Publications by authors named "Sebastien A Burel"

Claim this Profile
A
Assessing Hybridization-Dependent Off-Target Risk for Therapeutic Oligonucleotides: Updated Industry Recommendations.
Patrik Andersson, Sebastien A Burel, Heather Estrella, Jeffrey Foy, Peter H Hagedorn

Nucleic Acid Ther· February 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Correlations between preclinical BJAB assay ranking of antisense drugs and clinical trial adverse events.
Wesley Partridge, Sebastien A Burel, Annie Ferng, Shuting Xia, T Jesse Kwoh

Clin Transl Sci· April 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Early-Stage Identification and Avoidance of Antisense Oligonucleotides Causing Species-Specific Inflammatory Responses in Human Volunteer Peripheral Blood Mononuclear Cells.
Sebastien A Burel, Todd Machemer, Brenda F Baker, T Jesse Kwoh, Suzanne Paz

Nucleic Acid Ther· December 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Inflammatory Non-CpG Antisense Oligonucleotides Are Signaling Through TLR9 in Human Burkitt Lymphoma B Bjab Cells.
Adam J Pollak, Patrick Cauntay, Todd Machemer, Suzanne Paz, Sagar Damle, Sebastien A Burel

Nucleic Acid Ther· December 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.
Brooke A Anderson, Graeme C Freestone, Audrey Low, Cheryl L De-Hoyos, William J Drury Iii, Sebastien A Burel

Nucleic Acids Res· September 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
U
Underlying Immune Disorder May Predispose Some Transthyretin Amyloidosis Subjects to Inotersen-Mediated Thrombocytopenia.
PadmaKumar Narayanan, Brian R Curtis, Lijiang Shen, Eugene Schneider, Joseph A Tami, Sebastien A Burel

Nucleic Acid Ther· April 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
Hybrid Mouse Diversity Panel Identifies Genetic Architecture Associated with the Acute Antisense Oligonucleotide-Mediated Inflammatory Response to a 2'--Methoxyethyl Antisense Oligonucleotide.
Elaine Pirie, Patrick Cauntay, Wuxia Fu, Shayoni Ray, Calvin Pan, Sebastien A Burel

Nucleic Acid Ther· October 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Comparison of the Class Effects of Antisense Oligonucleotides in CByB6F1-Tg(HRAS)2Jic and CD-1 Mice.
Tae-Won Kim, Chris N Papagiannis, Laura S Zwick, Jeffery A Engelhardt, Christine M Hoffmaster, Sebastien A Burel

Toxicol Pathol· January 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Investigation into the Mechanism(s) That Leads to Platelet Decreases in Cynomolgus Monkeys During Administration of ISIS 104838, a 2'-MOE-Modified Antisense Oligonucleotide.
Padmakumar Narayanan, Lijiang Shen, Brian R Curtis, Mario A Bourdon, John P Nolan, Sebastien A Burel

Toxicol Sci· August 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Assessment of the Effects of 2'-Methoxyethyl Antisense Oligonucleotides on Platelet Count in Cynomolgus Nonhuman Primates.
Scott P Henry, Padmakumar Narayanan, Lijiang Shen, Sanjay Bhanot, Husam S Younis, Sebastien A Burel

Nucleic Acid Ther· August 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Integrated Safety Assessment of 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers.
Stanley T Crooke, Brenda F Baker, T Jesse Kwoh, Wei Cheng, Dan J Schulz, Sebastien A Burel

Mol Ther· October 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts.
Sebastien A Burel, Christopher E Hart, Patrick Cauntay, Jill Hsiao, Todd Machemer

Nucleic Acids Res· March 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Comprehensive Structure-Activity Relationship of Triantennary N-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes.
Thazha P Prakash, Jinghua Yu, Michael T Migawa, Garth A Kinberger, W Brad Wan, Sebastien A Burel

J Med Chem· March 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Preclinical evaluation of the toxicological effects of a novel constrained ethyl modified antisense compound targeting signal transducer and activator of transcription 3 in mice and cynomolgus monkeys.
Sebastien A Burel, So-Ri Han, Hong-Soo Lee, Daniel A Norris, Byoung-Seok Lee

Nucleic Acid Ther· June 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
U
Unique O-methoxyethyl ribose-DNA chimeric oligonucleotide induces an atypical melanoma differentiation-associated gene 5-dependent induction of type I interferon response.
Sebastien A Burel, Todd Machemer, Frank L Ragone, Hiroki Kato, Patrick Cauntay

J Pharmacol Exp Ther· July 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development.
Ming Yan, Sebastien A Burel, Luke F Peterson, Eiki Kanbe, Hiromi Iwasaki

Proc Natl Acad Sci U S A· December 2004

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis