Publications by authors named "Sharon Shepherd"

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Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors.
Thomas C Eadsforth, Leah S Torrie, Paul Rowland, Emma V Edgar, Lorna M MacLean, Sharon M Shepherd

J Biol Chem· January 2025

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Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs.
Simon R Green, Susan H Davis, Sebastian Damerow, Curtis A Engelhart, Michael Mathieson, Sharon M Shepherd

Nat Commun· October 2022

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Toolkit of Approaches To Support Target-Focused Drug Discovery for Lysyl tRNA Synthetase.
Rachel Milne, Natalie Wiedemar, Victoriano Corpas-Lopez, Eoin Moynihan, Richard J Wall, Sharon M Shepherd

ACS Infect Dis· September 2022

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Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention.
Robert L Summers, Charisse Flerida A Pasaje, Joao P Pisco, Josefine Striepen, Madeline R Luth, Andrew M Shepherd, Sharon M Shepherd

Cell Chem Biol· February 2022

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Association between changes in Membership and Professional Standards Committee review criteria and use of higher-risk kidneys for transplant.
Andrew Wey, Nicholas Salkowski, Robert J Carrico, Sharon Shepherd, Bertram L Kasiske

Clin Transplant· July 2020

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Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase.
Leah S Torrie, David A Robinson, Michael G Thomas, Judith V Hobrath, Sharon M Shepherd

ACS Infect Dis· May 2020

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Phosphomannomutase and Guanosine Diphosphate-Mannose Pyrophosphorylase Ligandability Assessment.
Filip Zmuda, Sharon M Shepherd, Michael A J Ferguson, David W Gray, Leah S Torrie

Antimicrob Agents Chemother· October 2019

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Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay.
Filip Zmuda, Lalitha Sastry, Sharon M Shepherd, Deuan Jones, Alison Scott

Antimicrob Agents Chemother· September 2019

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Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Beatriz Baragaña, Barbara Forte, Ryan Choi, Stephen Nakazawa Hewitt, Juan A Bueren-Calabuig, Sharon M Shepherd

Proc Natl Acad Sci U S A· April 2019

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Identification of UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening.
Ohm Prakash, Jana Führing, John Post, Sharon M Shepherd, Thomas C Eadsforth

Molecules· March 2019

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Structure of Pseudomonas aeruginosa inosine 5'-monophosphate dehydrogenase.
Vincenzo A Rao, Sharon M Shepherd, Richard Owen, William N Hunter

Acta Crystallogr Sect F Struct Biol Cryst Commun· March 2013

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Pseudomonas aeruginosa 4-amino-4-deoxychorismate lyase: spatial conservation of an active site tyrosine and classification of two types of enzyme.
Patrick E F O'Rourke, Thomas C Eadsforth, Paul K Fyfe, Sharon M Shepherd, William N Hunter

PLoS One· April 2012

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The structure of Serratia marcescens Lip, a membrane-bound component of the type VI secretion system.
Vincenzo A Rao, Sharon M Shepherd, Grant English, Sarah J Coulthurst, William N Hunter

Acta Crystallogr D Biol Crystallogr· December 2011

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Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms.
Sarah Sainsbury, Louise Bird, Vincenzo Rao, Sharon M Shepherd, David I Stuart

J Mol Biol· January 2011

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Molecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferase.
Ramon Hurtado-Guerrero, Tal Zusman, Shalini Pathak, Adel F M Ibrahim, Sharon Shepherd

Biochem J· February 2010

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Molecular mechanisms of yeast cell wall glucan remodeling.
Ramon Hurtado-Guerrero, Alexander W Schüttelkopf, Isabelle Mouyna, Adel F M Ibrahim, Sharon Shepherd

J Biol Chem· March 2009

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Structural and kinetic differences between human and Aspergillus fumigatus D-glucosamine-6-phosphate N-acetyltransferase.
Ramon Hurtado-Guerrero, Olawale G Raimi, Jinrong Min, Hong Zeng, Laura Vallius, Sharon Shepherd

Biochem J· October 2008

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Structural insights into mechanism and specificity of O-GlcNAc transferase.
Andrew J Clarke, Ramon Hurtado-Guerrero, Shalini Pathak, Alexander W Schüttelkopf, Vladimir Borodkin, Sharon M Shepherd

EMBO J· October 2008

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Glucose-6-phosphate as a probe for the glucosamine-6-phosphate N-acetyltransferase Michaelis complex.
Ramon Hurtado-Guerrero, Olawale Raimi, Sharon Shepherd, Daan M F van Aalten

FEBS Lett· December 2007

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GlcNAcstatin: a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels.
Helge C Dorfmueller, Vladimir S Borodkin, Marianne Schimpl, Sharon M Shepherd, Natalia A Shpiro

J Am Chem Soc· December 2006

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TAK1-binding protein 1 is a pseudophosphatase.
Sarah H Conner, Gursant Kular, Mark Peggie, Sharon Shepherd, Alexander W Schüttelkopf

Biochem J· November 2006

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