Publications by authors named "Ruth Lehr"

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Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.
Carl A Machutta, Christopher S Kollmann, Kenneth E Lind, Xiaopeng Bai, Pan F Chan, Ruth Lehr

Nat Commun· July 2018

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Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.
Carl A Machutta, Christopher S Kollmann, Kenneth E Lind, Xiaopeng Bai, Pan F Chan, Ruth Lehr

Nat Commun· July 2017

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Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.
Philip A Harris, Scott B Berger, Jae U Jeong, Rakesh Nagilla, Deepak Bandyopadhyay, Ruth Lehr

J Med Chem· February 2017

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DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.
Philip A Harris, Bryan W King, Deepak Bandyopadhyay, Scott B Berger, Nino Campobasso, Ruth Lehr

J Med Chem· March 2016

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High throughput screening identifies ATP-competitive inhibitors of the NLRP1 inflammasome.
Philip A Harris, Chaya Duraiswami, Donald T Fisher, James Fornwald, Sandra J Hoffman, Ruth Lehr

Bioorg Med Chem Lett· July 2015

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Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT).
Hongfang Yang, Patricia F Medeiros, Kaushik Raha, Patricia Elkins, Kenneth E Lind, Ruth Lehr

ACS Med Chem Lett· May 2015

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Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis.
Philip A Harris, Deepak Bandyopadhyay, Scott B Berger, Nino Campobasso, Carol A Capriotti, Ruth Lehr

ACS Med Chem Lett· December 2013

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On the catalytic mechanism of human ATP citrate lyase.
Fan Fan, Howard J Williams, Joseph G Boyer, Taylor L Graham, Huizhen Zhao, Ruth Lehr

Biochemistry· June 2012

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Baculovirus production of fully-active phosphoinositide 3-kinase alpha as a p85alpha-p110alpha fusion for X-ray crystallographic analysis with ATP competitive enzyme inhibitors.
Robert H Sinnamon, Patrick McDevitt, Beth L Pietrak, Vaughan R Leydon, Yu Xue, Ruth Lehr

Protein Expr Purif· October 2010

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Kinetic mechanism and rate-limiting steps of focal adhesion kinase-1.
Jessica L Schneck, Jacques Briand, Stephanie Chen, Ruth Lehr, Patrick McDevitt

Biochemistry· August 2010

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Characterization of PI3K class IA isoforms with regulatory subunit p55alpha using a scintillation proximity assay.
Glenn S Van Aller, Jeff D Carson, Christine Fernandes, Ruth Lehr, Robert H Sinnamon

Anal Biochem· December 2008

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Effects of oncogenic p110alpha subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase.
Jeffrey D Carson, Glenn Van Aller, Ruth Lehr, Robert H Sinnamon, Robert B Kirkpatrick

Biochem J· January 2008

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Crystal structure of the kinase domain of serum and glucocorticoid-regulated kinase 1 in complex with AMP PNP.
Baoguang Zhao, Ruth Lehr, Angela M Smallwood, Thau F Ho, Kathleen Maley

Protein Sci· December 2007

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ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism.
Lusong Luo, Cynthia A Parrish, Neysa Nevins, Dean E McNulty, Amita M Chaudhari, Ruth Lehr

Nat Chem Biol· November 2007

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Selective binding and oligomerization of the murine granulocyte colony-stimulating factor receptor by a low molecular weight, nonpeptidyl ligand.
Michael L Doyle, Shin-Shay Tian, Stephen G Miller, Linda Kessler, Audrey E Baker, Ruth Lehr

J Biol Chem· March 2003

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Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production.
Sanjay Kumar, Charles R Hanning, Michael R Brigham-Burke, David J Rieman, Ruth Lehr

Cytokine· April 2002

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Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5).
James F Callahan, Joelle L Burgess, James A Fornwald, Laramie M Gaster, John D Harling, Ruth Lehr

J Med Chem· February 2002

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