Publications by authors named "Todd Holyoak"

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Streptococcus pneumoniae HtrA is a dynamic and monomeric virulence factor capable of forming larger oligomeric complexes.
Eunjeong Lee, Jasmina S Redzic, Blaine Gordon, Anthony J Saviola, Norman Tran, Todd Holyoak

Protein Sci· January 2026

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Structural mechanisms for cold-adapted activity of phosphoenolpyruvate carboxykinase.
Matthew J McLeod, Shauhin Yazdani, Sarah A E Barwell, Todd Holyoak

Protein Sci· November 2025

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Structure of the immunoglobulin A protease reveals a modular and minimizable architecture distinct from other immunoglobulin A proteases.
Norman Tran, Aaron Frenette, Todd Holyoak

Proc Natl Acad Sci U S A· September 2025

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A structural perspective on the temperature dependent activity of enzymes.
Matthew J McLeod, Sarah A E Barwell, Todd Holyoak, Robert E Thorne

Structure· May 2025

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The neglected PCK1/glucagon (inter)action in nutrient homeostasis beyond gluconeogenesis: Disease pathogenesis and treatment.
Romina Bertinat, Todd Holyoak, Rodrigo Gatica, Nery Jara, Iván González-Chavarría

Mol Metab· April 2025

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The structure of the Gemella haemolysans M26 IgA1 protease trypsin-like domain.
Norman Tran, Jasmina S Redzic, Elan Z Eisenmesser, Todd Holyoak

Acta Crystallogr F Struct Biol Commun· April 2025

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Identifying and controlling inactive and active conformations of a serine protease.
Eunjeong Lee, Norman Tran, Jasmina S Redzic, Harmanpreet Singh, Lorena Alamillo, Todd Holyoak

Sci Adv· April 2025

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A structural perspective on the temperature-dependent activity of enzymes.
Matthew J McLeod, Sarah A E Barwell, Todd Holyoak, Robert Edward Thorne

bioRxiv· August 2024

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Biochemical, structural, and kinetic characterization of PP -dependent phosphoenolpyruvate carboxykinase from Propionibacterium freudenreichii.
Matthew J McLeod, Todd Holyoak

Proteins· September 2023

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The H163A mutation unravels an oxidized conformation of the SARS-CoV-2 main protease.
Norman Tran, Sathish Dasari, Sarah A E Barwell, Matthew J McLeod, Subha Kalyaanamoorthy, Todd Holyoak

Nat Commun· September 2023

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A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5'-triphosphate.
Matthew J McLeod, Norman Tran, Gregory D McCluskey, Tom D Gillis, Stephen L Bearne, Todd Holyoak

Protein Sci· June 2023

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PYK-SubstitutionOME: an integrated database containing allosteric coupling, ligand affinity and mutational, structural, pathological, bioinformatic and computational information about pyruvate kinase isozymes.
Liskin Swint-Kruse, Larissa L Dougherty, Braelyn Page, Tiffany Wu, Pierce T O'Neil, Todd Holyoak

Database (Oxford)· May 2023

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Directional regulation of cytosolic PEPCK catalysis is mediated by competitive binding of anions.
Sarah A E Barwell, Ramona Duman, Armin Wagner, Todd Holyoak

Biochem Biophys Res Commun· December 2022

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A substrate-induced gating mechanism is conserved among Gram-positive IgA1 metalloproteases.
Jasmina S Redzic, Jeremy Rahkola, Norman Tran, Todd Holyoak, Eunjeong Lee

Commun Biol· November 2022

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Millisecond mix-and-quench crystallography (MMQX) enables time-resolved studies of PEPCK with remote data collection.
Jonathan A Clinger, David W Moreau, Matthew J McLeod, Todd Holyoak, Robert E Thorne

IUCrJ· September 2021

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Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease.
Zhiming Wang, Jeremy Rahkola, Jasmina S Redzic, Ying-Chih Chi, Norman Tran, Todd Holyoak

Nat Commun· November 2020

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Cytosolic phosphoenolpyruvate carboxykinase is expressed in α-cells from human and murine pancreas.
Francisco Westermeier, Todd Holyoak, Rodrigo Gatica, Fernando Martínez, Marianne Negrón

J Cell Physiol· January 2020

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Characterization of 3-[(Carboxymethyl)thio]picolinic Acid: A Novel Inhibitor of Phosphoenolpyruvate Carboxykinase.
Matthew J Mcleod, Anthony P Krismanich, Abdeljalil Assoud, Gary I Dmitrienko, Todd Holyoak

Biochemistry· September 2019

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Gluconeogenic Enzymes in β-Cells: Pharmacological Targets for Improving Insulin Secretion.
Francisco Westermeier, Todd Holyoak, Joel L Asenjo, Rodrigo Gatica, Francisco Nualart

Trends Endocrinol Metab· August 2019

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Exploring the limits of the usefulness of mutagenesis in studies of allosteric mechanisms.
Qingling Tang, Aileen Y Alontaga, Todd Holyoak, Aron W Fenton

Hum Mutat· September 2017

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Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella.
Ulrich Eckhard, Hina Bandukwala, Michael J Mansfield, Giada Marino, Jiujun Cheng, Todd Holyoak

Nat Commun· September 2017

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Asymmetric Anchoring Is Required for Efficient Ω-Loop Opening and Closing in Cytosolic Phosphoenolpyruvate Carboxykinase.
Danica S Cui, Aron Broom, Matthew J Mcleod, Elizabeth M Meiering, Todd Holyoak

Biochemistry· April 2017

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Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase.
Troy A Johnson, Matthew J Mcleod, Todd Holyoak

Biochemistry· January 2016

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Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate Carboxykinase by 3-Mercaptopicolinic Acid.
Marc D Balan, Matthew J Mcleod, William R Lotosky, Mark Ghaly, Todd Holyoak

Biochemistry· September 2015

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Three rare diseases in one Sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith-Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity.
David R Adams, Hongjie Yuan, Todd Holyoak, Katrina H Arajs, Parvin Hakimi

Mol Genet Metab· November 2014

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