Publications by authors named "Sarah Hymowitz"

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Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design.
James J Crawford, Jianwen Feng, Hans D Brightbill, Adam R Johnson, Matthew Wright, Sarah G Hymowitz

Bioorg Med Chem Lett· June 2023

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Structural basis for SHOC2 modulation of RAS signalling.
Nicholas P D Liau, Matthew C Johnson, Saeed Izadi, Luca Gerosa, Michal Hammel, Sarah G Hymowitz

Nature· September 2022

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Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies.
Cholpon Tilegenova, Saeed Izadi, Jianping Yin, Christine S Huang, Jiansheng Wu, Sarah G Hymowitz

MAbs· January 2021

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Dimerization Induced by C-Terminal 14-3-3 Binding Is Sufficient for BRAF Kinase Activation.
Nicholas P D Liau, Avinashnarayan Venkatanarayan, John G Quinn, Wilson Phung, Shiva Malek, Sarah G Hymowitz

Biochemistry· October 2020

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Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization.
Nicholas P D Liau, Timothy J Wendorff, John G Quinn, Micah Steffek, Wilson Phung, Sarah G Hymowitz

Nat Struct Mol Biol· February 2020

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Targeting the MAPK Pathway in RAS Mutant Cancers.
Sarah G Hymowitz, Shiva Malek

Cold Spring Harb Perspect Med· November 2018

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Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase.
Nicole Blaquiere, Georgette M Castanedo, Jason D Burch, Leonid M Berezhkovskiy, Hans Brightbill, Sarah G Hymowitz

J Med Chem· August 2018

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Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity.
Christine S Huang, Nina Oberbeck, Yi-Chun Hsiao, Peter Liu, Adam R Johnson, Sarah G Hymowitz

Structure· May 2018

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Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K).
Georgette M Castanedo, Nicole Blaquiere, Maureen Beresini, Brandon Bravo, Hans Brightbill, Sarah Hymowitz

J Med Chem· January 2017

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Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2.
Scott A Foster, Daniel M Whalen, Ayşegül Özen, Matthew J Wongchenko, JianPing Yin, Sarah G Hymowitz

Cancer Cell· April 2016

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Unveiling the Structural and Dynamic Nature of the Ubiquitin Code.
Paola Di Lello, Sarah G Hymowitz

Structure· April 2016

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Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834.
Wendy B Young, James Barbosa, Peter Blomgren, Meire C Bremer, James J Crawford, Sarah G Hymowitz

Bioorg Med Chem Lett· March 2015

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Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action.
Olivier René, Benjamin P Fauber, Gladys de Leon Boenig, Brenda Burton, Céline Eidenschenk, Sarah G Hymowitz

ACS Med Chem Lett· March 2015

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Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
Zhi-Fu Tao, Lisa Hasvold, Le Wang, Xilu Wang, Andrew M Petros, Sarah G Hymowitz

ACS Med Chem Lett· October 2014

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Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling.
Jacob R Haling, Jawahar Sudhamsu, Ivana Yen, Steve Sideris, Wendy Sandoval, Sarah G Hymowitz

Cancer Cell· September 2014

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Shining LIGHT on functional promiscuity in the TNF and TNFR superfamilies.
Daniel M Whalen, Sarah G Hymowitz

Structure· September 2014

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Reduction in lipophilicity improved the solubility, plasma-protein binding, and permeability of tertiary sulfonamide RORc inverse agonists.
Benjamin P Fauber, Olivier René, Gladys de Leon Boenig, Brenda Burton, Yuzhong Deng, Sarah G Hymowitz

Bioorg Med Chem Lett· August 2014

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Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc.
Benjamin P Fauber, Gladys de Leon Boenig, Brenda Burton, Céline Eidenschenk, Christine Everett, Sarah G Hymowitz

Bioorg Med Chem Lett· December 2013

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Dimerization of LTβR by LTα1β2 is necessary and sufficient for signal transduction.
Jawahar Sudhamsu, Jianping Yin, Eugene Y Chiang, Melissa A Starovasnik, Jane L Grogan, Sarah G Hymowitz

Proc Natl Acad Sci U S A· December 2013

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Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling.
XiaoDong Huang, James C McGann, Bob Y Liu, Rami N Hannoush, Jennie R Lill, Sarah G Hymowitz

Science· March 2013

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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.
Andrew J Souers, Joel D Leverson, Erwin R Boghaert, Scott L Ackler, Nathaniel D Catron, Sarah G Hymowitz

Nat Med· February 2013

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The crystal structure of the catalytic domain of the NF-κB inducing kinase reveals a narrow but flexible active site.
Gladys de Leon-Boenig, Krista K Bowman, Jianwen A Feng, Terry Crawford, Christine Everett, Sarah G Hymowitz

Structure· October 2012

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Loss of the tumor suppressor BAP1 causes myeloid transformation.
Anwesha Dey, Dhaya Seshasayee, Rajkumar Noubade, Dorothy M French, Jinfeng Liu, Sarah Hymowitz

Science· September 2012

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Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).
John A Flygare, Maureen Beresini, Nageshwar Budha, Helen Chan, Iris T Chan, Sarah G Hymowitz

J Med Chem· May 2012

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Phosphorylation-dependent activity of the deubiquitinase DUBA.
Oscar W Huang, Xiaolei Ma, JianPing Yin, Jeremy Flinders, Till Maurer, Sarah G Hymowitz

Nat Struct Mol Biol· January 2012

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