Publications by authors named "Ryan Pelis"

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Primary Small Intestinal Epithelia Are Physiological Alternatives to the Caco-2 Lymphatic Transport Model.
Ian M Smith, Oljora Rezhdo, Meihui Pan, Mitesh Patel, Nichola Smith, Ryan M Pelis

Mol Pharm· December 2025

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Utility of an lymphatics on-chip model for rank ordering subcutaneous absorption of monoclonal antibodies.
Adriana Martinez Ledo, Gabriela Misiewicz, Thomas Dimke, William R Tschantz, Jillian Handel, Ryan Pelis

Lab Chip· September 2025

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Improving accuracy in food effect predictions: Application of in-vitro absorption experiments as a useful tool for the evaluation of ten drug products.
Gobardhan Bal, Cornelius Harlacher, Dominic Werthmueller, Ioannis Loisios-Konstantinidis, Katarina Vulic, Ryan Pelis

Eur J Pharm Biopharm· June 2025

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Physiologically based pharmacokinetic modeling of midostaurin and metabolites at steady-state to bridge drug interaction scenarios in lieu of clinical trials.
Helen Gu, Romain Sechaud, Imad Hanna, Ryan Pelis, Heidi J Einolf

Drug Metab Dispos· March 2025

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Incubation Time Influences Organic Anion Transporter 1 Kinetics and Renal Clearance Predictions.
Aaron O Buaben, Ryan M Pelis

J Xenobiot· May 2023

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MATE1 Deficiency Exacerbates Dofetilide-Induced Proarrhythmia.
Muhammad Erfan Uddin, Eric D Eisenmann, Yang Li, Kevin M Huang, Dominique A Garrison, Ryan M Pelis

Int J Mol Sci· August 2022

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Quantitative Proteomics and Mechanistic Modeling of Transporter-Mediated Disposition in Nonalcoholic Fatty Liver Disease.
Anna Vildhede, Emi Kimoto, Ryan M Pelis, A David Rodrigues, Manthena V S Varma

Clin Pharmacol Ther· May 2020

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Influence of age on intestinal bile acid transport in C57BL/6 mice.
Tiandai Gao, Hirad A Feridooni, Susan E Howlett, Ryan M Pelis

Pharmacol Res Perspect· April 2017

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ClC Channels and Transporters: Structure, Physiological Functions, and Implications in Human Chloride Channelopathies.
Diogo R Poroca, Ryan M Pelis, Valérie M Chappe

Front Pharmacol· March 2017

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Drug Transport by the Blood-Aqueous Humor Barrier of the Eye.
Jonghwa Lee, Ryan M Pelis

Drug Metab Dispos· October 2016

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Organic Anion Transporter 1 Is Inhibited by Multiple Mechanisms and Shows a Transport Mode Independent of Exchange.
Adam G Hotchkiss, Tiandai Gao, Usman Khan, Liam Berrigan, Mansong Li, Ryan M Pelis

Drug Metab Dispos· December 2015

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Organic anion transporter 2 transcript variant 1 shows broad ligand selectivity when expressed in multiple cell lines.
Adam G Hotchkiss, Liam Berrigan, Ryan M Pelis

Front Pharmacol· October 2015

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A renal-like organic anion transport system in the ciliary epithelium of the bovine and human eye.
Jonghwa Lee, Mohammad Shahidullah, Adam Hotchkiss, Miguel Coca-Prados, Nicholas A Delamere, Ryan M Pelis

Mol Pharmacol· April 2015

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SLC22, SLC44, and SLC47 transporters--organic anion and cation transporters: molecular and cellular properties.
Ryan M Pelis, Stephen H Wright

Curr Top Membr· November 2014

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A plasma concentration of α-ketoglutarate influences the kinetic interaction of ligands with organic anion transporter 1.
Leslie Ingraham, Mansong Li, J Larry Renfro, Sonda Parker, Arpine Vapurcuyan, Ryan M Pelis

Mol Pharmacol· July 2014

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Cystic fibrosis transmembrane conductance regulator dysfunction in VIP knockout mice.
Nicole G Alcolado, Dustin J Conrad, Diogo Poroca, Mansong Li, Walaa Alshafie, Ryan M Pelis

Am J Physiol Cell Physiol· July 2014

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Transgenic expression of the human MRP2 transporter reduces cisplatin accumulation and nephrotoxicity in Mrp2-null mice.
Xia Wen, Brian Buckley, Elizabeth McCandlish, Michael J Goedken, Samira Syed, Ryan Pelis

Am J Pathol· May 2014

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Functional significance of conserved cysteines in the human organic cation transporter 2.
Ryan M Pelis, Yodying Dangprapai, Yaofeng Cheng, Xiaohong Zhang, Jennifer Terpstra

Am J Physiol Renal Physiol· July 2012

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Expression of organic anion transporter 2 in the human kidney and its potential role in the tubular secretion of guanine-containing antiviral drugs.
Yaofeng Cheng, Arpine Vapurcuyan, Mohammad Shahidullah, Lauren M Aleksunes, Ryan M Pelis

Drug Metab Dispos· March 2012

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Renal transport of organic anions and cations.
Ryan M Pelis, Stephen H Wright

Compr Physiol· October 2011

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Differences in the substrate binding regions of renal organic anion transporters 1 (OAT1) and 3 (OAT3).
Bethzaida Astorga, Theresa M Wunz, Mark Morales, Stephen H Wright, Ryan M Pelis

Am J Physiol Renal Physiol· August 2011

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Localization of multidrug resistance-associated protein 2 in the nonpigmented ciliary epithelium of the eye.
Ryan M Pelis, Mohammad Shahidullah, Sikha Ghosh, Miguel Coca-Prados, Stephen H Wright

J Pharmacol Exp Ther· May 2009

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Studies on bicarbonate transporters and carbonic anhydrase in porcine nonpigmented ciliary epithelium.
Mohammad Shahidullah, Chi-Ho To, Ryan M Pelis, Nicholas A Delamere

Invest Ophthalmol Vis Sci· April 2009

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Influence of estrogen and xenoestrogens on basolateral uptake of tetraethylammonium by opossum kidney cells in culture.
Ryan M Pelis, Randall C Hartman, Stephen H Wright, Theresa M Wunz, Carlotta E Groves

J Pharmacol Exp Ther· November 2007

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Inorganic mercury interacts with cysteine residues (C451 and C474) of hOCT2 to reduce its transport activity.
Ryan M Pelis, Yodying Dangprapai, Theresa M Wunz, Stephen H Wright

Am J Physiol Renal Physiol· May 2007

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