Publications by authors named "Simon Knott"

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An immunological mechanism of resistance to CDK4/6 inhibitors in HR breast cancer.
Claudia Galassi, Giulia Petroni, Simon R V Knott, Lorenzo Galluzzi

Oncoimmunology· December 2025

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Lesion-remote astrocytes govern microglia-mediated white matter repair.
Sarah McCallum, Keshav B Suresh, Timothy S Islam, Manish K Tripathi, Ann W Saustad, Simon R V Knott

Nature· December 2025

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IL-17A-secreting γδ T cells promote resistance to CDK4/CDK6 inhibitors in HRHER2 breast cancer via CX3CR1 macrophages.
Giulia Petroni, Claudia Galassi, Kenneth H Gouin, Hsiang-Han Chen, Aitziber Buqué, Simon R V Knott

Nat Cancer· October 2025

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Author Correction: IL-17A-secreting γδ T cells promote resistance to CDK4/CDK6 inhibitors in HRHER2 breast cancer via CX3CR1 macrophages.
Giulia Petroni, Claudia Galassi, Kenneth H Gouin, Hsiang-Han Chen, Aitziber Buqué, Simon R V Knott

Nat Cancer· October 2025

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EZH2-TTP-mTORC1 Axis Drives Phenotypic Plasticity and Therapeutic Vulnerability in Lethal Prostate Cancer.
Beatriz German, Katherine L Morel, Teia Noel, Nadia Boufaied, Deborah L Burkhart, Simon R V Knott

bioRxiv· August 2025

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EZH2-TTP-mTORC1 Axis Drives Phenotypic Plasticity and Therapeutic Vulnerability in Lethal Prostate Cancer.
Beatriz German, Katherine L Morel, Teia Noel, Nadia Boufaied, Deborah L Burkhart, Simon R V Knott

Res Sq· August 2025

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Spatial transcriptomic analysis of immune checkpoint blockade response in triple negative breast cancers with tertiary lymphoid structures.
Richard H Mebane, Teia Noel, Nathan Ing, Kenneth H Gouin, Aagam Shah, Simon R V Knott

iScience· July 2025

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Concurrent loss of the Y chromosome in cancer and T cells impacts outcome.
Xingyu Chen, Yiling Shen, Suhyeon Choi, Hany A Abdel-Hafiz, Mukta Basu, Simon R V Knott

Nature· June 2025

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A macrophage-neutrophil program drives mammary carcinogenesis.
Lukas Bolini, Simon R V Knott, Lorenzo Galluzzi

Trends Cancer· May 2025

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Single-cell-guided identification of logic-gated antigen combinations for designing effective and safe CAR therapy.
Sanna Madan, Tian-Gen Chang, Alexandra R Harris, Huaitian Liu, Andrew Martinez, Simon R V Knott

bioRxiv· March 2025

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PEARL: A Phase Ib/II Biomarker Study of Adding Radiation Therapy to Pembrolizumab Before Neoadjuvant Chemotherapy in Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer.
Alice Y Ho, Stephen Shiao, Samantha A Kobald, Jonathan Chen, Dan G Duda, Simon Knott

J Clin Oncol· December 2024

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AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution.
Amy E Schade, Naiara Perurena, Yoona Yang, Carrie L Rodriguez, Anjana Krishnan, Simon R V Knott

Nature· November 2024

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Lesion-remote astrocytes govern microglia-mediated white matter repair.
Sarah McCallum, Keshav B Suresh, Timothy Islam, Ann W Saustad, Oksana Shelest, Simon R V Knott

bioRxiv· March 2024

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Single-cell and spatial profiling identify three response trajectories to pembrolizumab and radiation therapy in triple negative breast cancer.
Stephen L Shiao, Kenneth H Gouin, Nathan Ing, Alice Ho, Reva Basho, Simon R V Knott

Cancer Cell· January 2024

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MRI/RNA-Seq-Based Radiogenomics and Artificial Intelligence for More Accurate Staging of Muscle-Invasive Bladder Cancer.
Touseef Ahmad Qureshi, Xingyu Chen, Yibin Xie, Kaoru Murakami, Toru Sakatani, Simon R V Knott

Int J Mol Sci· December 2023

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Single-cell profiling of murine bladder cancer identifies sex-specific transcriptional signatures with prognostic relevance.
Hany A Abdel-Hafiz, Saravana Kumar Kailasam Mani, Wesley Huang, Kenneth H Gouin, Yuzhou Chang, Simon R V Knott

iScience· September 2023

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Updates on radiotherapy-immunotherapy combinations: Proceedings of 6 annual ImmunoRad conference.
Fabiana Gregucci, Sheila Spada, Mary Helen Barcellos-Hoff, Nina Bhardwaj, Charleen Chan Wah Hak, Simon R V Knott

Oncoimmunology· June 2023

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The molecular consequences of androgen activity in the human breast.
Florian Raths, Mehran Karimzadeh, Nathan Ing, Andrew Martinez, Yoona Yang, Simon R V Knott

Cell Genom· March 2023

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Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain.
Jinxiang Dai, Patrick J Cimino, Kenneth H Gouin, Candice A Grzelak, Alexander Barrett, Simon Knott

Nat Cancer· January 2022

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Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage.
Vera Chesnokova, Svetlana Zonis, Athanasia Apostolou, Hannah Q Estrada, Simon Knott

Cell Rep· December 2021

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TRIM28 is a transcriptional activator of the mutant TERT promoter in human bladder cancer.
Neeraj Agarwal, Sebastien Rinaldetti, Bassem B Cheikh, Qiong Zhou, Evan P Hass, Simon R V Knott

Proc Natl Acad Sci U S A· September 2021

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An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer.
Kenneth H Gouin, Nathan Ing, Jasmine T Plummer, Charles J Rosser, Bassem Ben Cheikh, Simon R V Knott

Nat Commun· August 2021

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Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth.
Abigail S Krall, Peter J Mullen, Felicia Surjono, Milica Momcilovic, Ernst W Schmid, Simon R V Knott

Cell Metab· May 2021

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Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans.
Connie W Y Ha, Anthony Martin, Gregory D Sepich-Poore, Baochen Shi, Yizhou Wang, Simon Knott

Cell· October 2020

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Characterization of universal features of partially methylated domains across tissues and species.
Benjamin E Decato, Jianghan Qu, Xiaojing Ji, Elvin Wagenblast, Simon R V Knott

Epigenetics Chromatin· October 2020

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