Publications by authors named "Ryan Roark"

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Prefusion structure, evasion and neutralization of HSV-1 glycoprotein B.
Ryan S Roark, Andrew J Schaub, Wei Shi, Maple Wang, Fabiana A Bahna

Nat Microbiol· November 2025

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Deep Mining of the Human Antibody Repertoire Identifies Frequent and Genetically Diverse CDRH3 Topologies Targetable by Vaccination.
Rumi Habib, Shahlo O Solieva, Zi Jie Lin, Sukanya Ghosh, Kelly Bayruns, Ryan S Roark

bioRxiv· November 2025

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Structural and genetic basis of HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodies.
Ryan S Roark, Rumi Habib, Jason Gorman, Hui Li, Andrew Jesse Connell

J Exp Med· October 2025

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Vaccine Elicitation of HIV-1 Neutralizing Antibodies Against Both V2 Apex and Fusion Peptide in Rhesus Macaques.
Hongying Duan, Joseph P Nkolola, Shuishu Wang, Jayeshbhai Chaudhari, I-Ting Teng, Ryan S Roark

bioRxiv· October 2025

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Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques.
Nitesh Mishra, Bo Liang, Ryan S Roark, Amrit Ghosh, Sean Callaghan

bioRxiv· October 2025

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Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV-1 V2 apex broadly neutralizing antibody development.
Rumi Habib, Ryan S Roark, Hui Li, Andrew Jesse Connell, Michael P Hogarty

bioRxiv· September 2025

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Transient glycan shield reduction induces CD4-binding site broadly neutralizing antibodies in SHIV-infected macaques.
Daniel J Morris, Jason Gorman, Tongqing Zhou, Jinery Lora, Andrew J Connell, Ryan S Roark

Cell Rep· June 2025

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Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunization.
Amrit Raj Ghosh, Rumi Habib, Nitesh Mishra, Ryan S Roark, Madhav Akauliya

bioRxiv· June 2025

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Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques.
Hua Wang, Cheng Cheng, James L Dal Santo, Chen-Hsiang Shen, Tatsiana Bylund, Ryan S Roark

Cell· December 2024

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Transient glycan-shield reduction induces CD4-binding site broadly neutralizing antibodies in SHIV-infected macaques.
Daniel J Morris, Jason Gorman, Tongqing Zhou, Jinery Lora, Andrew J Connell, Ryan S Roark

bioRxiv· December 2024

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Ultrapotent Broadly Neutralizing Human-llama Bispecific Antibodies against HIV-1.
Jianliang Xu, Tongqing Zhou, Krisha McKee, Baoshan Zhang, Cuiping Liu, Ryan S Roark

Adv Sci (Weinh)· July 2024

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HIV-1 neutralizing antibodies in SHIV-infected macaques recapitulate structurally divergent modes of human V2 apex recognition with a single D gene.
Ryan S Roark, Rumi Habib, Jason Gorman, Hui Li, Andrew Jesse Connell

bioRxiv· June 2024

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A Germline-Targeting Chimpanzee SIV Envelope Glycoprotein Elicits a New Class of V2-Apex Directed Cross-Neutralizing Antibodies.
Frederic Bibollet-Ruche, Ronnie M Russell, Wenge Ding, Weimin Liu, Yingying Li, Ryan S Roark

mBio· February 2023

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New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention and Cure.
Hui Li, Shuyi Wang, Fang-Hua Lee, Ryan S Roark, Alex I Murphy

J Virol· May 2021

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Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.
Ryan S Roark, Hui Li, Wilton B Williams, Hema Chug, Rosemarie D Mason

Science· January 2021

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Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting.
Nicole A Doria-Rose, Han R Altae-Tran, Ryan S Roark, Stephen D Schmidt, Matthew S Sutton

PLoS Pathog· January 2017

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New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency.
Nicole A Doria-Rose, Jinal N Bhiman, Ryan S Roark, Chaim A Schramm, Jason Gorman

J Virol· January 2016

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Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies.
Nicole A Doria-Rose, Chaim A Schramm, Jason Gorman, Penny L Moore, Jinal N Bhiman, Ryan S Roark

Nature· May 2014

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Complex regulation controls Neurogenin3 proteolysis.
Ryan Roark, Laura Itzhaki, Anna Philpott

Biol Open· December 2012

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Neurosteroid binding to the amino terminal and glutamate binding domains of ionotropic glutamate receptors.
Krasnodara Cameron, Emily Bartle, Ryan Roark, David Fanelli, Melissa Pham

Steroids· June 2012

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Mechanism of increased coxsackie and adenovirus receptor gene expression and adenovirus uptake by phytoestrogen and histone deacetylase inhibitor in human bladder cancer cells and the potential clinical application.
Rey-Chen Pong, Ryan Roark, Jiun-Yih Ou, Jianhai Fan, Jennifer Stanfield

Cancer Res· September 2006

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