Publications by authors named "Shirley Sutton"

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Epistasis regulates genetic control of cardiac hypertrophy.
Qianru Wang, Tiffany M Tang, Michelle Youlton, Chad S Weldy, Ana M Kenney, Shirley C Sutton

Nat Cardiovasc Res· June 2025

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Deciphering epistatic genetic regulation of cardiac hypertrophy.
Qianru Wang, Tiffany M Tang, Michelle Youlton, Chad S Weldy, Ana M Kenney, Shirley C Sutton

medRxiv· April 2025

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Regional Variation in Cardiovascular Genes Enables a Tractable Genome Editing Strategy.
Vikki A Krysov, Rachel H Wilson, Nicholas S Ten, Nathan Youlton, Hannah N De Jong, Shirley Sutton

Circ Genom Precis Med· April 2024

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Epistasis regulates genetic control of cardiac hypertrophy.
Qianru Wang, Tiffany M Tang, Nathan Youlton, Chad S Weldy, Ana M Kenney, Shirley C Sutton

Res Sq· November 2023

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Deconvoluting complex correlates of COVID-19 severity with a multi-omic pandemic tracking strategy.
Victoria N Parikh, Alexander G Ioannidis, David Jimenez-Morales, John E Gorzynski, Hannah N De Jong, Shirley C Sutton

Nat Commun· August 2022

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Mono- and Biallelic Protein-Truncating Variants in Alpha-Actinin 2 Cause Cardiomyopathy Through Distinct Mechanisms.
Malene E Lindholm, David Jimenez-Morales, Han Zhu, Kinya Seo, David Amar, Shirley Sutton

Circ Genom Precis Med· December 2021

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High-throughput SARS-CoV-2 and host genome sequencing from single nasopharyngeal swabs.
John E Gorzynski, Hannah N De Jong, David Amar, Chris R Hughes, Alexander Ioannidis, Shirley Sutton

medRxiv· September 2020

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Genetic variation drives seasonal onset of hibernation in the 13-lined ground squirrel.
Katharine R Grabek, Thomas F Cooke, L Elaine Epperson, Kaitlyn K Spees, Gleyce F Cabral, Shirley C Sutton

Commun Biol· July 2020

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Allele-Specific Silencing Ameliorates Restrictive Cardiomyopathy Attributable to a Human Myosin Regulatory Light Chain Mutation.
Kathia Zaleta-Rivera, Alexandra Dainis, Alexandre J S Ribeiro, Pablo Cordero, Gabriel Rubio, Shirley Sutton

Circulation· August 2019

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The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations.
Suman Nag, Darshan V Trivedi, Saswata S Sarkar, Arjun S Adhikari, Margaret S Sunitha, Shirley Sutton

Nat Struct Mol Biol· June 2017

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Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy.
Masataka Kawana, Saswata S Sarkar, Shirley Sutton, Kathleen M Ruppel, James A Spudich

Sci Adv· February 2017

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Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin.
James A Spudich, Tural Aksel, Sadie R Bartholomew, Suman Nag, Masataka Kawana, Shirley Sutton

J Exp Biol· January 2016

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Establishing disease causality for a novel gene variant in familial dilated cardiomyopathy using a functional in-vitro assay of regulated thin filaments and human cardiac myosin.
Stephen Pan, Ruth F Sommese, Karim I Sallam, Suman Nag, Shirley Sutton

BMC Med Genet· October 2015

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Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function.
Suman Nag, Ruth F Sommese, Zoltan Ujfalusi, Ariana Combs, Stephen Langer, Shirley Sutton

Sci Adv· October 2015

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Harmonic force spectroscopy measures load-dependent kinetics of individual human β-cardiac myosin molecules.
Jongmin Sung, Suman Nag, Kim I Mortensen, Christian L Vestergaard, Shirley Sutton

Nat Commun· August 2015

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Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effector.
Tural Aksel, Elizabeth Choe Yu, Shirley Sutton, Kathleen M Ruppel, James A Spudich

Cell Rep· May 2015

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Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin.
Ruth F Sommese, Suman Nag, Shirley Sutton, Susan M Miller, James A Spudich

PLoS One· October 2014

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Observation of correlated X-ray scattering at atomic resolution.
Derek Mendez, Thomas J Lane, Jongmin Sung, Jonas Sellberg, Clément Levard, Shirley Sutton

Philos Trans R Soc Lond B Biol Sci· July 2014

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Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function.
Ruth F Sommese, Jongmin Sung, Suman Nag, Shirley Sutton, John C Deacon

Proc Natl Acad Sci U S A· July 2013

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EPR spectra and molecular dynamics agree that the nucleotide pocket of myosin V is closed and that it opens on binding actin.
Thomas J Purcell, Nariman Naber, Shirley Sutton, Roger Cooke, Edward Pate

J Mol Biol· August 2011

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Dictyostelium myosin bipolar thick filament formation: importance of charge and specific domains of the myosin rod.
Daniel Hostetter, Sarah Rice, Sara Dean, David Altman, Peggy M McMahon, Shirley Sutton

PLoS Biol· November 2004

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