kendra J Lechtenberg, Robert G Thorne

Nat Commun· August 2023

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Identifying structural and dynamic changes during the Biliverdin Reductase B catalytic cycle.
Eunjeong Lee, Matthew J McLeod, Jasmina S Redzic, Barbara Marcolin, Robert E Thorne

Front Mol Biosci· August 2023

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A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models.
Bettina van Lengerich, Lihong Zhan, Dan Xia, Darren Chan, David Joy, Robert G Thorne

Nat Neurosci· March 2023

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Mesoproterozoic surface oxygenation accompanied major sedimentary manganese deposition at 1.4 and 1.1 Ga.
Sam C Spinks, Erik A Sperling, Robert L Thorne, Felicity LaFountain, Alistair J R White

Geobiology· January 2023

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Determining biomolecular structures near room temperature using X-ray crystallography: concepts, methods and future optimization.
Robert E Thorne

Acta Crystallogr D Struct Biol· January 2023

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Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.
Dan Xia, Steve Lianoglou, Thomas Sandmann, Meredith Calvert, Jung H Suh, Robert G Thorne

Mol Neurodegener· June 2022

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Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme.
Annie Arguello, Cathal S Mahon, Meredith E K Calvert, Darren Chan, Jason C Dugas, Robert G Thorne

J Exp Med· March 2022

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Megawatt pulses from an all-fiber and self-starting femtosecond oscillator.
Henry Haig, Pavel Sidorenko, Robert Thorne, Frank Wise

Opt Lett· February 2022

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High-resolution single-particle cryo-EM of samples vitrified in boiling nitro-gen.
Tyler Engstrom, Jonathan A Clinger, Katherine A Spoth, Oliver B Clarke, David S Closs, Robert E Thorne

IUCrJ· November 2021

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