Publications by authors named "Stuart Emanuel"

Claim this Profile
T
The discovery of macrocyclic XIAP antagonists from a DNA-programmed chemistry library, and their optimization to give lead compounds with in vivo antitumor activity.
Benjamin A Seigal, William H Connors, Andrew Fraley, Robert M Borzilleri, Percy H Carter, Stuart L Emanuel

J Med Chem· March 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of potent heterodimeric antagonists of inhibitor of apoptosis proteins (IAPs) with sustained antitumor activity.
Heidi L Perez, Charu Chaudhry, Stuart L Emanuel, Caroline Fanslau, Joseph Fargnoli

J Med Chem· February 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of tetrahydroisoquinoline-based bivalent heterodimeric IAP antagonists.
Kyoung Soon Kim, Liping Zhang, David Williams, Heidi L Perez, Erik Stang, Stuart Emanuel

Bioorg Med Chem Lett· November 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Development of a carbon-14 labeling approach to support disposition studies with a pegylated biologic.
Haiqing Wang, Lifei Wang, Kai Cao, Stuart L Emanuel, Paul Morin

Drug Metab Dispos· September 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structures of adnectin/protein complexes reveal an expanded binding footprint.
Vidhyashankar Ramamurthy, Stanley R Krystek, Alexander Bush, Anzhi Wei, Stuart L Emanuel

Structure· February 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor.
Stuart L Emanuel, Linda J Engle, Ginger Chao, Rong-Rong Zhu, Carolyn Cao

MAbs· July 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Antitumor and antiangiogenic activities of BMS-690514, an inhibitor of human EGF and VEGF receptor kinase families.
Tai W Wong, Francis Y Lee, Stuart Emanuel, Craig Fairchild, Joseph Fargnoli

Clin Cancer Res· June 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of anticancer agents of diverse natural origin.
A Douglas Kinghorn, Esperanza J Carcache de Blanco, Hee-Byung Chai, Jimmy Orjala, Norman R Farnsworth, Stuart Emanuel

Pure Appl Chem· January 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine having dual EGFR/HER2 kinase activity: design, synthesis, and biological activity.
Terry V Hughes, Guozhang Xu, Steven K Wetter, Peter J Connolly, Stuart L Emanuel

Bioorg Med Chem Lett· September 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
7
7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors: design, synthesis, and biological activity.
Terry V Hughes, Stuart L Emanuel, Harold R O'Grady, Peter J Connolly, Catherine Rugg

Bioorg Med Chem Lett· September 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
4
4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitors.
Guozhang Xu, Marta C Abad, Peter J Connolly, Michael P Neeper, Geoffrey T Struble, Stuart L Emanuel

Bioorg Med Chem Lett· August 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR and ErbB-2 protein tyrosine kinases.
Guozhang Xu, Lily Lee Searle, Terry V Hughes, Amanda K Beck, Peter J Connolly, Stuart L Emanuel

Bioorg Med Chem Lett· June 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Cellular and in vivo activity of JNJ-28871063, a nonquinazoline pan-ErbB kinase inhibitor that crosses the blood-brain barrier and displays efficacy against intracranial tumors.
Stuart L Emanuel, Terry V Hughes, Mary Adams, Catherine A Rugg, Angel Fuentes-Pesquera

Mol Pharmacol· February 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents.
Ronghui Lin, Peter J Connolly, Yanhua Lu, George Chiu, Shengjian Li, Stuart L Emanuel

Bioorg Med Chem Lett· August 2007

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design, synthesis, and evaluation of 3,4-disubstituted pyrazole analogues as anti-tumor CDK inhibitors.
Ronghui Lin, George Chiu, Yang Yu, Peter J Connolly, Shengjian Li, Stuart L Emanuel

Bioorg Med Chem Lett· August 2007

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
4
4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: synthesis and biological evaluation.
Terry V Hughes, Stuart L Emanuel, Amanda K Beck, Steven K Wetter, Peter J Connolly

Bioorg Med Chem Lett· June 2007

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis and biological study of 2-amino-4-aryl-5-chloropyrimidine analogues as inhibitors of VEGFR-2 and cyclin dependent kinase 1 (CDK1).
Shenlin Huang, Ronghua Li, Peter J Connolly, Stuart Emanuel, Angel Fuentes-Pesquera

Bioorg Med Chem Lett· April 2007

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis of 3-(1H-benzimidazol-2-yl)-5-isoquinolin-4-ylpyrazolo[1,2-b]pyridine, a potent cyclin dependent kinase 1 (CDK1) inhibitor.
Shenlin Huang, Ronghui Lin, Yang Yu, Yanhua Lu, Peter J Connolly, Stuart L Emanuel

Bioorg Med Chem Lett· March 2007

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis and biological study of 4-aminopyrimidine-5-carboxaldehyde oximes as antiproliferative VEGFR-2 inhibitors.
Shenlin Huang, Ronghua Li, Peter J Connolly, Guozhang Xu, Michael D Gaul, Stuart L Emanuel

Bioorg Med Chem Lett· December 2006

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Role of the ABCG2 drug transporter in the resistance and oral bioavailability of a potent cyclin-dependent kinase/Aurora kinase inhibitor.
Jennifer A Seamon, Catherine A Rugg, Stuart Emanuel, Anna Maria Calcagno, Suresh V Ambudkar

Mol Cancer Ther· October 2006

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis of 2-amino-4-(7-azaindol-3-yl)pyrimidines as cyclin dependent kinase 1 (CDK1) inhibitors.
Shenlin Huang, Ronghua Li, Peter J Connolly, Stuart Emanuel, Steven A Middleton

Bioorg Med Chem Lett· September 2006

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis and evaluation of N-acyl sulfonamides as potential prodrugs of cyclin-dependent kinase inhibitor JNJ-7706621.
Shenlin Huang, Peter J Connolly, Ronghui Lin, Stuart Emanuel, Steve A Middleton

Bioorg Med Chem Lett· July 2006

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
(
(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells.
Chih Y Ho, Donald W Ludovici, Umar S M Maharoof, Jay Mei, Jan L Sechler, Stuart Emanuel

J Med Chem· December 2005

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The in vitro and in vivo effects of JNJ-7706621: a dual inhibitor of cyclin-dependent kinases and aurora kinases.
Stuart Emanuel, Catherine A Rugg, Robert H Gruninger, Ronghui Lin, Angel Fuentes-Pesquera

Cancer Res· October 2005

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis and structure-activity relationships of pyrazine-pyridine biheteroaryls as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors.
Gee-Hong Kuo, Catherine Prouty, Aihua Wang, Stuart Emanuel, Alan Deangelis

J Med Chem· July 2005

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis