Publications by authors named "Sandra Lightle"

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Comparative functional characterization of canine IgG subclasses.
Lisa M Bergeron, Erin E McCandless, Steve Dunham, Bill Dunkle, Yaqi Zhu, Sandra Lightle

Vet Immunol Immunopathol· January 2014

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Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, part I: transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors.
Mark S Plummer, Joseph Cornicelli, Howard Roark, Donald J Skalitzky, Charles J Stankovic, Sandra Lightle

Bioorg Med Chem Lett· June 2013

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Discovery of potent selective bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model. Part II: optimization studies and demonstration of in vivo efficacy.
Mark S Plummer, Joseph Cornicelli, Howard Roark, Donald J Skalitzky, Charles J Stankovic, Sandra Lightle

Bioorg Med Chem Lett· June 2013

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Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC.
Joseph S Warmus, Cheryl L Quinn, Clarke Taylor, Sean T Murphy, Timothy A Johnson, Sandra Lightle

Bioorg Med Chem Lett· April 2012

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Mutations within a human IgG2 antibody form distinct and homogeneous disulfide isomers but do not affect Fc gamma receptor or C1q binding.
Sandra Lightle, Serdar Aykent, Nathan Lacher, Vesselin Mitaksov, Kristine Wells

Protein Sci· April 2010

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Expression, purification, characterization and crystallization of non- and phosphorylated states of JAK2 and JAK3 kinase domain.
Troii Hall, Thomas L Emmons, Jill E Chrencik, Jennifer A Gormley, Robin A Weinberg, Sandra A Lightle

Protein Expr Purif· January 2010

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Discovery of antibacterial biotin carboxylase inhibitors by virtual screening and fragment-based approaches.
Igor Mochalkin, J Richard Miller, Lakshmi Narasimhan, Venkataraman Thanabal, Paul Erdman, Sandra Lightle

ACS Chem Biol· June 2009

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Structural evidence for substrate-induced synergism and half-sites reactivity in biotin carboxylase.
Igor Mochalkin, J Richard Miller, Artem Evdokimov, Sandra Lightle, Chunhong Yan

Protein Sci· October 2008

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Structure of a small-molecule inhibitor complexed with GlmU from Haemophilus influenzae reveals an allosteric binding site.
Igor Mochalkin, Sandra Lightle, Lakshmi Narasimhan, Dirk Bornemeier, Michael Melnick

Protein Sci· March 2008

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Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor.
Igor Mochalkin, John D Knafels, Sandra Lightle

Protein Sci· March 2008

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Characterization of substrate binding and catalysis in the potential antibacterial target N-acetylglucosamine-1-phosphate uridyltransferase (GlmU).
Igor Mochalkin, Sandra Lightle, Yaqi Zhu, Jeffrey F Ohren, Cindy Spessard

Protein Sci· December 2007

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The structure of the carboxyltransferase component of acetyl-coA carboxylase reveals a zinc-binding motif unique to the bacterial enzyme.
Patrick Bilder, Sandra Lightle, Graeme Bainbridge, Jeffrey Ohren, Barry Finzel

Biochemistry· February 2006

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