Publications by authors named "Sean C Semple"

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Spatial profiling of gene editing by in situ sequencing in mice and macaques.
Sharan Janjuha, Tatjana Haenggi, Thomas C Chamberlain, Tanja Rothgangl, Lucas Kissling, Sean C Semple

Nat Biomed Eng· September 2025

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Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo.
Vladimir V Shuvaev, Ying K Tam, Benjamin W Lee, Jacob W Myerson, Alan Herbst, Sean C Semple

Proc Natl Acad Sci U S A· July 2025

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Physiologically based modeling of LNP-mediated delivery of mRNA in the vascular system.
Hamideh Parhiz, Vladimir V Shuvaev, Qin Li, Tyler E Papp, Awurama A Akyianu, Sean C Semple

Mol Ther Nucleic Acids· June 2024

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Targeting the hepatitis B cccDNA with a sequence-specific ARCUS nuclease to eliminate hepatitis B virus in vivo.
Cassandra L Gorsuch, Paige Nemec, Mei Yu, Simin Xu, Dong Han, Sean C Semple

Mol Ther· September 2022

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Lipid Nanoparticle Delivery Systems to Enable mRNA-Based Therapeutics.
Sean C Semple, Robert Leone, Christopher J Barbosa, Ying K Tam, Paulo J C Lin

Pharmaceutics· February 2022

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In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels.
Tanja Rothgangl, Melissa K Dennis, Paulo J C Lin, Rurika Oka, Dominik Witzigmann, Sean C Semple

Nat Biotechnol· August 2021

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The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs.
Akin Akinc, Martin A Maier, Muthiah Manoharan, Kevin Fitzgerald, Muthusamy Jayaraman, Sean C Semple

Nat Nanotechnol· December 2019

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Rational design of cationic lipids for siRNA delivery.
Sean C Semple, Akin Akinc, Jianxin Chen, Ammen P Sandhu, Barbara L Mui

Nat Biotechnol· February 2010

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Therapeutic integration of c-myc and bcl-2 antisense molecules with docetaxel in a preclinical model of hormone-refractory prostate cancer.
Carlo Leonetti, Annamaria Biroccio, Carmen D'Angelo, Sean C Semple, Marco Scarsella

Prostate· September 2007

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Characterization of the drug retention and pharmacokinetic properties of liposomal nanoparticles containing dihydrosphingomyelin.
Michael J W Johnston, Sean C Semple, Sandy K Klimuk, Steve Ansell, Norbert Maurer

Biochim Biophys Acta· May 2007

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Therapeutically optimized rates of drug release can be achieved by varying the drug-to-lipid ratio in liposomal vincristine formulations.
Michael J W Johnston, Sean C Semple, Sandra K Klimuk, Katarina Edwards, Merete L Eisenhardt

Biochim Biophys Acta· January 2006

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Optimization and characterization of a sphingomyelin/cholesterol liposome formulation of vinorelbine with promising antitumor activity.
Sean C Semple, Robert Leone, Jinfang Wang, Esther C Leng, Sandra K Klimuk

J Pharm Sci· May 2005

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Liposome-encapsulated vincristine, vinblastine and vinorelbine: a comparative study of drug loading and retention.
Igor V Zhigaltsev, Norbert Maurer, Quet-Fah Akhong, Robert Leone, Esther Leng, Sean C Semple

J Control Release· May 2005

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Immunogenicity and rapid blood clearance of liposomes containing polyethylene glycol-lipid conjugates and nucleic Acid.
Sean C Semple, Troy O Harasym, Kathy A Clow, Steven M Ansell, Sandra K Klimuk

J Pharmacol Exp Ther· March 2005

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Antitumor efficacy of bcl-2 and c-myc antisense oligonucleotides in combination with cisplatin in human melanoma xenografts: relevance of the administration sequence.
Gabriella Zupi, Marco Scarsella, Sean C Semple, Marcella Mottolese, Pier G Natali

Clin Cancer Res· March 2005

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Role of c-myc protein in hormone refractory prostate carcinoma: cellular response to paclitaxel.
Giuliana Cassinelli, Rosanna Supino, Valentina Zuco, Cinzia Lanzi, A Ivana Scovassi, Sean C Semple

Biochem Pharmacol· September 2004

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In vivo administration of liposomal vincristine sensitizes drug-resistant human solid tumors.
Carlo Leonetti, Marco Scarsella, Sean C Semple, Agnese Molinari, Carmen D'Angelo

Int J Cancer· July 2004

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High efficiency entrapment of antisense oligonucleotides in liposomes.
Darrin D Stuart, Sean C Semple, Theresa M Allen

Methods Enzymol· July 2004

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Epicutaneous application of CpG oligodeoxynucleotides with peptide or protein antigen promotes the generation of CTL.
Sandra K Klimuk, Hossain M Najar, Sean C Semple, Soudabeh Aslanian, Jan P Dutz

J Invest Dermatol· April 2004

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Targeted liposomal c-myc antisense oligodeoxynucleotides induce apoptosis and inhibit tumor growth and metastases in human melanoma models.
Fabio Pastorino, Chiara Brignole, Danilo Marimpietri, Gabriella Pagnan, Adriana Morando, Sean C Semple

Clin Cancer Res· October 2003

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