Publications by authors named "Ruth Motter"

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Dual-Toxin ("Bivalent") Infant Botulism in California, 1976-2020: Epidemiologic, Clinical, and Laboratory Aspects.
Mayuri V Panditrao, Connie H Chung, Jessica M Khouri, Jason R Barash, Ruth N Motter

J Pediatr· February 2023

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Safety and immunogenicity of investigational recombinant botulinum vaccine, rBV A/B, in volunteers with pre-existing botulinum toxoid immunity.
Jessica M Khouri, Ruth N Motter, Stephen S Arnon

Vaccine· April 2018

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Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce α-synuclein phosphorylation in rat brain.
Danielle L Aubele, Roy K Hom, Marc Adler, Robert A Galemmo, Simeon Bowers, Ruth Motter

ChemMedChem· August 2013

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Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-β over Notch.
Gary Probst, Danielle L Aubele, Simeon Bowers, Darren Dressen, Albert W Garofalo, Ruth N Motter

J Med Chem· July 2013

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Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors.
Simeon Bowers, Anh P Truong, Michael Ye, Danielle L Aubele, Jennifer M Sealy, Ruth Motter

Bioorg Med Chem Lett· May 2013

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Development of an enzyme-linked immunosorbent assay (ELISA) to measure the level of tyrosine hydroxylase protein in brain tissue from Parkinson's disease models.
Donald Fauss, Ruth Motter, Lilibeth Dofiles, Maria Armanda Viana Rodrigues, Monica You

J Neurosci Methods· May 2013

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Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors.
Albert W Garofalo, Marc Adler, Danielle L Aubele, Elizabeth F Brigham, David Chian, Ruth Motter

Bioorg Med Chem Lett· April 2013

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Development and validation of immunoassays to quantify the half-antibody exchange of an IgG4 antibody, natalizumab (Tysabri®) with endogenous IgG4.
Renée I Shapiro, Tatiana Plavina, Brian R Schlain, R Blake Pepinsky, Ellen A Garber, Ruth Motter

J Pharm Biomed Anal· April 2011

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Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.
Guriqbal S Basi, Susanna Hemphill, Elizabeth F Brigham, Anna Liao, Danielle L Aubele, Ruth Motter

Alzheimers Res Ther· December 2010

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Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model.
Anh P Truong, Gergley Tóth, Gary D Probst, Jennifer M Sealy, Simeon Bowers, Ruth N Motter

Bioorg Med Chem Lett· November 2010

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A single ascending dose study of bapineuzumab in patients with Alzheimer disease.
Ronald S Black, Reisa A Sperling, Beth Safirstein, Ruth N Motter, Allan Pallay

Alzheimer Dis Assoc Disord· August 2010

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Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system.
Kelly J Inglis, David Chereau, Elizabeth F Brigham, San-San Chiou, Susanne Schöbel, Ruth Motter

J Biol Chem· January 2009

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Antibody capture of soluble Abeta does not reduce cortical Abeta amyloidosis in the PDAPP mouse.
Peter Seubert, Robin Barbour, Karen Khan, Ruth Motter, Pearl Tang

Neurodegener Dis· April 2008

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Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice.
Lisa McConlogue, Manuel Buttini, John P Anderson, Elizabeth F Brigham, Karen S Chen, Ruth Motter

J Biol Chem· September 2007

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Active beta-amyloid immunization restores spatial learning in PDAPP mice displaying very low levels of beta-amyloid.
Guiquan Chen, Karen S Chen, Dione Kobayashi, Robin Barbour, Ruth Motter

J Neurosci· March 2007

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Distribution of Abeta peptide in whole blood.
J Randall Slemmon, Cory L Painter, Sashi Nadanaciva, Florentina Catana, Ashley Cook, Ruth Motter

J Chromatogr B Analyt Technol Biomed Life Sci· February 2007

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Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease.
Manuel Buttini, Eliezer Masliah, Robin Barbour, Henry Grajeda, Ruth Motter

J Neurosci· October 2005

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Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology.
Frédérique Bard, Robin Barbour, Catherine Cannon, Robert Carretto, Michael Fox, Ruth Motter

Proc Natl Acad Sci U S A· February 2003

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