Publications by authors named "Steven Molinski"

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Comprehensive mapping of cystic fibrosis mutations to CFTR protein identifies mutation clusters and molecular docking predicts corrector binding site.
Steven V Molinski, Vijay M Shahani, Adithya S Subramanian, Stephen S MacKinnon, Geoffrey Woollard

Proteins· August 2018

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Correctors of the Major Cystic Fibrosis Mutant Interact through Membrane-Spanning Domains.
Onofrio Laselva, Steven Molinski, Valeria Casavola, Christine E Bear

Mol Pharmacol· June 2018

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The Antiretroviral Agent Nelfinavir Mesylate: A Potential Therapy for Systemic Sclerosis.
Cecilia G Sanchez, Steven V Molinski, Rafael Gongora, Meredith Sosulski, Taylor Fuselier

Arthritis Rheumatol· January 2018

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Giving Drugs a Second Chance: Overcoming Regulatory and Financial Hurdles in Repurposing Approved Drugs As Cancer Therapeutics.
J Javier Hernandez, Michael Pryszlak, Lindsay Smith, Connor Yanchus, Naheed Kurji, Steven V Molinski

Front Oncol· November 2017

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Orkambi® and amplifier co-therapy improves function from a rare mutation in gene-edited cells and patient tissue.
Steven V Molinski, Saumel Ahmadi, Wan Ip, Hong Ouyang, Adriana Villella

EMBO Mol Med· September 2017

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Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia.
Saumel Ahmadi, Zoltan Bozoky, Michelle Di Paola, Sunny Xia, Canhui Li, Steven V Molinski

NPJ Genom Med· April 2017

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Biophysical Approaches Facilitate Computational Drug Discovery for ATP-Binding Cassette Proteins.
Steven V Molinski, Zoltán Bozóky, Surtaj H Iram, Saumel Ahmadi

Int J Med Chem· March 2017

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Attenuation of Phosphorylation-dependent Activation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Disease-causing Mutations at the Transmission Interface.
Stephanie Chin, Donghe Yang, Andrew J Miles, Paul D W Eckford, Steven Molinski

J Biol Chem· February 2017

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Computational proteome-wide screening predicts neurotoxic drug-protein interactome for the investigational analgesic BIA 10-2474.
Steven V Molinski, Vijay M Shahani, Stephen S MacKinnon, Leonard D Morayniss, Marcon Laforet

Biochem Biophys Res Commun· January 2017

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The investigational Cystic Fibrosis drug Trimethylangelicin directly modulates CFTR by stabilizing the first membrane-spanning domain.
Onofrio Laselva, Steven Molinski, Valeria Casavola, Christine E Bear

Biochem Pharmacol· November 2016

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Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity.
Firhan A Malik, Anja Meissner, Illya Semenkov, Steven Molinski, Stan Pasyk

PLoS One· April 2016

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Facilitating Structure-Function Studies of CFTR Modulator Sites with Efficiencies in Mutagenesis and Functional Screening.
Steven V Molinski, Saumel Ahmadi, Maurita Hung, Christine E Bear

J Biomol Screen· December 2015

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The major cystic fibrosis causing mutation exhibits defective propensity for phosphorylation.
Stan Pasyk, Steven Molinski, Saumel Ahmadi, Mohabir Ramjeesingh, Ling-Jun Huan

Proteomics· January 2015

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Genetic, cell biological, and clinical interrogation of the CFTR mutation c.3700 A>G (p.Ile1234Val) informs strategies for future medical intervention.
Steven V Molinski, Tanja Gonska, Ling Jun Huan, Berivan Baskin, Ibrahim A Janahi

Genet Med· August 2014

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VX-809 and related corrector compounds exhibit secondary activity stabilizing active F508del-CFTR after its partial rescue to the cell surface.
Paul D W Eckford, Mohabir Ramjeesingh, Steven Molinski, Stan Pasyk, Johanna F Dekkers

Chem Biol· May 2014

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Conformational defects underlie proteasomal degradation of Dent's disease-causing mutants of ClC-5.
Christina D'Antonio, Steven Molinski, Saumel Ahmadi, Ling-Jun Huan, Leigh Wellhauser

Biochem J· June 2013

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Functional Rescue of F508del-CFTR Using Small Molecule Correctors.
Steven Molinski, Paul D W Eckford, Stan Pasyk, Saumel Ahmadi, Stephanie Chin

Front Pharmacol· October 2012

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Identification and validation of hits from high throughput screens for CFTR modulators.
Stan Pasyk, Steven Molinski, Wilson Yu, Paul D W Eckford, Christine E Bear

Curr Pharm Des· June 2012

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Mammalian multidrug-resistance proteins (MRPs).
Andrew J Slot, Steven V Molinski, Susan P C Cole

Essays Biochem· September 2011

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Platelet and red blood cell phagocytosis kinetics are differentially controlled by phosphatase activity within mononuclear cells.
Rukhsana Aslam, Michael Kim, Edwin R Speck, Arjuna Contram Seetanah, Steven Molinski

Transfusion· November 2007

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