Publications by authors named "Roni Chau"

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Dual targeting of transferrin receptor and CD98hc enhances brain exposure of large molecules.
Robert C Wells, Padma Akkapeddi, Darren Chan, David Joy, Arash Moshkforoush, Roni Chau

Cell Rep· August 2025

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Transferrin receptor-targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA.
Michelle E Pizzo, Edward D Plowey, Nathalie Khoury, Wanda Kwan, Jordan Abettan, Roni Chau

Science· August 2025

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Transferrin receptor-mediated transport at the blood-brain barrier is elevated during early development and maintained across aging and in an Alzheimer's mouse model.
Vanessa O Torres, Michelle E Pizzo, Darren Chan, Jason C Dugas, David Huynh, Roni Chau

J Cereb Blood Flow Metab· August 2025

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Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution.
Nathalie Khoury, Michelle E Pizzo, Claire B Discenza, David Joy, David Tatarakis, Roni Chau

Nat Commun· February 2025

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DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response.
Ernie Yulyaningsih, Jung H Suh, Melania Fanok, Roni Chau, Hilda Solanoy

Elife· September 2024

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Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Todd Logan, Matthew J Simon, Anil Rana, Gerald M Cherf, Ankita Srivastava, Roni Chau

Cell· March 2024

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Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis.
Robert A Craig, Brian M Fox, Cheng Hu, Katrina W Lexa, Maksim Osipov, Roni Chau

J Med Chem· December 2022

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Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.
Dan Xia, Steve Lianoglou, Thomas Sandmann, Meredith Calvert, Jung H Suh, Roni Chau

Mol Neurodegener· June 2022

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Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme.
Annie Arguello, Cathal S Mahon, Meredith E K Calvert, Darren Chan, Jason C Dugas, Roni Chau

J Exp Med· March 2022

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Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Todd Logan, Matthew J Simon, Anil Rana, Gerald M Cherf, Ankita Srivastava, Roni Chau

Cell· September 2021

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