Publications by authors named "Steven Langston"

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A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo.
Stanley C Xie, Chia-Wei Tai, Craig J Morton, Liting Ma, Shih-Chung Huang, Steven Langston

PLoS Pathog· December 2024

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Investigation of the enhanced antitumour potency of STING agonist after conjugation to polymer nanoparticles.
Pere Dosta, Alexander M Cryer, Michelle Z Dion, Tsubasa Shiraishi, Steven P Langston

Nat Nanotechnol· November 2023

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Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.
Stanley C Xie, Riley D Metcalfe, Elyse Dunn, Craig J Morton, Shih-Chung Huang, Steven P Langston

Science· June 2022

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Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route.
Stepan Vyskocil, David Cardin, Jeffrey Ciavarri, Joe Conlon, Courtney Cullis, Steven P Langston

J Med Chem· May 2021

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Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer.
Steven P Langston, Stephen Grossman, Dylan England, Roushan Afroze, Neil Bence

J Med Chem· March 2021

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Optimization of tetrahydronaphthalene inhibitors of Raf with selectivity over hERG.
Shih-Chung Huang, Sharmila Adhikari, Roushan Afroze, Katherine Brewer, Emily F Calderwood, Steven P Langston

Bioorg Med Chem Lett· February 2016

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Design and optimization of potent and orally bioavailable tetrahydronaphthalene Raf inhibitors.
Alexandra E Gould, Ruth Adams, Sharmila Adhikari, Kathleen Aertgeerts, Roushan Afroze, Steven P Langston

J Med Chem· March 2011

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MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma.
Michael A Milhollen, Tary Traore, Jennifer Adams-Duffy, Michael P Thomas, Allison J Berger, Steven P Langston

Blood· September 2010

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Discovery and optimization of pyrazoline compounds as B-Raf inhibitors.
Matthew O Duffey, Ruth Adams, Christopher Blackburn, Ryan W Chau, Susan Chen, Steven Langston

Bioorg Med Chem Lett· August 2010

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Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ.
James E Brownell, Michael D Sintchak, James M Gavin, Hua Liao, Frank J Bruzzese, Steven P Langston

Mol Cell· January 2010

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An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer.
Teresa A Soucy, Peter G Smith, Michael A Milhollen, Allison J Berger, James M Gavin, Steven P Langston

Nature· April 2009

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Preparation of kinase-biased compounds in the search for lead inhibitors of kinase targets.
Justine Y Q Lai, Steven Langston, Ruth Adams, Rebekah E Beevers, Richard Boyce

Med Res Rev· May 2005

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Enzymatic characterization of the pancreatic islet-specific glucose-6-phosphatase-related protein (IGRP).
Anthony J Petrolonis, Qing Yang, Peter J Tummino, Susan M Fish, Andrea E Prack, Steven P Langston

J Biol Chem· April 2004

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