Publications by authors named "Shaun Fillery"

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Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS with Demonstrable CNS Penetration.
Jason G Kettle, Sharan K Bagal, Derek Barratt, Michael S Bodnarchuk, Scott Boyd, Shaun Fillery

J Med Chem· July 2023

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Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS.
Jason G Kettle, Sharan K Bagal, Sue Bickerton, Michael S Bodnarchuk, Scott Boyd, Shaun Fillery

J Med Chem· May 2022

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Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models.
Jon J Winter-Holt, Catherine Bardelle, Elisabetta Chiarparin, Ian L Dale, Paul R J Davey, Shaun M Fillery

J Med Chem· February 2022

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Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase.
Sharan K Bagal, Clare Gregson, Daniel H O' Donovan, Kurt G Pike, Andrew Bloecher, Shaun M Fillery

J Med Chem· December 2021

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Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase.
Daniel H O' Donovan, Clare Gregson, Martin J Packer, Ryan Greenwood, Kurt G Pike, Shaun Fillery

Bioorg Med Chem Lett· May 2021

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A Buchwald-Hartwig Protocol to Enable Rapid Linker Exploration of Cereblon E3-Ligase PROTACs*.
Thomas G Hayhow, Rachel E A Borrows, Coura R Diène, Gary Fairley, Charlene Fallan, Shaun M Fillery

Chemistry· December 2020

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Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS.
Jason G Kettle, Sharan K Bagal, Sue Bickerton, Michael S Bodnarchuk, Jason Breed, Shaun Fillery

J Med Chem· May 2020

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Expeditious Access to Functionalized Tricyclic Pyrrolo-Pyridones via Tandem or Sequential C-N/C-C Bond Formations.
Shaun M Fillery, Clare L Gregson, Carine M Guérot

Org Lett· November 2019

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Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6.
William McCoull, Tony Cheung, Erica Anderson, Peter Barton, Jonathan Burgess, Shaun Fillery

ACS Chem Biol· November 2018

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Correction to Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
William McCoull, Roman D Abrams, Erica Anderson, Kevin Blades, Peter Barton, Shaun Fillery

J Med Chem· July 2017

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Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
William McCoull, Roman D Abrams, Erica Anderson, Kevin Blades, Peter Barton, Shaun Fillery

J Med Chem· May 2017

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Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival.
Jason G Kettle, Husam Alwan, Michal Bista, Jason Breed, Nichola L Davies, Shaun Fillery

J Med Chem· March 2016

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Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis.
Jason G Kettle, Peter Ballard, Catherine Bardelle, Mark Cockerill, Nicola Colclough, Shaun Fillery

J Med Chem· March 2015

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Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity.
Kevin M Foote, Kevin Blades, Anna Cronin, Shaun Fillery, Sylvie S Guichard

J Med Chem· March 2013

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Sulfonyl-morpholino-pyrimidines: SAR and development of a novel class of selective mTOR kinase inhibitor.
M Raymond V Finlay, David Buttar, Susan E Critchlow, Allan P Dishington, Shaun M Fillery

Bioorg Med Chem Lett· June 2012

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Diverse heterocyclic scaffolds as allosteric inhibitors of AKT.
Jason G Kettle, Simon Brown, Claire Crafter, Barry R Davies, Phillippa Dudley, Shaun Fillery

J Med Chem· February 2012

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Mechanistic studies on the synthesis of bicalutamide.
Nabil Asaad, Shaun Fillery

Org Biomol Chem· February 2009

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Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas.
Jeremy N Burrows, John G Cumming, Shaun M Fillery, Gordon A Hamlin, Julian A Hudson

Bioorg Med Chem Lett· January 2005

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Amination of ethers using chloramine-T hydrate and a copper(I) catalyst.
David P Albone, Stephen Challenger, Andrew M Derrick, Shaun M Fillery, Jacob L Irwin

Org Biomol Chem· January 2005

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