Publications by authors named "Roberta Bortolozzi"

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Microwave-Enhanced Synthesis of 2-Styrylquinoline-4-Carboxamides With Promising Anti-Lymphoma Activity.
Ignazio Sardo, Lorenzo Manfreda, Giulia Maria Titone, Marilia Barreca, Roberta Bivacqua, Roberta Bortolozzi

Arch Pharm (Weinheim)· November 2025

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Design and Synthesis of 2-substituted [1,2,4]Triazolo[1,5-a]pyrimidines Tethered with Umbelliferone as Selective Carbonic Anhydrase IX and XII Inhibitors.
Romeo Romagnoli, Elena Romagnoli, Andrea Brancale, Claudiu T Supuran, Alessio Nocentini, Roberta Bortolozzi

Anticancer Agents Med Chem· October 2025

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A first-in-class Wiskott-Aldrich syndrome protein activator with antitumor activity in hematologic cancers.
Filippo Spriano, Giulio Sartori, Jacopo Sgrignani, Laura Barnabei, Alberto J Arribas, Roberta Bortolozzi

Haematologica· November 2024

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A Multi-Omics Approach Reveals Enrichment in Metabolites Involved in the Regulation of the Glutathione Pathway in LIN28B-Dependent Cancer Cells.
Matteo Stocchero, Diana Corallo, Silvia Bresolin, Marcella Pantile, Paola Pirillo, Roberta Bortolozzi

Int J Mol Sci· January 2024

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Design, synthesis, and biological investigation of selective human carbonic anhydrase II, IX, and XII inhibitors using 7-aryl/heteroaryl triazolopyrimidines bearing a sulfanilamide scaffold.
Romeo Romagnoli, Tiziano De Ventura, Stefano Manfredini, Erika Baldini, Claudiu T Supuran, Roberta Bortolozzi

J Enzyme Inhib Med Chem· December 2023

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Molecular and functional profiling of chemotolerant cells unveils nucleoside metabolism-dependent vulnerabilities in medulloblastoma.
Elena Mariotto, Elena Rampazzo, Roberta Bortolozzi, Fatlum Rruga, Ilaria Zeni

Acta Neuropathol Commun· November 2023

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Surviving the hunger games: Metabolic reprogramming in medulloblastoma.
Lorenzo Manfreda, Elena Rampazzo, Luca Persano, Giampietro Viola, Roberta Bortolozzi

Biochem Pharmacol· September 2023

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Identification of pyrrolo[3',4':3,4]cyclohepta[1,2-d][1,2]oxazoles as promising new candidates for the treatment of lymphomas.
Marilia Barreca, Virginia Spanò, Roberta Rocca, Roberta Bivacqua, Gianmarco Gualtieri, Roberta Bortolozzi

Eur J Med Chem· June 2023

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Identification of Homoharringtonine as a potent inhibitor of glioblastoma cell proliferation and migration.
Elena Porcù, Francesca Maule, Lorenzo Manfreda, Elena Mariotto, Silvia Bresolin, Roberta Bortolozzi

Transl Res· January 2023

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Design, Synthesis and Biological Investigation of 2-Anilino Triazolopyrimidines as Tubulin Polymerization Inhibitors with Anticancer Activities.
Romeo Romagnoli, Paola Oliva, Filippo Prencipe, Stefano Manfredini, Federica Budassi, Roberta Bortolozzi

Pharmaceuticals (Basel)· August 2022

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Synthesis and Biological Evaluation of Highly Active 7-Anilino Triazolopyrimidines as Potent Antimicrotubule Agents.
Paola Oliva, Romeo Romagnoli, Barbara Cacciari, Stefano Manfredini, Chiara Padroni, Roberta Bortolozzi

Pharmaceutics· June 2022

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Synthesis of 2H-Imidazo[2',1':2,3] [1,3]thiazolo[4,5-e]isoindol-8-yl-phenylureas with promising therapeutic features for the treatment of acute myeloid leukemia (AML) with FLT3/ITD mutations.
Vincenzo Cilibrasi, Virginia Spanò, Roberta Bortolozzi, Marilia Barreca, Maria Valeria Raimondi

Eur J Med Chem· May 2022

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Histone Deacetylase Inhibitors Impair Glioblastoma Cell Motility and Proliferation.
Elena Rampazzo, Lorenzo Manfreda, Silvia Bresolin, Alice Cani, Elena Mariotto, Roberta Bortolozzi

Cancers (Basel)· April 2022

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Cinnamic acid derivatives linked to arylpiperazines as novel potent inhibitors of tyrosinase activity and melanin synthesis.
Romeo Romagnoli, Paola Oliva, Filippo Prencipe, Stefano Manfredini, Maria Paola Germanò, Roberta Bortolozzi

Eur J Med Chem· March 2022

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Concise synthesis and biological evaluation of 2-Aryl-3-Anilinobenzo[b]thiophene derivatives as potent apoptosis-inducing agents.
Romeo Romagnoli, Delia Preti, Ernest Hamel, Roberta Bortolozzi, Giampietro Viola

Bioorg Chem· July 2021

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Developing novel classes of protein kinase CK1δ inhibitors by fusing [1,2,4]triazole with different bicyclic heteroaromatic systems.
Ilenia Grieco, Maicol Bissaro, Davide Benedetto Tiz, Daniel I Perez, Conception Perez, Roberta Bortolozzi

Eur J Med Chem· April 2021

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A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents.
Romeo Romagnoli, Paola Oliva, Maria Kimatrai Salvador, Stefano Manfredini, Chiara Padroni, Roberta Bortolozzi

Eur J Med Chem· March 2021

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Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors.
Virginia Spanò, Marilia Barreca, Roberta Rocca, Roberta Bortolozzi, Ruoli Bai

Eur J Med Chem· February 2021

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Synthesis, DNA-binding and antiproliferative properties of diarylquinolizinium derivatives.
Roberta Bortolozzi, Heiko Ihmels, Robin Schulte, Christopher Stremmel, Giampietro Viola

Org Biomol Chem· January 2021

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Pyrrolo[2',3':3,4]cyclohepta[1,2-][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types.
Virginia Spanò, Roberta Rocca, Marilia Barreca, Daniele Giallombardo, Alessandra Montalbano, Roberta Bortolozzi

J Med Chem· October 2020

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Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors.
Paola Oliva, Romeo Romagnoli, Stefano Manfredini, Andrea Brancale, Salvatore Ferla, Roberta Bortolozzi

Eur J Med Chem· August 2020

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Ecdysteroid Derivatives that Reverse P-Glycoprotein-Mediated Drug Resistance.
Roberta Bortolozzi, Andrea Luraghi, Elena Mattiuzzo, Alessandro Sacchetti, Alessandra Silvani

J Nat Prod· August 2020

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Design, synthesis and biological evaluation of 2-alkoxycarbonyl-3-anilinoindoles as a new class of potent inhibitors of tubulin polymerization.
Romeo Romagnoli, Filippo Prencipe, Paola Oliva, Maria Kimatrai Salvador, Andrea Brancale, Roberta Bortolozzi

Bioorg Chem· April 2020

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Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors.
Romeo Romagnoli, Paola Oliva, Maria Kimatrai Salvador, Maria Encarnacion Camacho, Chiara Padroni, Roberta Bortolozzi

Eur J Med Chem· November 2019

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Evaluating the effects of fluorine on biological properties and metabolic stability of some antitubulin 3-substituted 7-phenyl-pyrroloquinolinones.
Roberta Bortolozzi, Davide Carta, Matteo Dal Prà, Giuseppe Antoniazzi, Elena Mattiuzzo

Eur J Med Chem· September 2019

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