Publications by authors named "Steven Ludmerer"

Claim this Profile
M
Multi-step parallel synthesis enabled optimization of benzofuran derivatives as pan-genotypic non-nucleoside inhibitors of HCV NS5B.
Dong Xiao, Xing Dai, Hong Liu, Shuwen He, Zhi-Cai Shi, Steven W Ludmerer

Bioorg Med Chem Lett· April 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design and evaluation of novel tetracyclic benzofurans as palm site allosteric inhibitors of HCV NS5B polymerase.
Hong Liu, Xing Dai, Shuwen He, Linda Brockunier, Karen Marcantonio, Steven W Ludmerer

Bioorg Med Chem Lett· December 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Development of a New Structural Class of Broadly Acting HCV Non-Nucleoside Inhibitors Leading to the Discovery of MK-8876.
Casey C McComas, Anandan Palani, Wei Chang, M Katharine Holloway, Charles A Lesburg, Steven W Ludmerer

ChemMedChem· September 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
HCV evolutionary genetics of SVR versus virologic failure assessed from the vaniprevir phase III registration trials.
Steven W Ludmerer, Tomona Hirano, Stuart Black, Anita Y M Howe, Wei Chang

Antiviral Res· June 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
V
Vaniprevir plus peginterferon alfa-2b and ribavirin in treatment-naive Japanese patients with hepatitis C virus genotype 1 infection: a randomized phase III study.
Norio Hayashi, Makoto Nakamuta, Tetsuo Takehara, Hiromitsu Kumada, Akiko Takase, Steven W Ludmerer

J Gastroenterol· April 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Susceptibilities of genotype 1a, 1b, and 3 hepatitis C virus variants to the NS5A inhibitor elbasvir.
Rong Liu, Stephanie Curry, Patricia McMonagle, Wendy W Yeh, Steven W Ludmerer

Antimicrob Agents Chemother· November 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
P2-quinazolinones and bis-macrocycles as new templates for next-generation hepatitis C virus NS3/4a protease inhibitors: discovery of MK-2748 and MK-6325.
Michael T Rudd, John W Butcher, Kevin T Nguyen, Charles J McIntyre, Joseph J Romano, Steven W Ludmerer

ChemMedChem· April 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
V
Virologic resistance analysis from a phase 2 study of MK-5172 combined with pegylated interferon/ribavirin in treatment-naive patients with hepatitis C virus genotype 1 infection.
Anita Y M Howe, Stuart Black, Stephanie Curry, Steven W Ludmerer, Rong Liu

Clin Infect Dis· December 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of MK-8742: an HCV NS5A inhibitor with broad genotype activity.
Craig A Coburn, Peter T Meinke, Wei Chang, Christine M Fandozzi, Donald J Graham, Steven W Ludmerer

ChemMedChem· December 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease.
Michael T Rudd, John A McCauley, Joseph J Romano, John W Butcher, Kimberly Bush, Steven W Ludmerer

Bioorg Med Chem Lett· December 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2-P4 linkers.
Michael T Rudd, Charles J McIntyre, Joseph J Romano, John W Butcher, M Katharine Holloway, Steven W Ludmerer

Bioorg Med Chem Lett· December 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants.
Vincenzo Summa, Steven W Ludmerer, John A McCauley, Christine Fandozzi, Christine Burlein

Antimicrob Agents Chemother· August 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor.
Steven Harper, John A McCauley, Michael T Rudd, Marco Ferrara, Marcello DiFilippo, Steven W Ludmerer

ACS Med Chem Lett· April 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of MK-1220: A Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure.
Michael T Rudd, John A McCauley, John W Butcher, Joseph J Romano, Charles J McIntyre, Steven W Ludmerer

ACS Med Chem Lett· March 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Sustained viral response in a hepatitis C virus-infected chimpanzee via a combination of direct-acting antiviral agents.
David B Olsen, Mary-Ellen Davies, Larry Handt, Kenneth Koeplinger, Nanyan Rena Zhang, Steven W Ludmerer

Antimicrob Agents Chemother· February 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of vaniprevir (MK-7009), a macrocyclic hepatitis C virus NS3/4a protease inhibitor.
John A McCauley, Charles J McIntyre, Michael T Rudd, Kevin T Nguyen, Joseph J Romano, Steven W Ludmerer

J Med Chem· March 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease.
Nigel J Liverton, Steven S Carroll, Jillian Dimuzio, Christine Fandozzi, Donald J Graham, Steven W Ludmerer

Antimicrob Agents Chemother· January 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structural basis for resistance of the genotype 2b hepatitis C virus NS5B polymerase to site A non-nucleoside inhibitors.
Edwin H Rydberg, Antonella Cellucci, Linda Bartholomew, Marco Mattu, Gaetano Barbato, Steven W Ludmerer

J Mol Biol· July 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Robust antiviral efficacy upon administration of a nucleoside analog to hepatitis C virus-infected chimpanzees.
Steven S Carroll, Steven Ludmerer, Larry Handt, Kenneth Koeplinger, Nanyan Rena Zhang

Antimicrob Agents Chemother· March 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A transient cell-based phenotype assay for hepatitis C NS3/4A protease: application to potency determinations of a novel macrocyclic inhibitor against diverse protease sequences isolated from plasma infected with HCV.
Steven W Ludmerer, Donald J Graham, Mihir Patel, Kevin Gilbert, Mark Stahlhut

J Virol Methods· August 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A genotype 2b NS5B polymerase with novel substitutions supports replication of a chimeric HCV 1b:2b replicon containing a genotype 1b NS3-5A background.
Donald J Graham, Mark Stahlhut, Osvaldo Flores, David B Olsen, Daria J Hazuda, Steven W Ludmerer

Antiviral Res· January 2006

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Replication fitness and NS5B drug sensitivity of diverse hepatitis C virus isolates characterized by using a transient replication assay.
Steven W Ludmerer, Donald J Graham, Evelyn Boots, Edward M Murray, Amy Simcoe

Antimicrob Agents Chemother· May 2005

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro.
Giovanni Migliaccio, Joanne E Tomassini, Steven S Carroll, Licia Tomei, Sergio Altamura, Steven W Ludmerer

J Biol Chem· December 2003

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
Human papillomavirus type 6 virus-like particles present overlapping yet distinct conformational epitopes.
Xin-Min Wang, James C Cook, Jessica C Lee, Kathrin U Jansen, Neil D Christensen, Steven W Ludmerer

J Gen Virol· June 2003

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Ivermectin and nodulisporic acid receptors in Drosophila melanogaster contain both gamma-aminobutyric acid-gated Rdl and glutamate-gated GluCl alpha chloride channel subunits.
Steven W Ludmerer, Vivien A Warren, Brande S Williams, Yingcong Zheng, David C Hunt

Biochemistry· May 2002

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis