Publications by authors named "Rogier Smits"

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A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: comparison of hERG binding and target residence time with PF-3893787.
Mounir Andaloussi, Herman D Lim, Tiffany van der Meer, Maarten Sijm, Chris B M Poulie, Rogier A Smits

Bioorg Med Chem Lett· May 2013

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Effects of histamine H4 receptor ligands in a mouse model of gastric ulceration.
Maristella Adami, Cristina Pozzoli, Alessandro Menozzi, Simone Bertini, Benedetta Passeri, Rogier Smits

Pharmacology· September 2012

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Detailed structure-activity relationship of indolecarboxamides as H4 receptor ligands.
Harald Engelhardt, Iwan J P de Esch, Daniel Kuhn, Rogier A Smits, Obbe P Zuiderveld

Eur J Med Chem· August 2012

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Strain-dependent effects of the histamine H₄ receptor antagonist JNJ7777120 in a murine model of acute skin inflammation.
Gabriella Coruzzi, Cristina Pozzoli, Maristella Adami, Daniela Grandi, Nicoletta Guido, Rogier Smits

Exp Dermatol· January 2012

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Ligand based design of novel histamine H₄ receptor antagonists; fragment optimization and analysis of binding kinetics.
Rogier A Smits, Herman D Lim, Tiffany van der Meer, Sebastiaan Kuhne, Karin Bessembinder

Bioorg Med Chem Lett· January 2012

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Selective histamine H₃ and H₄ receptor agonists exert opposite effects against the gastric lesions induced by HCl in the rat stomach.
Gabriella Coruzzi, Maristella Adami, Cristina Pozzoli, Iwan J P de Esch, Rogier Smits

Eur J Pharmacol· November 2011

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Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H₄ and the ion channel serotonin 5-HT₃A.
Mark H P Verheij, Chris de Graaf, Gerdien E de Kloe, Saskia Nijmeijer, Henry F Vischer, Rogier A Smits

Bioorg Med Chem Lett· September 2011

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Triazole ligands reveal distinct molecular features that induce histamine H4 receptor affinity and subtly govern H4/H3 subtype selectivity.
Maikel Wijtmans, Chris de Graaf, Gerdien de Kloe, Enade P Istyastono, Judith Smit, Rogier A Smits

J Med Chem· March 2011

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Synthesis and QSAR of quinazoline sulfonamides as highly potent human histamine H4 receptor inverse agonists.
Rogier A Smits, Maristella Adami, Enade P Istyastono, Obbe P Zuiderveld, Cindy M E van Dam

J Med Chem· March 2010

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A new generation of anti-histamines: Histamine H4 receptor antagonists on their way to the clinic.
Harald Engelhardt, Rogier A Smits, Rob Leurs, Eric Haaksma, Iwan J P de Esch

Curr Opin Drug Discov Devel· September 2009

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Major advances in the development of histamine H4 receptor ligands.
Rogier A Smits, Rob Leurs, Iwan J P de Esch

Drug Discov Today· August 2009

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Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR studies.
Herman D Lim, Enade P Istyastono, Andrea van de Stolpe, Giuseppe Romeo, Silvia Gobbi, Rogier A Smits

Bioorg Med Chem· June 2009

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Pharmacological characterization of the new histamine H4 receptor agonist VUF 8430.
Herman D Lim, Maristella Adami, Elena Guaita, Thomas Werfel, Rogier A Smits

Br J Pharmacol· May 2009

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Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach.
Rogier A Smits, Iwan J P de Esch, Obbe P Zuiderveld, Joachim Broeker, Kamonchanok Sansuk

J Med Chem· December 2008

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Delineation of agonist binding to the human histamine H4 receptor using mutational analysis, homology modeling, and ab initio calculations.
Aldo Jongejan, Herman D Lim, Rogier A Smits, Iwan J P de Esch, Eric Haaksma

J Chem Inf Model· July 2008

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Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo.
Rogier A Smits, Herman D Lim, Agnes Hanzer, Obbe P Zuiderveld, Elena Guaita

J Med Chem· April 2008

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Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist.
Herman D Lim, Rogier A Smits, Remko A Bakker, Cindy M E van Dam, Iwan J P de Esch

J Med Chem· November 2006

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The emerging role of the histamine H4 receptor in anti-inflammatory therapy.
Herman D Lim, Rogier A Smits, Rob Leurs, Iwan J P De Esch

Curr Top Med Chem· October 2006

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Characterization of the histamine H4 receptor binding site. Part 1. Synthesis and pharmacological evaluation of dibenzodiazepine derivatives.
Rogier A Smits, Herman D Lim, Bart Stegink, Remko A Bakker, Iwan J P de Esch

J Med Chem· July 2006

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