Publications by authors named "Steven Coffey"

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6
6-Azaspiro[2.5]octanes as small molecule agonists of the human glucagon-like peptide-1 receptor.
Gary E Aspnes, Scott W Bagley, Steven B Coffey, Edward L Conn, John M Curto

Bioorg Med Chem Lett· October 2023

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Decarboxylative Cross-Electrophile Coupling of (Hetero)Aromatic Bromides and NHP Esters.
Ethan M DeCicco, Simon Berritt, Thomas Knauber, Steven B Coffey, Jie Hou

J Org Chem· September 2023

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Small molecule inhibitors of PCSK9. SAR investigations of head and amine groups.
Gary E Aspnes, Steven B Coffey, Etzer Darout, Anne-Marie Dechert-Schmitt, Robert G Dullea

Bioorg Med Chem Lett· August 2023

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Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.
Allyn T Londregan, Karlygash Aitmakhanova, James Bennett, Laura J Byrnes, Daniel P Canterbury, Steven B Coffey

J Med Chem· January 2023

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Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis.
Kentaro Futatsugi, Shawn Cabral, Daniel W Kung, Kim Huard, Esther Lee, Steven B Coffey

J Med Chem· November 2022

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Discovery and evaluation of non-basic small molecule modulators of the atypical chemokine receptor CXCR7.
Gary E Aspnes, Elnaz Menhaji-Klotz, Markus Boehm, Allyn T Londregan, Esther C Y Lee, Steven B Coffey

Bioorg Med Chem Lett· October 2021

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Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.
Kentaro Futatsugi, Aaron C Smith, Meihua Tu, Brian Raymer, Kay Ahn, Steven B Coffey

J Med Chem· November 2020

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Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs.
Hao Sun, David W Piotrowski, Suvi T M Orr, Joseph S Warmus, Angela C Wolford, Steven B Coffey

PLoS One· April 2019

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Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents.
Allyn T Londregan, Liuqing Wei, Jun Xiao, Nathanael G Lintner, Donna Petersen, Steven B Coffey

J Med Chem· July 2018

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Identification of Morpholino-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-ones as Nonsteroidal Mineralocorticoid Antagonists.
David W Piotrowski, Kentaro Futatsugi, Agustin Casimiro-Garcia, Liuqing Wei, Matthew F Sammons, Steven B Coffey

J Med Chem· February 2018

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Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).
Kim Huard, Kay Ahn, Paul Amor, David A Beebe, Kris A Borzilleri, Steven B Coffey

J Med Chem· September 2017

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Reaction of Alkyl Halides with Rongalite: One-Pot and Telescoped Syntheses of Aliphatic Sulfonamides, Sulfonyl Fluorides, and Unsymmetrical Sulfones.
Andre Shavnya, Steven B Coffey, Kevin D Hesp, Stuart C Ross, Andy S Tsai

Org Lett· November 2016

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Optimization of amide-based EP3 receptor antagonists.
Esther C Y Lee, Kentaro Futatsugi, Joel T Arcari, Kevin Bahnck, Steven B Coffey

Bioorg Med Chem Lett· June 2016

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Preparation of Heteroaryl Ethers from Azine N-Oxides and Alcohols.
Yajing Lian, Steven B Coffey, Qifang Li, Allyn T Londregan

Org Lett· March 2016

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Expedient Synthesis of N1-Substituted Triazole Peptidomimetics.
Steven B Coffey, Gary Aspnes, Allyn T Londregan

ACS Comb Sci· December 2015

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Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3.
Kim Huard, Allyn T Londregan, Gregory Tesz, Kevin B Bahnck, Thomas V Magee, Steven B Coffey

J Med Chem· September 2015

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Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2).
Kentaro Futatsugi, Daniel W Kung, Suvi T M Orr, Shawn Cabral, David Hepworth, Steven B Coffey

J Med Chem· September 2015

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Evaluation and synthesis of polar aryl- and heteroaryl spiroazetidine-piperidine acetamides as ghrelin inverse agonists.
Suvi T M Orr, Ramsay Beveridge, Samit K Bhattacharya, Kimberly O Cameron, Steven Coffey

ACS Med Chem Lett· February 2015

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Palladium-catalyzed sulfination of aryl and heteroaryl halides: direct access to sulfones and sulfonamides.
Andrei Shavnya, Steven B Coffey, Aaron C Smith, Vincent Mascitti

Org Lett· December 2013

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Identification of Tetrahydropyrido[4,3-d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists.
David W Piotrowski, Kentaro Futatsugi, Joseph S Warmus, Suvi T M Orr, Kevin D Freeman-Cook, Steven B Coffey

ACS Med Chem Lett· January 2013

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Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor.
Daniel W Kung, Steven B Coffey, Ryan M Jones, Shawn Cabral, Wenhua Jiao

Bioorg Med Chem Lett· July 2012

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Maximizing lipophilic efficiency: the use of Free-Wilson analysis in the design of inhibitors of acetyl-CoA carboxylase.
Kevin D Freeman-Cook, Paul Amor, Scott Bader, Leanne M Buzon, Steven B Coffey

J Med Chem· January 2012

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Orally active and brain permeable proline amides as highly selective 5HT2c agonists for the treatment of obesity.
Kevin K-C Liu, Bruce A Lefker, Mark A Dombroski, Phoebe Chiang, Peter Cornelius, Steven B Coffey

Bioorg Med Chem Lett· April 2010

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Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2.
Jeffrey W Corbett, Kevin D Freeman-Cook, Richard Elliott, Felix Vajdos, Francis Rajamohan, Steven B Coffey

Bioorg Med Chem Lett· April 2010

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