Publications by authors named "Steven Whittaker"

Claim this Profile
D
Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays.
Olivier A Pierrat, Manjuan Liu, Gavin W Collie, Kartika Shetty, Matthew J Rodrigues, Steven Whittaker

Sci Rep· November 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Tissue-Specific Human Extracellular Matrix Scaffolds Promote Pancreatic Tumour Progression and Chemotherapy Resistance.
Walid Al-Akkad, Pilar Acedo, Maria-Giovanna Vilia, Luca Frenguelli, Alexander Ney, Steven R Whittaker

Cells· November 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A phospho-proteomic study of cetuximab resistance in KRAS/NRAS/BRAF wild-type colorectal cancer.
Alexandros Georgiou, Adam Stewart, Georgios Vlachogiannis, Lisa Pickard, Nicola Valeri, Steven R Whittaker

Cell Oncol (Dordr)· October 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A Genome-scale CRISPR Screen Identifies the ERBB and mTOR Signaling Networks as Key Determinants of Response to PI3K Inhibition in Pancreatic Cancer.
Charlotte K Milton, Annette J Self, Paul A Clarke, Udai Banerji, Federica Piccioni, Steven R Whittaker

Mol Cancer Ther· July 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Inactivation of Promotes Resistance to EGFR Inhibition in -Wild-Type Colorectal Cancer.
Alexandros Georgiou, Adam Stewart, David Cunningham, Udai Banerji, Steven R Whittaker

Mol Cancer Res· June 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Combined targeting of MEK and the glucocorticoid receptor for the treatment of RAS-mutant multiple myeloma.
Priya Sriskandarajah, Alexis De Haven Brandon, Kenneth MacLeod, Neil O Carragher, Vladimir Kirkin, Steven R Whittaker

BMC Cancer· March 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Increased inflammatory lipid metabolism and anaplerotic mitochondrial activation follow acquired resistance to vemurafenib in BRAF-mutant melanoma cells.
Teresa Delgado-Goñi, Teresa Casals Galobart, Slawomir Wantuch, Deimante Normantaite, Martin O Leach, Steven R Whittaker

Br J Cancer· January 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Correction: Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer.
Steve Wagner, Georgios Vlachogiannis, Alexis De Haven Brandon, Melanie Valenti, Gary Box, Steven R Whittaker

Oncogene· July 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer.
Steve Wagner, Georgios Vlachogiannis, Alexis De Haven Brandon, Melanie Valenti, Gary Box, Steven R Whittaker

Oncogene· March 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor.
Steven R Whittaker, Clare Barlow, Mathew P Martin, Caterina Mancusi, Steve Wagner

Mol Oncol· March 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Inhibitors of cyclin-dependent kinases as cancer therapeutics.
Steven R Whittaker, Aurélie Mallinger, Paul Workman, Paul A Clarke

Pharmacol Ther· May 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma.
Maria Romina Girotti, Filipa Lopes, Natasha Preece, Dan Niculescu-Duvaz, Alfonso Zambon, Steven Whittaker

Cancer Cell· March 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Combined Pan-RAF and MEK Inhibition Overcomes Multiple Resistance Mechanisms to Selective RAF Inhibitors.
Steven R Whittaker, Glenn S Cowley, Steve Wagner, Flora Luo, David E Root

Mol Cancer Ther· December 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma.
Maria Romina Girotti, Filipa Lopes, Natasha Preece, Dan Niculescu-Duvaz, Alfonso Zambon, Steven Whittaker

Cancer Cell· January 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma.
Eliezer M Van Allen, Nikhil Wagle, Antje Sucker, Daniel J Treacy, Cory M Johannessen, Steven Whittaker

Cancer Discov· January 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Automated low flow pump system for the treatment of refractory ascites: a multi-center safety and efficacy study.
Pablo Bellot, Martin-Walter Welker, German Soriano, Markus von Schaewen, Beate Appenrodt, Steven Whittaker

J Hepatol· May 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition.
Steven R Whittaker, Jean-Philippe Theurillat, Eliezer Van Allen, Nikhil Wagle, Jessica Hsiao

Cancer Discov· March 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents.
Dan Niculescu-Duvaz, Ion Niculescu-Duvaz, Bart M J M Suijkerbuijk, Delphine Ménard, Alfonso Zambon, Steven Whittaker

Bioorg Med Chem· March 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors.
Stuart C Wilson, Butrus Atrash, Clare Barlow, Susan Eccles, Peter M Fischer, Steven Whittaker

Bioorg Med Chem· November 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A novel, selective, and efficacious nanomolar pyridopyrazinone inhibitor of V600EBRAF.
Steven Whittaker, Delphine Ménard, Ruth Kirk, Lesley Ogilvie, Douglas Hedley

Cancer Res· October 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds.
Dan Niculescu-Duvaz, Ion Niculescu-Duvaz, Bart M J M Suijkerbuijk, Delphine Ménard, Alfonso Zambon, Steven Whittaker

Bioorg Med Chem· September 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Novel hinge binder improves activity and pharmacokinetic properties of BRAF inhibitors.
Alfonso Zambon, Delphine Ménard, Bart M J M Suijkerbuijk, Ion Niculescu-Duvaz, Steven Whittaker

J Med Chem· August 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
All roads lead to the ribosome.
Steven Whittaker, Matthew Martin, Richard Marais

Cancer Cell· July 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
G
Gatekeeper mutations mediate resistance to BRAF-targeted therapies.
Steven Whittaker, Ruth Kirk, Robert Hayward, Alfonso Zambon, Amaya Viros

Sci Transl Med· June 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Development of novel, highly potent inhibitors of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF): increasing cellular potency through optimization of a distal heteroaromatic group.
Bart M J M Suijkerbuijk, Ion Niculescu-Duvaz, Catherine Gaulon, Harmen P Dijkstra, Dan Niculescu-Duvaz, Steven Whittaker

J Med Chem· April 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis