Publications by authors named "Mohabir Ramjeesingh"

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Comparison of a novel potentiator of CFTR channel activity to ivacaftor in ameliorating mucostasis caused by cigarette smoke in primary human bronchial airway epithelial cells.
Adrian Constantin Tanjala, Jia Xin Jiang, Paul D W Eckford, Mohabir Ramjeesingh, Canhui Li

Respir Res· July 2024

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Comparison of a novel potentiator of CFTR channel activity to ivacaftor in ameliorating mucostasis caused by cigarette smoke in primary human bronchial airway epithelial cells.
Adrian Constantin Tanjala, Jia Xin Jiang, Paul D W Eckford, Mohabir Ramjeesingh, Canhui Li

bioRxiv· March 2024

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Identification of binding sites for ivacaftor on the cystic fibrosis transmembrane conductance regulator.
Onofrio Laselva, Zafar Qureshi, Zhi-Wei Zeng, Evgeniy V Petrotchenko, Mohabir Ramjeesingh

iScience· June 2021

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Cholesterol Interaction Directly Enhances Intrinsic Activity of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).
Stephanie Chin, Mohabir Ramjeesingh, Maurita Hung, June Ereño-Oreba, Hong Cui

Cells· July 2019

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Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop.
Annette Ehrhardt, W Joon Chung, Louise C Pyle, Wei Wang, Krzysztof Nowotarski, Mohabir Ramjeesingh

J Biol Chem· January 2016

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The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor.
Steven D Broadbent, Mohabir Ramjeesingh, Christine E Bear, Barry E Argent, Paul Linsdell

Pflugers Arch· August 2015

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The major cystic fibrosis causing mutation exhibits defective propensity for phosphorylation.
Stan Pasyk, Steven Molinski, Saumel Ahmadi, Mohabir Ramjeesingh, Ling-Jun Huan

Proteomics· January 2015

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VX-809 and related corrector compounds exhibit secondary activity stabilizing active F508del-CFTR after its partial rescue to the cell surface.
Paul D W Eckford, Mohabir Ramjeesingh, Steven Molinski, Stan Pasyk, Johanna F Dekkers

Chem Biol· May 2014

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Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner.
Paul D W Eckford, Canhui Li, Mohabir Ramjeesingh, Christine E Bear

J Biol Chem· October 2012

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A chemical corrector modifies the channel function of F508del-CFTR.
Patrick Kim Chiaw, Leigh Wellhauser, Ling Jun Huan, Mohabir Ramjeesingh, Christine E Bear

Mol Pharmacol· September 2010

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A small-molecule modulator interacts directly with deltaPhe508-CFTR to modify its ATPase activity and conformational stability.
Leigh Wellhauser, Patrick Kim Chiaw, Stan Pasyk, Canhui Li, Mohabir Ramjeesingh

Mol Pharmacol· June 2009

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Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease.
Stan Pasyk, Canhui Li, Mohabir Ramjeesingh, Christine E Bear

Biochem J· February 2009

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The intact CFTR protein mediates ATPase rather than adenylate kinase activity.
Mohabir Ramjeesingh, Francisca Ugwu, Fiona L L Stratford, Ling-Jun Huan, Canhui Li

Biochem J· June 2008

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Probing structure-function relationships and gating mechanisms in the CorA Mg2+ transport system.
Jian Payandeh, Canhui Li, Mohabir Ramjeesingh, Ewa Poduch, Christine E Bear

J Biol Chem· April 2008

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The Walker B motif of the second nucleotide-binding domain (NBD2) of CFTR plays a key role in ATPase activity by the NBD1-NBD2 heterodimer.
Fiona L L Stratford, Mohabir Ramjeesingh, Joanne C Cheung, Ling-Jun Huan, Christine E Bear

Biochem J· January 2007

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Nucleotides bind to the C-terminus of ClC-5.
Leigh Wellhauser, Hsin-Hen Kuo, Fiona L L Stratford, Mohabir Ramjeesingh, Ling-Jun Huan

Biochem J· September 2006

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Evaluation of the membrane-spanning domain of ClC-2.
Mohabir Ramjeesingh, Canhui Li, Yi-Min She, Christine E Bear

Biochem J· June 2006

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A heteromeric complex of the two nucleotide binding domains of cystic fibrosis transmembrane conductance regulator (CFTR) mediates ATPase activity.
Jackie F Kidd, Mohabir Ramjeesingh, Fiona Stratford, Ling-Jun Huan, Christine E Bear

J Biol Chem· October 2004

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Methods to study CFTR protein in vitro.
Dale J Benos, Bakhrom K Berdiev, Iskander I Ismailov, Lynda S Ostedgaard, Ilana Kogan, Mohabir Ramjeesingh

J Cyst Fibros· August 2004

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The patch-clamp and planar lipid bilayer techniques: powerful and versatile tools to investigate the CFTR Cl- channel.
David N Sheppard, Michael A Gray, Xiandi Gong, Yoshiro Sohma, Ilana Kogan, Mohabir Ramjeesingh

J Cyst Fibros· August 2004

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Determination of CFTR chloride channel activity and pharmacology using radiotracer flux methods.
Caroline Norez, Ghanshyam D Heda, Timothy Jensen, Ilana Kogan, Lauren K Hughes, Mohabir Ramjeesingh

J Cyst Fibros· August 2004

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ATPase assay of purified, reconstituted CFTR protein.
Ilana Kogan, Mohabir Ramjeesingh, Christine E Bear

J Cyst Fibros· August 2004

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Phosphorylation-induced conformational changes of cystic fibrosis transmembrane conductance regulator monitored by attenuated total reflection-Fourier transform IR spectroscopy and fluorescence spectroscopy.
Vinciane Grimard, Canhui Li, Mohabir Ramjeesingh, Christine E Bear, Erik Goormaghtigh

J Biol Chem· February 2004

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Stable dimeric assembly of the second membrane-spanning domain of CFTR (cystic fibrosis transmembrane conductance regulator) reconstitutes a chloride-selective pore.
Mohabir Ramjeesingh, Francisca Ugwu, Canhui Li, Sonja Dhani, Ling Jun Huan

Biochem J· November 2003

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Dimeric cystic fibrosis transmembrane conductance regulator exists in the plasma membrane.
Mohabir Ramjeesingh, Jackie F Kidd, Ling Jun Huan, Yanchun Wang, Christine E Bear

Biochem J· September 2003

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