Publications by authors named "Roque Bort"

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A robust reprogramming strategy for generating hepatocyte-like cells usable in pharmaco-toxicological studies.
Guillem Garcia-Llorens, Teresa Martínez-Sena, Eugenia Pareja, Laia Tolosa, José V Castell, Roque Bort

Stem Cell Res Ther· April 2023

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Modeling a Novel Variant of Glycogenosis IXa Using a Clonal Inducible Reprogramming System to Generate "Diseased" Hepatocytes for Accurate Diagnosis.
Guillem Garcia-Llorens, Sergi Lopez-Navarro, Teresa Jaijo, Jose V Castell, Roque Bort

J Pers Med· July 2022

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Derivation of healthy hepatocyte-like cells from a female patient with ornithine transcarbamylase deficiency through X-inactivation selection.
Ramon Santamaria, Maria Ballester, Guillem Garcia-Llorens, Francisco Martinez, Marina Blazquez, Roque Bort

Sci Rep· February 2022

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Direct conversion of human fibroblast to hepatocytes using a single inducible polycistronic vector.
Maria Ballester, Miguel Bolonio, Ramon Santamaria, José V Castell, Carmen Ribes-Koninckx, Roque Bort

Stem Cell Res Ther· November 2019

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Glutamine/glutamate metabolism rewiring in reprogrammed human hepatocyte-like cells.
Maria Ballester, Enrique Sentandreu, Giovanna Luongo, Ramon Santamaria, Miguel Bolonio, Roque Bort

Sci Rep· November 2019

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Dysfunctional mitochondrial fission impairs cell reprogramming.
Javier Prieto, Marian León, Xavier Ponsoda, Francisco García-García, Roque Bort

Cell Cycle· December 2016

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Silencing of hepatic fate-conversion factors induce tumorigenesis in reprogrammed hepatic progenitor-like cells.
Felipe Serrano, Maria García-Bravo, Marina Blazquez, Josema Torres, Jose V Castell, Roque Bort

Stem Cell Res Ther· July 2016

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Transfection of Primary Hepatocytes with Liver-Enriched Transcription Factors Using Adenoviral Vectors.
Marta Benet, Ramiro Jover, Roque Bort

Methods Mol Biol· May 2016

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Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming.
Javier Prieto, Marian León, Xavier Ponsoda, Ramón Sendra, Roque Bort

Nat Commun· March 2016

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Testing chemical carcinogenicity by using a transcriptomics HepaRG-based model?
T Y Doktorova, Reha Yildirimman, Liesbeth Ceelen, Mireia Vilardell, Tamara Vanhaecke, Roque Bort

EXCLI J· September 2015

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Maturation of induced pluripotent stem cell derived hepatocytes by 3D-culture.
Richard L Gieseck, Nicholas R F Hannan, Roque Bort, Neil A Hanley, Rosemary A L Drake

PLoS One· November 2014

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Transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models.
Tatyana Y Doktorova, Reha Yildirimman, Mathieu Vinken, Mireia Vilardell, Tamara Vanhaecke, Roque Bort

Carcinogenesis· June 2013

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A combination of transcriptomics and metabolomics uncovers enhanced bile acid biosynthesis in HepG2 cells expressing CCAAT/enhancer-binding protein β (C/EBPβ), hepatocyte nuclear factor 4α (HNF4α), and constitutive androstane receptor (CAR).
Marina Blazquez, Aitor Carretero, James K Ellis, Toby J Athersuch, Rachel Cavill, Roque Bort

J Proteome Res· June 2013

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Gata4 blocks somatic cell reprogramming by directly repressing Nanog.
Felipe Serrano, Carles F Calatayud, Marina Blazquez, Josema Torres, Jose V Castell, Roque Bort

Stem Cells· January 2013

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Interaction between Hhex and SOX13 modulates Wnt/TCF activity.
Vanessa Marfil, Marta Moya, Christophe E Pierreux, Jose V Castell, Frédéric P Lemaigre, Roque Bort

J Biol Chem· February 2010

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The carcinoGENOMICS project: critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays.
Mathieu Vinken, Tatyana Doktorova, Heidrun Ellinger-Ziegelbauer, Hans-Jürgen Ahr, Edward Lock, Roque Bort

Mutat Res· October 2008

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Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development.
Roque Bort, Massimo Signore, Kimberly Tremblay, Juan Pedro Martinez Barbera, Kenneth S Zaret

Dev Biol· February 2006

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miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1.
Jinhong Chang, Emmanuelle Nicolas, Debora Marks, Chris Sander, Anthony Lerro, Roque Bort

RNA Biol· July 2004

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Role of hepatocyte nuclear factor 3 gamma in the expression of human CYP2C genes.
Roque Bort, M José Gómez-Lechón, José V Castell, Ramiro Jover

Arch Biochem Biophys· June 2004

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Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas.
Roque Bort, Juan Pedro Martinez-Barbera, Rosa S P Beddington, Kenneth S Zaret

Development· February 2004

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Down-regulation of human CYP3A4 by the inflammatory signal interleukin-6: molecular mechanism and transcription factors involved.
Ramiro Jover, Roque Bort, M José Gómez-Lechón, José V Castell

FASEB J· November 2002

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Paths to the pancreas.
Roque Bort, Ken Zaret

Nat Genet· September 2002

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