Publications by authors named "Subas Sakya"

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Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors.
Michael A Brodney, Elizabeth M Beck, Christopher R Butler, Gabriela Barreiro, Eric F Johnson, Subas M Sakya

J Med Chem· April 2015

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Synthetic approaches to the 2012 new drugs.
Hong X Ding, Carolyn A Leverett, Robert E Kyne, Kevin K-C Liu, Subas M Sakya

Bioorg Med Chem· April 2014

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Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione γ-secretase modulators.
Martin Pettersson, Douglas S Johnson, Chakrapani Subramanyam, Kelly R Bales, Christopher W am Ende, Subas M Sakya

J Med Chem· February 2014

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Synthetic approaches to the 2011 new drugs.
Hong X Ding, Kevin K-C Liu, Subas M Sakya, Andrew C Flick, Christopher J O'Donnell

Bioorg Med Chem· June 2013

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Stereoselective synthesis of spiropiperidines as BACE-1 aspartyl protease inhibitors via late stage N-arylation of a 1,8-diazaspiro[4.5]dec-3-en-2-one pharmacophore.
Che-Wah Lee, Ricardo Lira, Jason Dutra, Kevin Ogilvie, Brian T O'Neill, Subas Sakya

J Org Chem· March 2013

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Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators.
Martin Pettersson, Douglas S Johnson, Chakrapani Subramanyam, Kelly R Bales, Christopher W am Ende, Subas M Sakya

Bioorg Med Chem Lett· April 2012

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Synthetic approaches to the 2010 new drugs.
Kevin K-C Liu, Subas M Sakya, Christopher J O'Donnell, Andrew C Flick, Hong X Ding

Bioorg Med Chem· February 2012

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6-amino-4-(pyrimidin-4-yl)pyridones: novel glycogen synthase kinase-3β inhibitors.
Karen Coffman, Michael Brodney, James Cook, Lorraine Lanyon, Jayvardhan Pandit, Subas Sakya

Bioorg Med Chem Lett· March 2011

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Synthetic approaches to the 2009 new drugs.
Kevin K-C Liu, Subas M Sakya, Christopher J O'Donnell, Andrew C Flick, Jin Li

Bioorg Med Chem· February 2011

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Synthetic approaches to the 2008 new drugs.
Kevin K-C Liu, Subas M Sakya, Christopher J O'Donnell, Jin Li

Mini Rev Med Chem· December 2009

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Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors.
Allen J Duplantier, Stacey L Becker, Michael J Bohanon, Kris A Borzilleri, Boris A Chrunyk, Subas M Sakya

J Med Chem· June 2009

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Synthetic approaches to the 2007 new drugs.
Kevin K-C Liu, Subas M Sakya, Christopher J O'Donnell, Jin Li

Mini Rev Med Chem· December 2008

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Comparative structure-activity relationship studies of 1-(5-methylsulfonylpyrid-2-yl)-5-alkyl and (hetero)aryl triazoles and pyrazoles in canine COX inhibition.
Subas M Sakya, Andrei Shavnya, Hengmiao Cheng, Chao Li, Bryson Rast

Bioorg Med Chem Lett· February 2008

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Synthetic approaches to the 2006 new drugs.
Kevin K-C Liu, Subas M Sakya, Jin Li

Mini Rev Med Chem· December 2007

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Synthetic approaches to the 2005 new drugs.
Subas M Sakya, Jin Li, Kevin K-C Liu

Mini Rev Med Chem· April 2007

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5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part III: molecular modeling studies on binding contribution of 1-(5-methylsulfonyl)pyrid-2-yl and 4-nitrile.
Subas M Sakya, Xinjun Hou, Martha L Minich, Bryson Rast, Andrei Shavnya

Bioorg Med Chem Lett· February 2007

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Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors.
Hengmiao Cheng, Kristin M Lundy DeMello, Jin Li, Subas M Sakya, Kazuo Ando

Bioorg Med Chem Lett· April 2006

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5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure-activity relationship studies of 5-alkylethers and 5-thioethers.
Subas M Sakya, Hengmiao Cheng, Kristin M Lundy Demello, Andrei Shavnya, Martha L Minich

Bioorg Med Chem Lett· March 2006

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New bicyclic cannabinoid receptor-1 (CB1-R) antagonists.
Philip A Carpino, David A Griffith, Subas Sakya, Robert L Dow, Shawn C Black

Bioorg Med Chem Lett· February 2006

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5-heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure-activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog.
Subas M Sakya, Kristin M Lundy DeMello, Martha L Minich, Bryson Rast, Andrei Shavnya

Bioorg Med Chem Lett· January 2006

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Synthetic approaches to the 2004 new drugs.
Jin Li, Kevin K-C Liu, Subas Sakya

Mini Rev Med Chem· December 2005

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In vitro and in vivo profile of 2-(3-di-fluoromethyl-5-phenylpyrazol-1-yl)-5-methanesulfonylpyridine, a potent, selective, and orally active canine COX-2 inhibitor.
Jin Li, Michael P Lynch, Kristin Lundy Demello, Subas M Sakya, Hengmiao Cheng

Bioorg Med Chem· March 2005

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Synthetic approaches to the 2003 new drugs.
Kevin K-C Liu, Jin Li, Subas Sakya

Mini Rev Med Chem· December 2004

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Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine.
Jin Li, Kristin M Lundy DeMello, Henry Cheng, Subas M Sakya, Brian S Bronk

Bioorg Med Chem Lett· January 2004

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Azalide 3,6-ketals: antibacterial activity and structure-activity relationships of aryl and hetero aryl substituted analogues.
Subas M Sakya, Peter Bertinato, Bryan Pratt, Melani Suarez-Contreras, Kristin M Lundy

Bioorg Med Chem Lett· April 2003

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