Publications by authors named "Steven Kleinstein"

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Evaluating COVID-19 severity prediction and immune dynamics with NULISAseq: Insights from the IMPACC study.
Koji Abe, Tyson H Holmes, Tran T Nguyen, , Seunghee Kim-Schulze, Steven H Kleinstein

J Immunol· December 2025

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Sequential class switching generates antigen-specific gut IgA from IgG1 B cells.
Emily R Siniscalco, Hailong Meng, Gisela Gabernet, Gaspar A Pacheco, Shahab Saghaei, Steven H Kleinstein

Immunity· December 2025

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MTHFR allele and one-carbon metabolic profile predict severity of COVID-19.
Boryana Petrova, Caitlin Syphurs, Andrew J Culhane, Jing Chen, Ernie Chen, Steven H Kleinstein

Proc Natl Acad Sci U S A· December 2025

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A multiomics recovery factor predicts long COVID in the IMPACC study.
Gisela Gabernet, Jessica Maciuch, Jeremy P Gygi, John F Moore, Annmarie Hoch, Steven H Kleinstein

J Clin Invest· November 2025

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Minimalistic transcriptomic signatures permit accurate early prediction of COVID-19 mortality.
Rithwik Narendra, Emily C Lydon, Hoang Van Phan, Natasha Spottiswoode, Lucile P Neyton, Steven H Kleinstein

JCI Insight· November 2025

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Innate immune molecular landscape following controlled human influenza virus infection.
William Thistlethwaite, Sindhu Vangeti, Wan-Sze Cheng, Pankaj Agarwal, Antonio Cappuccio, Steven H Kleinstein

Cell Rep· October 2025

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Circulating endothelial signatures correlate with worse outcomes in COVID-19, respiratory failure and ARDS.
Ana C Costa Monteiro, Harry Pickering, Aartik Sarma, Clove S Taylor, Meagan M Jenkins, Steven H Kleinstein

Crit Care· October 2025

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Mapping of human monoclonal antibody responses to XBB.1.5 COVID-19 monovalent vaccines: a B cell analysis.
Raianna F Fantin, Jordan J Clark, Hallie Cohn, Deepika Jaiswal, Bailey Bozarth, Steven H Kleinstein

Lancet Microbe· August 2025

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MICBG406A polymorphism reduces risk of mechanical ventilation and death during viral acute lung injury.
Harry Pickering, Narges Alipanah-Lechner, Ernie Chen, Dylan Duchen, Holden T Maecker, Steven H Kleinstein

JCI Insight· August 2025

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High-affinity CD16A polymorphism associated with reduced risk ofsevere COVID-19.
Anita E Qualls, Tasha Tsao, Irene Lui, Shion A Lim, Yapeng Su, Steven H Kleinstein

JCI Insight· July 2025

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BLIMP1 controls GC B cell expansion and exit through regulating cell cycle progression and key transcription factors BCL6 and IRF4.
Laura Conter, Shuchi Smita, Derrick Callahan, Shuxian Wu, Aiden Brown, Steven H Kleinstein

Cell Rep· July 2025

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Baseline predictors for 28-day COVID-19 severity and mortality among hospitalized patients: results from the IMPACC study.
Jintong Hou, Benjamin Haslund-Gourley, Joann Diray-Arce, Annmarie Hoch, Nadine Rouphael, Steven H Kleinstein

Front Med (Lausanne)· July 2025

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Germline-encoded recognition of peanut underlies development of convergent antibodies in humans.
Orlee Marini-Rapoport, Léna Andrieux, Tarun Keswani, Guangning Zong, Dylan Duchen, Steven H Kleinstein

Sci Transl Med· June 2025

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Empiric Azithromycin in COVID-19 Impacts the Respiratory Microbiome and Antimicrobial Resistome without Anti-inflammatory Benefit.
Charles Langelier, Abigail Glascock, Cole Maguire, Hoang Van Phan, Emily Lydon, Steven Kleinstein

Res Sq· June 2025

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Single cell immunophenotyping identifies CD8 GZMK IFNG T cells as a key immune population in cutaneous Lyme disease.
Edel Aron, Hailong Meng, Paraskevas Filippidis, Alexia A Belperron, Steven H Kleinstein

bioRxiv· June 2025

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Minimalistic Transcriptomic Signatures Permit Accurate Early Prediction of COVID-19 Mortality.
Rithwik Narendra, Emily C Lydon, Hoang Van Phan, Natasha Spottiswoode, Lucile P Neyton, Steven H Kleinstein

medRxiv· May 2025

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Partially characterized topology guides reliable anchor-free scRNA-integration.
Chuan He, Paraskevas Filippidis, Steven H Kleinstein, Leying Guan

Commun Biol· April 2025

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A single-cell atlas of circulating immune cells over the first 2 months of age in extremely premature infants.
Oluwabunmi Olaloye, Weihong Gu, Arne Gehlhaar, Burhanuddin Sabuwala, Chino K Eke, Steven H Kleinstein

Sci Transl Med· March 2025

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An Allele of the MTHFR one-carbon metabolism gene predicts severity of COVID-19.
Boryana Petrova, Caitlin Syphurs, Andrew J Culhane, Jing Chen, Ernie Chen, Steven Kleinstein

medRxiv· March 2025

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Supervised fine-tuning of pre-trained antibody language models improves antigen specificity prediction.
Meng Wang, Jonathan Patsenker, Henry Li, Yuval Kluger, Steven H Kleinstein

PLoS Comput Biol· March 2025

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Putting computational models of immunity to the test-An invited challenge to predict B.pertussis vaccination responses.
Pramod Shinde, Lisa Willemsen, Michael Anderson, Minori Aoki, Saonli Basu, Steven H Kleinstein

PLoS Comput Biol· March 2025

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AMULETY: A Python package to embed adaptive immune receptor sequences.
Meng Wang, Yuval Kluger, Steven H Kleinstein, Gisela Gabernet

bioRxiv· March 2025

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Identification of a multi-omics factor predictive of long COVID in the IMPACC study.
Gisela Gabernet, Jessica Maciuch, Jeremy P Gygi, John F Moore, Annmarie Hoch, Steven H Kleinstein

bioRxiv· February 2025

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Machine learning models predict long COVID outcomes based on baseline clinical and immunologic factors.
Naresh Doni Jayavelu, Hady Samaha, Sonia Tandon Wimalasena, Annmarie Hoch, Jeremy P Gygi, Steven H Kleinstein

medRxiv· February 2025

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nipalsMCIA: flexible multi-block dimensionality reduction in R via nonlinear iterative partial least squares.
Max Mattessich, Joaquin Reyna, Edel Aron, Ferhat Ay, Misha Kilmer, Steven H Kleinstein

Bioinformatics· December 2024

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