Publications by authors named "Scott M Porter"

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Identification of a peptide inhibitor for the histone methyltransferase WHSC1.
Michael J Morrison, P Ann Boriack-Sjodin, Kerren K Swinger, Tim J Wigle, Dipti Sadalge, Margaret Porter Scott

PLoS One· August 2018

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Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma.
Allison E Drew, Oscar Moradei, Suzanne L Jacques, Nathalie Rioux, Ann P Boriack-Sjodin, Margaret Porter Scott

Sci Rep· December 2017

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Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates.
P Ann Boriack-Sjodin, Lei Jin, Suzanne L Jacques, Allison Drew, Chris Sneeringer, Margaret Porter Scott

ACS Chem Biol· March 2016

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Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor.
Lorna H Mitchell, P Ann Boriack-Sjodin, Sherri Smith, Michael Thomenius, Nathalie Rioux, Margaret Porter Scott

ACS Med Chem Lett· February 2016

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A High-Throughput Mass Spectrometry Assay Coupled with Redox Activity Testing Reduces Artifacts and False Positives in Lysine Demethylase Screening.
Tim J Wigle, Kerren K Swinger, John E Campbell, Michael D Scholle, John Sherrill, Margaret Porter Scott

J Biomol Screen· July 2015

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A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.
Elayne Chan-Penebre, Kristy G Kuplast, Christina R Majer, P Ann Boriack-Sjodin, Tim J Wigle, Margaret Porter Scott

Nat Chem Biol· June 2015

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Reaction coupling between wild-type and disease-associated mutant EZH2.
Brooke M Swalm, Sarah K Knutson, Natalie M Warholic, Lei Jin, Kevin W Kuntz, Margaret Porter Scott

ACS Chem Biol· November 2014

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DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells.
Christine R Klaus, Dorothy Iwanowicz, Danielle Johnston, Carly A Campbell, Jesse J Smith, Margaret Porter Scott

J Pharmacol Exp Ther· September 2014

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Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor.
Aravind Basavapathruni, Edward J Olhava, Scott R Daigle, Carly A Therkelsen, Lei Jin, Margaret Porter Scott

Biopharm Drug Dispos· May 2014

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Adherence to glaucoma medication: the effect of interventions and association with personality type.
Michele C Lim, Mitchell R Watnik, Katrina R Imson, Scott M Porter, Alison M Granier

J Glaucoma· August 2013

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Potent inhibition of DOT1L as treatment of MLL-fusion leukemia.
Scott R Daigle, Edward J Olhava, Carly A Therkelsen, Aravind Basavapathruni, Lei Jin, Margaret Porter Scott

Blood· August 2013

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Convergent evolution of chromatin modification by structurally distinct enzymes: comparative enzymology of histone H3 Lys²⁷ methylation by human polycomb repressive complex 2 and vSET.
Brooke M Swalm, Kenneth K Hallenbeck, Christina R Majer, Lei Jin, Margaret Porter Scott

Biochem J· July 2013

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A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.
Sarah K Knutson, Tim J Wigle, Natalie M Warholic, Christopher J Sneeringer, Christina J Allain, Margaret Porter Scott

Nat Chem Biol· November 2012

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A687V EZH2 is a gain-of-function mutation found in lymphoma patients.
Christina R Majer, Lei Jin, Margaret Porter Scott, Sarah K Knutson, Kevin W Kuntz

FEBS Lett· September 2012

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Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905).
Matthew O Duffey, Tricia J Vos, Ruth Adams, Jennifer Alley, Justin Anthony, Margaret Porter Scott

J Med Chem· January 2012

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The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states.
Tim J Wigle, Sarah K Knutson, Lei Jin, Kevin W Kuntz, Roy M Pollock, Margaret Porter Scott

FEBS Lett· October 2011

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Impact of enzyme concentration and residence time on apparent activity recovery in jump dilution analysis.
Robert A Copeland, Aravind Basavapathruni, Mikel Moyer, Margaret Porter Scott

Anal Biochem· September 2011

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Chemogenetic analysis of human protein methyltransferases.
Victoria M Richon, Danielle Johnston, Christopher J Sneeringer, Lei Jin, Christina R Majer, Margaret Porter Scott

Chem Biol Drug Des· August 2011

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Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.
Scott R Daigle, Edward J Olhava, Carly A Therkelsen, Christina R Majer, Christopher J Sneeringer, Margaret Porter Scott

Cancer Cell· July 2011

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Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas.
Christopher J Sneeringer, Margaret Porter Scott, Kevin W Kuntz, Sarah K Knutson, Roy M Pollock

Proc Natl Acad Sci U S A· December 2010

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Targeting epigenetic enzymes for drug discovery.
Robert A Copeland, Edward J Olhava, Margaret Porter Scott

Curr Opin Chem Biol· August 2010

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An epinephrine-dependent mechanism for the control of UV-induced pigmentation.
Raja K Sivamani, Scott M Porter, R Rivkah Isseroff

J Invest Dermatol· March 2009

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A general technique to rank protein-ligand binding affinities and determine allosteric versus direct binding site competition in compound mixtures.
D Allen Annis, Naim Nazef, Cheng-Chi Chuang, Margaret Porter Scott, Huw M Nash

J Am Chem Soc· December 2004

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Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1.
Margaret Porter Scott, Francesca Zappacosta, Eun Young Kim, Roland S Annan, W Todd Miller

J Biol Chem· August 2002

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