Publications by authors named "Shiro Takekawa"

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Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms.
Mie Suzuki Okutani, Shinya Okamura, Tang Gis, Hitomi Sasaki, Suni Lee, Shiro Takekawa

Elife· February 2025

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Versatile live-attenuated SARS-CoV-2 vaccine platform applicable to variants induces protective immunity.
Akiho Yoshida, Shinya Okamura, Shiho Torii, Sayuri Komatsu, Paola Miyazato, Shiro Takekawa

iScience· November 2022

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Inhibition of MGAT2 modulates fat-induced gut peptide release and fat intake in normal mice and ameliorates obesity and diabetes in ob/ob mice fed on a high-fat diet.
Taisuke Mochida, Kazumi Take, Toshiyuki Maki, Masanori Nakakariya, Ryutaro Adachi, Shiro Takekawa

FEBS Open Bio· March 2020

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Identification and Characterization of a New Series of Ghrelin O-Acyl Transferase Inhibitors.
Mariko Yoneyama-Hirozane, Kohei Deguchi, Takeshi Hirakawa, Tsuyoshi Ishii, Tomoyuki Odani, Shiro Takekawa

SLAS Discov· February 2018

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Antiobesity and emetic effects of a short-length peptide YY analog and its PEGylated and alkylated derivatives.
Ayumu Niida, Yoko Kanematsu-Yamaki, Tomoko Asakawa, Yoshimasa Ishimura, Hisashi Fujita, Shiro Takekawa

Bioorg Med Chem· February 2018

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Differential effects of selective agonists of neuromedin U1 and U2 receptors in obese and diabetic mice.
Hiroaki Nagai, Tomoko Kaisho, Kotaro Yokoyama, Tomoko Asakawa, Hisashi Fujita, Shiro Takekawa

Br J Pharmacol· January 2018

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Highly potent antiobesity effect of a short-length peptide YY analog in mice.
Naoki Nishizawa, Ayumu Niida, Yusuke Adachi, Yoko Kanematsu-Yamaki, Yasushi Masuda, Shiro Takekawa

Bioorg Med Chem· October 2017

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A potent neuromedin U receptor 2-selective alkylated peptide.
Naoki Nishizawa, Yoko Kanematsu-Yamaki, Masaaki Funata, Hiroaki Nagai, Ayako Shimizu, Shiro Takekawa

Bioorg Med Chem Lett· October 2017

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A potent and selective natriuretic peptide receptor-3 blocker 11-mer peptide created by hybridization of musclin and atrial natriuretic peptide.
Naoki Nishizawa, Goshi Nakamura, Yoko Noguchi, Hideyuki Nakagawa, Ayako Shimizu, Shiro Takekawa

Bioorg Med Chem Lett· August 2017

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Potent antiobesity effect of a short-length peptide YY-analogue continuously administered in mice.
Naoki Nishizawa, Ayumu Niida, Yusuke Adachi, Yasushi Masuda, Satoshi Kumano, Shiro Takekawa

Bioorg Med Chem Lett· August 2017

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Potent Body Weight-Lowering Effect of a Neuromedin U Receptor 2-selective PEGylated Peptide.
Yoko Kanematsu-Yamaki, Naoki Nishizawa, Tomoko Kaisho, Hiroaki Nagai, Taisuke Mochida, Shiro Takekawa

J Med Chem· July 2017

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A PEGylated analog of short-length Neuromedin U with potent anorectic and anti-obesity effects.
Hiroshi Inooka, Kotaro Sakamoto, Tokuyuki Shinohara, Yasushi Masuda, Michiko Terada, Shiro Takekawa

Bioorg Med Chem· April 2017

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A novel and selective melanin-concentrating hormone receptor 1 antagonist ameliorates obesity and hepatic steatosis in diet-induced obese rodent models.
Yayoi Kawata, Shoki Okuda, Natsu Hotta, Hideyuki Igawa, Masashi Takahashi, Shiro Takekawa

Eur J Pharmacol· February 2017

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Discovery of an artificial peptide agonist to the fibroblast growth factor receptor 1c/βKlotho complex from random peptide T7 phage display.
Kotaro Sakamoto, Yayoi Kawata, Yasushi Masuda, Tadashi Umemoto, Takashi Ito, Shiro Takekawa

Biochem Biophys Res Commun· November 2016

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Pharmacological Inhibition of Monoacylglycerol O-Acyltransferase 2 Improves Hyperlipidemia, Obesity, and Diabetes by Change in Intestinal Fat Utilization.
Kazumi Take, Taisuke Mochida, Toshiyuki Maki, Yoshinori Satomi, Megumi Hirayama, Shiro Takekawa

PLoS One· August 2016

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Optimization of a novel series of N-phenylindoline-5-sulfonamide-based acyl CoA:monoacylglycerol acyltransferase-2 inhibitors: Mitigation of CYP3A4 time-dependent inhibition and phototoxic liabilities.
Kenjiro Sato, Hiroki Takahagi, Osamu Kubo, Kousuke Hidaka, Takeshi Yoshikawa, Shiro Takekawa

Bioorg Med Chem· August 2015

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Discovery of a Novel Series of N-Phenylindoline-5-sulfonamide Derivatives as Potent, Selective, and Orally Bioavailable Acyl CoA:Monoacylglycerol Acyltransferase-2 Inhibitors.
Kenjiro Sato, Hiroki Takahagi, Takeshi Yoshikawa, Shinji Morimoto, Takafumi Takai, Shiro Takekawa

J Med Chem· May 2015

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Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors.
Yoshito Terao, Hideo Suzuki, Masato Yoshikawa, Hiroaki Yashiro, Shiro Takekawa

Bioorg Med Chem Lett· December 2012

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Synthesis, structure-activity relationship, and pharmacological studies of novel melanin-concentrating hormone receptor 1 antagonists 3-aminomethylquinolines: reducing human ether-a-go-go-related gene (hERG) associated liabilities.
Shizuo Kasai, Makoto Kamata, Shinichi Masada, Jun Kunitomo, Masahiro Kamaura, Shiro Takekawa

J Med Chem· May 2012

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Melanin-concentrating hormone receptor 1 antagonists. Synthesis and structure-activity relationships of novel 3-(aminomethyl)quinolines.
Makoto Kamata, Toshiro Yamashita, Toshihiro Imaeda, Toshio Tanaka, Shinichi Masada, Shiro Takekawa

J Med Chem· March 2012

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Melanin-concentrating hormone receptor 1 antagonists: synthesis, structure-activity relationship, docking studies, and biological evaluation of 2,3,4,5-tetrahydro-1H-3-benzazepine derivatives.
Shizuo Kasai, Masahiro Kamaura, Makoto Kamata, Kazuyoshi Aso, Hitomi Ogino, Shiro Takekawa

Bioorg Med Chem· November 2011

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Discovery, synthesis, and structure-activity relationship of 6-aminomethyl-7,8-dihydronaphthalenes as human melanin-concentrating hormone receptor 1 antagonists.
Makoto Kamata, Toshiro Yamashita, Toshihiro Imaeda, Toshio Tanaka, Jun Terauchi, Shiro Takekawa

Bioorg Med Chem· September 2011

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The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells.
Jonathan C Schisler, Per Bo Jensen, David G Taylor, Thomas C Becker, Filip Krag Knop, Shiro Takekawa

Proc Natl Acad Sci U S A· May 2005

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T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist.
Shiro Takekawa, Asano Asami, Yuji Ishihara, Jun Terauchi, Kaneyoshi Kato

Eur J Pharmacol· March 2002

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