Publications by authors named "Simon P MacKay"

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IL-1β stimulates a novel axis within the NFκB pathway in endothelial cells regulated by IKKα and TAK-1.
Rachel Craig, Kathryn McIntosh, Ka Ho Ho, Ashley McCulloch, Christopher Riley, Simon P Mackay

Biochem Pharmacol· February 2025

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Design and Synthesis of Novel Aminoindazole-pyrrolo[2,3-]pyridine Inhibitors of IKKα That Selectively Perturb Cellular Non-Canonical NF-κB Signalling.
Christopher Riley, Usama Ammar, Aisha Alsfouk, Nahoum G Anthony, Jessica Baiget, Simon P Mackay

Molecules· July 2024

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Targeting the Non-Canonical NF-κB Pathway in Chronic Lymphocytic Leukemia and Multiple Myeloma.
Thomas A Burley, Emma Kennedy, Georgia Broad, Melanie Boyd, David Li, Simon P Mackay

Cancers (Basel)· March 2022

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Mitokyne: A Ratiometric Raman Probe for Mitochondrial pH.
Liam T Wilson, William J Tipping, Corinna Wetherill, Zoë Henley, Karen Faulds, Simon P Mackay

Anal Chem· September 2021

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Determining the prognostic significance of IKKα in prostate cancer.
Melania Montes, Lewis MacKenzie, Milly J McAllister, Antonia Roseweir, Pamela McCall, Simon P MacKay

Prostate· October 2020

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A new class of ratiometric small molecule intracellular pH sensors for Raman microscopy.
Liam T Wilson, William J Tipping, Lauren E Jamieson, Corinna Wetherill, Zoë Henley, Simon P Mackay

Analyst· August 2020

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Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes.
Rose-Laure Indorato, Sandeep K Talapatra, Fangzhu Lin, Shozeb Haider, Simon P Mackay

Mol Cancer Ther· December 2019

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Topographical Mapping of Isoform-Selectivity Determinants for J-Channel-Binding Inhibitors of Sphingosine Kinases 1 and 2.
David R Adams, Salha Tawati, Giacomo Berretta, Paula Lopez Rivas, Jessica Baiget, Simon P Mackay

J Med Chem· April 2019

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Synthetic biological approaches for RNA labelling and imaging: design principles and future opportunities.
Steven Pauff, Jamie M Withers, Iain Jw McKean, Simon P Mackay, Glenn A Burley

Curr Opin Biotechnol· December 2017

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Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers.
Nahoum G Anthony, Jessica Baiget, Giacomo Berretta, Marie Boyd, David Breen, Simon P Mackay

J Med Chem· August 2017

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Pyrrole-Imidazole Polyamides: Manual Solid-Phase Synthesis.
Steven M Pauff, Andrew J Fallows, Simon P Mackay, Wu Su, Paul M Cullis

Curr Protoc Nucleic Acid Chem· December 2015

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Resveratrol and its oligomers: modulation of sphingolipid metabolism and signaling in disease.
Keng Gat Lim, Alexander I Gray, Nahoum G Anthony, Simon P Mackay, Susan Pyne

Arch Toxicol· December 2014

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Recognition of the DNA minor groove by thiazotropsin analogues.
Hasan Y Alniss, Marie-Virginie Salvia, Mykhailo Sadikov, Igor Golovchenko, Nahoum G Anthony, Simon P MacKay

Chembiochem· September 2014

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Stereoselective synthesis of carbocyclic analogues of the nucleoside Q precursor (PreQ0).
Sabin Llona-Minguez, Simon P Mackay

Beilstein J Org Chem· July 2014

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Structure-activity relationships and molecular modeling of sphingosine kinase inhibitors.
Dong Jae Baek, Neil MacRitchie, Nahoum G Anthony, Simon P Mackay, Susan Pyne

J Med Chem· November 2013

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Thiazotropsin aggregation and its relationship to molecular recognition in the DNA minor groove.
Marie-Virginie Salvia, Fiona Addison, Hasan Y Alniss, Niklaas J Buurma, Abedawn I Khalaf, Simon P Mackay

Biophys Chem· September 2013

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Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells.
Jolanta Wiejak, Julia Dunlop, Simon P Mackay, Stephen J Yarwood

Biochem J· September 2013

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Mitotic kinesin Eg5 overcomes inhibition to the phase I/II clinical candidate SB743921 by an allosteric resistance mechanism.
Sandeep K Talapatra, Nahoum G Anthony, Simon P Mackay, Frank Kozielski

J Med Chem· August 2013

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Small-molecule inhibitors of IκB kinase (IKK) and IKK-related kinases.
Sabin Llona-Minguez, Jessica Baiget, Simon P Mackay

Pharm Pat Anal· July 2013

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Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.
James A D Good, Fang Wang, Oliver Rath, Hung Yi Kristal Kaan, Sandeep K Talapatra, Simon P MacKay

J Med Chem· March 2013

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Confined compression of collagen hydrogels.
Grahame A Busby, M Helen Grant, Simon P Mackay, Philip E Riches

J Biomech· February 2013

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Design and synthesis of EGFR dimerization inhibitors and evaluation of their potential in the treatment of psoriasis.
Donna Petch, Rosaleen J Anderson, Anne Cunningham, Suja E George, David E Hibbs, Simon P Mackay

Bioorg Med Chem· October 2012

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Identification and development of the 1,4-benzodiazepin-2-one and quinazoline-2,4-dione scaffolds as submicromolar inhibitors of HAT.
Rachel L Clark, Carol J Clements, Michael P Barrett, Simon P Mackay, Rajendra P Rathnam

Bioorg Med Chem· October 2012

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Doing the methylene shuffle--further insights into the inhibition of mitotic kinesin Eg5 with S-trityl L-cysteine.
Murad N Abualhasan, James A D Good, Kitiyaporn Wittayanarakul, Nahoum G Anthony, Giacomo Berretta, Simon P Mackay

Eur J Med Chem· August 2012

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Triphenylbutanamines: kinesin spindle protein inhibitors with in vivo antitumor activity.
Fang Wang, James A D Good, Oliver Rath, Hung Yi Kristal Kaan, Oliver B Sutcliffe, Simon P Mackay

J Med Chem· February 2012

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