Publications by authors named "Steve Price"

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Creating reasonable antibiograms for antibiotic stewardship programs in nursing homes: Analysis of 260 facilities in a large geographic region, 2016-2017.
Scott K Fridkin, Jacob Pack, Giancarlo Licitra, Ziduo Zheng, Russell Watkins, Steve Price

Infect Control Hosp Epidemiol· August 2019

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The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).
Timothy P Heffron, Robert A Heald, Chudi Ndubaku, BinQing Wei, Martin Augistin, Steve Price

J Med Chem· February 2016

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Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479.
Kirk D Robarge, Wendy Lee, Charles Eigenbrot, Mark Ultsch, Christian Wiesmann, Steve Price

Bioorg Med Chem Lett· October 2014

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Identification of GNE-293, a potent and selective PI3Kδ inhibitor: navigating in vitro genotoxicity while improving potency and selectivity.
Brian S Safina, Zachary K Sweeney, Jun Li, Bryan K Chan, Angelina Bisconte, Steve Price

Bioorg Med Chem Lett· September 2013

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Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers.
Georgia Hatzivassiliou, Jacob R Haling, Huifen Chen, Kyung Song, Steve Price

Nature· September 2013

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Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity.
Chudi O Ndubaku, Timothy P Heffron, Steven T Staben, Matthew Baumgardner, Nicole Blaquiere, Steve Price

J Med Chem· June 2013

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Potent and selective inhibitors of PI3Kδ: obtaining isoform selectivity from the affinity pocket and tryptophan shelf.
Daniel P Sutherlin, Stewart Baker, Angelina Bisconte, Paul M Blaney, Anthony Brown, Steve Price

Bioorg Med Chem Lett· July 2012

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Discovery of novel PI3-kinase δ specific inhibitors for the treatment of rheumatoid arthritis: taming CYP3A4 time-dependent inhibition.
Brian S Safina, Stewart Baker, Matt Baumgardner, Paul M Blaney, Bryan K Chan, Steve Price

J Med Chem· June 2012

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Discovery of novel allosteric mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors possessing bidentate Ser212 interactions.
Robert A Heald, Philip Jackson, Pascal Savy, Mark Jones, Emanuela Gancia, Steve Price

J Med Chem· May 2012

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Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists.
Sue Cramp, Hazel J Dyke, Christopher Higgs, David E Clark, Matthew Gill, Steve Price

Bioorg Med Chem Lett· April 2010

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Increasing selectivity of CC chemokine receptor 8 antagonists by engineering nondesolvation related interactions with the intended and off-target binding sites.
Igor Shamovsky, Chris de Graaf, Lisa Alderin, Malena Bengtsson, Håkan Bladh, Steve Price

J Med Chem· December 2009

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Relationship between physical activity and type of smoking behavior among adolescents and young adults in Cyprus.
Marianna Charilaou, Maria Karekla, Marios Constantinou, Steve Price

Nicotine Tob Res· August 2009

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Identification and optimisation of a series of substituted 5-(1H-pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.
Steve Price, Walter Bordogna, Richard J Bull, David E Clark, Peter H Crackett

Bioorg Med Chem Lett· January 2007

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Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.
Steve Price, Walter Bordogna, Ruth Braganza, Richard J Bull, Hazel J Dyke

Bioorg Med Chem Lett· January 2007

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Solid-phase synthesis of N-formylhydroxylamines (reverse/retro-hydroxamates).
Steve Price, Susan E Osbourn

Org Lett· August 2005

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