Publications by authors named "Stephen Betz"

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Continuous Glucose Monitoring-Derived Glycemic Phenotyping of Childhood Hypoglycemia Due to Hyperinsulinism: A Year-long Prospective Nationwide Observational Study.
Chris Worth, Sameera Auckburally, Sarah Worthington, Sumera Ahmad, Elaine O'Shea, Stephen Betz

J Diabetes Sci Technol· November 2025

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Discovery of CRN04894: A Novel Potent Selective MC2R Antagonist.
Sun Hee Kim, Sangdon Han, Jian Zhao, Shimiao Wang, Ana Karin Kusnetzow, Stephen F Betz

ACS Med Chem Lett· April 2024

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A selective nonpeptide somatostatin receptor 5 agonist effectively decreases insulin secretion in hyperinsulinism.
Christine A Juliana, Jinghua Chai, Pablo Arroyo, Elizabeth Rico-Bautista, Stephen F Betz

J Biol Chem· June 2023

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Discovery of Paltusotine (CRN00808), a Potent, Selective, and Orally Bioavailable Non-peptide SST2 Agonist.
Jian Zhao, Shimiao Wang, Stacy Markison, Sun Hee Kim, Sangdon Han, Stephen F Betz

ACS Med Chem Lett· January 2023

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Somatostatin receptors in congenital hyperinsulinism: Biology to bedside.
Mirjam E van Albada, Klaus Mohnike, Mark J Dunne, Indi Banerjee, Stephen F Betz

Front Endocrinol (Lausanne)· October 2022

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Discovery of 4-(3-aminopyrrolidinyl)-3-aryl-5-(benzimidazol-2-yl)-pyridines as potent and selective SST5 agonists for the treatment of congenital hyperinsulinism.
Jian Zhao, Shimiao Wang, Sun Hee Kim, Sangdon Han, Elizabeth Rico-Bautista, Stephen F Betz

Bioorg Med Chem Lett· September 2022

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Paltusotine, a novel oral once-daily nonpeptide SST2 receptor agonist, suppresses GH and IGF-1 in healthy volunteers.
Ajay Madan, Stacy Markison, Stephen F Betz, Alan Krasner, Rosa Luo

Pituitary· April 2022

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Discovery of substituted 3H-pyrido[2,3-d]pyrimidin-4-ones as potent, biased, and orally bioavailable sst2 agonist.
Jian Zhao, Zhiyong Chen, Ana Karin Kusnetzow, Julie Nguyen, Elizabeth Rico-Bautista, Stephen F Betz

Bioorg Med Chem Lett· November 2020

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Discovery of nonpeptide 3,4-dihydroquinazoline-4-carboxamides as potent and selective sst2 agonists.
Jian Zhao, Shimiao Wang, Sangdon Han, Sun Hee Kim, Ana Karin Kusnetzow, Stephen F Betz

Bioorg Med Chem Lett· September 2020

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Non-peptide gonadotropin-releasing hormone receptor antagonists.
Stephen F Betz, Yun-Fei Zhu, Chen Chen, R Scott Struthers

J Med Chem· June 2008

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Identification of 2-(4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-ethylamine derivatives as novel GnRH receptor antagonists.
Mi Chen, Zhiqiang Guo, Marion C Lanier, Liren Zhao, Stephen F Betz

Bioorg Med Chem Lett· July 2007

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Design and characterization of an engineered gp41 protein from human immunodeficiency virus-1 as a tool for drug discovery.
Kent D Stewart, Kevin Steffy, Kevin Harris, John E Harlan, Vincent S Stoll, Stephen F Betz

J Comput Aided Mol Des· May 2007

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Allosteric and orthosteric binding modes of two nonpeptide human gonadotropin-releasing hormone receptor antagonists.
Susan K Sullivan, Michael S Brown, Yinghong Gao, Colin J Loweth, Francisco M Lio, Stephen F Betz

Biochemistry· December 2006

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Determination of the binding mode of thienopyrimidinedione antagonists to the human gonadotropin releasing hormone receptor using structure-activity relationships, site-directed mutagenesis, and homology modeling.
Stephen F Betz, Francisco M Lio, Yinghong Gao, Greg J Reinhart, Zhiqiang Guo

J Med Chem· October 2006

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Single amino acid residue determinants of non-peptide antagonist binding to the corticotropin-releasing factor1 (CRF1) receptor.
Sam R J Hoare, Brock T Brown, Mark A Santos, Siobhan Malany, Stephen F Betz

Biochem Pharmacol· July 2006

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Overlapping, nonidentical binding sites of different classes of nonpeptide antagonists for the human gonadotropin-releasing hormone receptor.
Stephen F Betz, Greg J Reinhart, Francisco M Lio, Chen Chen, R Scott Struthers

J Med Chem· January 2006

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Non-peptidic small molecule inhibitors of XIAP.
Cheol-Min Park, Chaohong Sun, Edward T Olejniczak, Alan E Wilson, Robert P Meadows, Stephen F Betz

Bioorg Med Chem Lett· February 2005

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The crystal structure of a quercetin 2,3-dioxygenase from Bacillus subtilis suggests modulation of enzyme activity by a change in the metal ion at the active site(s).
B Gopal, Lalima L Madan, Stephen F Betz, Anthony A Kossiakoff

Biochemistry· January 2005

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Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
Thorsten K Oost, Chaohong Sun, Robert C Armstrong, Ali-Samer Al-Assaad, Stephen F Betz

J Med Chem· August 2004

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Discovery of potent inhibitors of dihydroneopterin aldolase using CrystaLEAD high-throughput X-ray crystallographic screening and structure-directed lead optimization.
William J Sanders, Vicki L Nienaber, Claude G Lerner, J Owen McCall, Sean M Merrick, Stephen F Betz

J Med Chem· March 2004

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1H, 13C and 15N resonance assignments and secondary structure of the human protein tyrosine phosphatase, PRL-2.
Hongjun Zhou, Marijo Gallina, Hongyuan Mao, Daniel Nietlispach, Stephen F Betz

J Biomol NMR· December 2003

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A strategy for high-throughput assay development using leads derived from nuclear magnetic resonance-based screening.
Philip J Hajduk, Stephen F Betz, Jamey Mack, Xiaoan Ruan, Danli L Towne

J Biomol Screen· October 2002

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Function first: a powerful approach to post-genomic drug discovery.
Stephen F Betz, Susan M Baxter, Jacquelyn S Fetrow

Drug Discov Today· August 2002

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