Publications by authors named "Stephanie Moquin"

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Structural Analysis of Inhibitor Binding to the Feline Enteric Coronavirus (FECV) Main Protease.
Arooma Maryam, Stephanie A Moquin, Dustin Dovala, Jagroop Kaur, Nese Kurt Yilmaz

Viruses· November 2025

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Cooperativity and Communication between the Active Sites of the Dimeric SARS-CoV-2 Main Protease.
Sarah N Zvornicanin, Ala M Shaqra, Julia Flynn, Lauren E Intravaia, Heidi Carias Martinez, Stephanie Moquin

bioRxiv· July 2025

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Molecular mechanisms of drug resistance and compensation in SARS-CoV-2 main protease: the interplay between E166 and L50.
Sarah N Zvornicanin, Ala M Shaqra, Julia Flynn, Heidi Carias Martinez, Weiping Jia, Stephanie Moquin

mBio· May 2025

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Mechanistic insights into dengue virus inhibition by a clinical trial compound NITD-688.
Yan Wang, Long Sun, Luciana Fernandes, Yu-Hsiu Wang, Jing Zou, Stephanie A Moquin

Proc Natl Acad Sci U S A· April 2025

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Rapid-response RNA-fluorescence in situ hybridization (FISH) assay platform for coronavirus antiviral high-throughput screening.
Ryan Chan, Christian Shema Mugisha, Vorada Chuenchob, Stephanie A Moquin, Ujjini H Manjunatha

SLAS Discov· December 2024

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Identification of Potent, Broad-Spectrum Coronavirus Main Protease Inhibitors for Pandemic Preparedness.
David T Barkan, Keira Garland, Lei Zhang, Richard T Eastman, Matthew Hesse, Stephanie Moquin

J Med Chem· October 2024

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Contributions of Hyperactive Mutations in M from SARS-CoV-2 to Drug Resistance.
Julia M Flynn, Sarah N Zvornicanin, Tenzin Tsepal, Ala M Shaqra, Nese Kurt Yilmaz, Stephanie Moquin

ACS Infect Dis· April 2024

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Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease.
Julia M Flynn, Qiu Yu J Huang, Sarah N Zvornicanin, Gila Schneider-Nachum, Ala M Shaqra, Stephanie A Moquin

ACS Infect Dis· July 2023

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Discovery of Potent Pyrazoline-Based Covalent SARS-CoV-2 Main Protease Inhibitors.
Patrick Moon, Charlotte M Zammit, Qian Shao, Dustin Dovala, Lydia Boike, Stephanie A Moquin

Chembiochem· June 2023

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Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses.
Sarah N Zvornicanin, Ala M Shaqra, Qiuyu J Huang, Elizabeth Ornelas, Mallika Moghe, Stephanie Moquin

Viruses· March 2023

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Comprehensive fitness landscape of SARS-CoV-2 M reveals insights into viral resistance mechanisms.
Julia M Flynn, Neha Samant, Gily Schneider-Nachum, David T Barkan, Nese Kurt Yilmaz, Stephanie A Moquin

Elife· June 2022

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Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance.
Ala M Shaqra, Sarah N Zvornicanin, Qiu Yu J Huang, Gordon J Lockbaum, Mark Knapp, Stephanie Moquin

Nat Commun· June 2022

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NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models.
Stephanie A Moquin, Oliver Simon, Ratna Karuna, Suresh B Lakshminarayana, Fumiaki Yokokawa

Sci Transl Med· February 2021

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The Epstein-Barr Virus Episome Maneuvers between Nuclear Chromatin Compartments during Reactivation.
Stephanie A Moquin, Sean Thomas, Sean Whalen, Alix Warburton, Samantha G Fernandez

J Virol· February 2018

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Bromodomain and extraterminal inhibitors block the Epstein-Barr virus lytic cycle at two distinct steps.
Kristin M Keck, Stephanie A Moquin, Amanda He, Samantha G Fernandez, Jessica J Somberg

J Biol Chem· August 2017

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PARP1 restricts Epstein Barr Virus lytic reactivation by binding the BZLF1 promoter.
Lena N Lupey-Green, Stephanie A Moquin, Kayla A Martin, Shane M McDevitt, Michael Hulse

Virology· July 2017

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Somatic Hypermutation-Induced Changes in the Structure and Dynamics of HIV-1 Broadly Neutralizing Antibodies.
Thaddeus M Davenport, Jason Gorman, M Gordon Joyce, Tongqing Zhou, Cinque Soto, Stephanie Moquin

Structure· August 2016

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Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Tongqing Zhou, Rebecca M Lynch, Lei Chen, Priyamvada Acharya, Xueling Wu, Stephanie Moquin

Cell· June 2015

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Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies.
Tongqing Zhou, Jiang Zhu, Xueling Wu, Stephanie Moquin, Baoshan Zhang

Immunity· August 2013

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Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization.
Ivelin S Georgiev, Nicole A Doria-Rose, Tongqing Zhou, Young Do Kwon, Ryan P Staupe, Stephanie Moquin

Science· May 2013

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Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.
Hua-Xin Liao, Rebecca Lynch, Tongqing Zhou, Feng Gao, S Munir Alam, Stephanie Moquin

Nature· April 2013

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Outer domain of HIV-1 gp120: antigenic optimization, structural malleability, and crystal structure with antibody VRC-PG04.
M Gordon Joyce, Masaru Kanekiyo, Ling Xu, Christian Biertümpfel, Jeffrey C Boyington, Stephanie Moquin

J Virol· February 2013

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PGV04, an HIV-1 gp120 CD4 binding site antibody, is broad and potent in neutralization but does not induce conformational changes characteristic of CD4.
Emilia Falkowska, Alejandra Ramos, Yu Feng, Tongqing Zhou, Stephanie Moquin

J Virol· April 2012

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Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.
Jason S McLellan, Marie Pancera, Chris Carrico, Jason Gorman, Jean-Philippe Julien, Stephanie Moquin

Nature· November 2011

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