Publications by authors named "Sabrina Zhao"

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Metabolism of a dopamine receptor partial agonist in rats, including an unusual N-dearylation reaction.
Sabrina X Zhao, Wendy Weiwei Wang, Gregory S Walker, Liming Zhang, R Scott Obach

Drug Metab Pharmacokinet· June 2011

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Discovery tactics to mitigate toxicity risks due to reactive metabolite formation with 2-(2-hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3h)-one derivatives, potent calcium-sensing receptor antagonists and clinical candidate(s) for the treatment of osteoporosis.
Amit S Kalgutkar, David A Griffith, Tim Ryder, Hao Sun, Zhuang Miao, Sabrina X Zhao

Chem Res Toxicol· June 2010

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Can in vitro metabolism-dependent covalent binding data distinguish hepatotoxic from nonhepatotoxic drugs? An analysis using human hepatocytes and liver S-9 fraction.
Jonathon N Bauman, Joan M Kelly, Sakambari Tripathy, Sabrina X Zhao, Wing W Lam

Chem Res Toxicol· February 2009

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Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): structure-activity relationships and strategies for the elimination of reactive metabolite formation.
Daniel P Walker, F Christopher Bi, Amit S Kalgutkar, Jonathan N Bauman, Sabrina X Zhao

Bioorg Med Chem Lett· December 2008

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High throughput ADME screening: practical considerations, impact on the portfolio and enabler of in silico ADME models.
Cornelis E C A Hop, Mark J Cole, Ralph E Davidson, David B Duignan, James Federico, Sabrina X Zhao

Curr Drug Metab· November 2008

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Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose.
R Scott Obach, Amit S Kalgutkar, John R Soglia, Sabrina X Zhao

Chem Res Toxicol· September 2008

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A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4-arylthiazole motif.
Amit S Kalgutkar, James Driscoll, Sabrina X Zhao, Gregory S Walker, Richard M Shepard

Chem Res Toxicol· December 2007

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Role of transporters in the disposition of the selective phosphodiesterase-4 inhibitor (+)-2-[4-({[2-(benzo[1,3]dioxol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid in rat and human.
Amit S Kalgutkar, Bo Feng, Hang T Nguyen, Kosea S Frederick, Scott D Campbell, Sabrina X Zhao

Drug Metab Dispos· November 2007

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NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine.
Sabrina X Zhao, Deepak K Dalvie, Joan M Kelly, John R Soglia, Kosea S Frederick

Chem Res Toxicol· November 2007

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Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship.
Donn G Wishka, Daniel P Walker, Karen M Yates, Steven C Reitz, Shaojuan Jia, Sabrina X Zhao

J Med Chem· July 2006

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A 96-well efflux assay to identify ABCG2 substrates using a stably transfected MDCK II cell line.
Yongling Xiao, Ralph Davidson, Arthur Smith, Dennis Pereira, Sabrina Zhao

Mol Pharm· June 2006

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A semiquantitative method for the determination of reactive metabolite conjugate levels in vitro utilizing liquid chromatography-tandem mass spectrometry and novel quaternary ammonium glutathione analogues.
John R Soglia, Leonard G Contillo, Amit S Kalgutkar, Sabrina Zhao, Cornelis E C A Hop

Chem Res Toxicol· March 2006

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Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4.
Amit S Kalgutkar, Kirk R Henne, Mary E Lame, Alfin D N Vaz, Claire Collin, Sabrina X Zhao

Chem Biol Interact· June 2005

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Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4.
Amit S Kalgutkar, Alfin D N Vaz, Mary E Lame, Kirk R Henne, John Soglia, Sabrina X Zhao

Drug Metab Dispos· February 2005

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Simple strategies for reducing sample loads in in vitro metabolic stability high-throughput screening experiments: a comparison between traditional, two-time-point and pooled sample analyses.
Sabrina X Zhao, Darcy Forman, Nora Wallace, Bill J Smith, Daniel Meyer

J Pharm Sci· January 2005

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The development of a higher throughput reactive intermediate screening assay incorporating micro-bore liquid chromatography-micro-electrospray ionization-tandem mass spectrometry and glutathione ethyl ester as an in vitro conjugating agent.
John R Soglia, Shawn P Harriman, Sabrina Zhao, John Barberia, Mark J Cole

J Pharm Biomed Anal· September 2004

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