Publications by authors named "Sebastien Moniot"

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Reflectometric-based sensor arrays for the screening of kinase-inhibitor interactions and kinetic determination.
Viola Wurster, Peter Fechner, Günther Proll, Rebecca Pamies-Cuberos, Matthias Frech, Sébastien Moniot

Anal Bioanal Chem· December 2025

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Bispecific Antibody Detection Using Antigen-Conjugated Synthetic Nucleic Acid Strands.
Davide Mariottini, Sara Bracaglia, Luca Barbero, Sebastian W Fuchs, Christoph Saal, Sebastien Moniot

ACS Sens· November 2023

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Crystal structure of a class III adenylyl cyclase-like ATP-binding protein from Pseudomonas aeruginosa.
Juergen Linder, Enrico Hupfeld, Michael Weyand, Clemens Steegborn, Sébastien Moniot

J Struct Biol· August 2020

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A blue light receptor that mediates RNA binding and translational regulation.
Anna M Weber, Jennifer Kaiser, Thea Ziegler, Sebastian Pilsl, Christian Renzl, Sébastien Moniot

Nat Chem Biol· November 2019

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Effects of 3-Bromo-4,5-dihydroisoxazole Derivatives on Nrf2 Activation and Heme Oxygenase-1 Expression.
Andrea Pinto, Zeina El Ali, Sébastien Moniot, Lucia Tamborini, Clemens Steegborn

ChemistryOpen· November 2018

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KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.
Luisa Quinti, Sharadha Dayalan Naidu, Ulrike Träger, Xiqun Chen, Kimberly Kegel-Gleason, Sébastien Moniot

Proc Natl Acad Sci U S A· June 2017

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Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
Rita Machado de Oliveira, Hugo Vicente Miranda, Laetitia Francelle, Raquel Pinho, Éva M Szegö, Sébastien Moniot

PLoS Biol· April 2017

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Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket.
Sandeep Sundriyal, Sébastien Moniot, Zimam Mahmud, Shang Yao, Paolo Di Fruscia

J Med Chem· March 2017

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Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity.
Sébastien Moniot, Mariantonietta Forgione, Alessia Lucidi, Gebremedhin S Hailu, Angela Nebbioso

J Med Chem· March 2017

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The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
Rita Machado de Oliveira, Hugo Vicente Miranda, Laetitia Francelle, Raquel Pinho, Éva M Szegö, Sébastien Moniot

PLoS Biol· March 2017

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A conserved NAD binding pocket that regulates protein-protein interactions during aging.
Jun Li, Michael S Bonkowski, Sébastien Moniot, Dapeng Zhang, Basil P Hubbard

Science· March 2017

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SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models.
Luisa Quinti, Malcolm Casale, Sébastien Moniot, Teresa F Pais, Michael J Van Kanegan

Cell Chem Biol· July 2016

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1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells.
Sergio Valente, Paolo Mellini, Francesco Spallotta, Vincenzo Carafa, Angela Nebbioso, Sébastien Moniot

J Med Chem· February 2016

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The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
Xiqun Chen, Pauline Wales, Luisa Quinti, Fuxing Zuo, Sébastien Moniot

PLoS One· January 2016

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The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model.
Paolo Di Fruscia, Emmanouil Zacharioudakis, Chang Liu, Sébastien Moniot, Sasiwan Laohasinnarong

ChemMedChem· January 2015

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Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate.
Silke Kleinboelting, Ana Diaz, Sebastien Moniot, Joop van den Heuvel, Michael Weyand

Proc Natl Acad Sci U S A· March 2014

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Crystal structure analysis of human Sirt2 and its ADP-ribose complex.
Sébastien Moniot, Mike Schutkowski, Clemens Steegborn

J Struct Biol· May 2013

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Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol.
Mahadevan Lakshminarasimhan, Ute Curth, Sebastien Moniot, Shyamal Mosalaganti, Stefan Raunser

Biosci Rep· May 2013

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Structures, substrates, and regulators of Mammalian sirtuins - opportunities and challenges for drug development.
Sébastien Moniot, Michael Weyand, Clemens Steegborn

Front Pharmacol· October 2012

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Crystallization and preliminary crystal structure analysis of the ligand-binding domain of PqsR (MvfR), the Pseudomonas quinolone signal (PQS) responsive quorum-sensing transcription factor of Pseudomonas aeruginosa.
Ningna Xu, Shen Yu, Sébastien Moniot, Michael Weyand, Wulf Blankenfeldt

Acta Crystallogr Sect F Struct Biol Cryst Commun· September 2012

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Crystal structures of receptors involved in small molecule transport across membranes.
Haydar Bulut, Qingjun Ma, Sebastien Moniot, Wolfram Saenger, Erwin Schneider

Eur J Cell Biol· April 2012

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Crystal structures of N-acetylmannosamine kinase provide insights into enzyme activity and inhibition.
Jacobo Martinez, Long Duc Nguyen, Stephan Hinderlich, Reinhold Zimmer, Eva Tauberger, Sébastien Moniot

J Biol Chem· April 2012

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Crystal structures of two solute receptors for L-cystine and L-cysteine, respectively, of the human pathogen Neisseria gonorrhoeae.
Haydar Bulut, Sebastien Moniot, Anke Licht, Frank Scheffel, Stephanie Gathmann

J Mol Biol· January 2012

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Elucidation of the phosphate binding mode of DING proteins revealed by subangstrom X-ray crystallography.
Dorothee Liebschner, Mikael Elias, Sèbastien Moniot, Bertrand Fournier, Ken Scott

J Am Chem Soc· June 2009

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Structural basis for natural lactonase and promiscuous phosphotriesterase activities.
Mikael Elias, Jérôme Dupuy, Luigia Merone, Luigi Mandrich, Elena Porzio, Sébastien Moniot

J Mol Biol· June 2008

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