Publications by authors named "Susan Catalano"

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Drug Development.
Michael Grundman, Susan Catalano, Mary E Hamby, Theresa Devins, Jennifer Iaci

Alzheimers Dement· December 2025

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Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer's disease.
Martí Colom-Cadena, Jamie Toombs, Elizabeth Simzer, Kristjan Holt, Robert McGeachan, Susan M Catalano

Acta Neuropathol· February 2024

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A pilot study to evaluate the effect of CT1812 treatment on synaptic density and other biomarkers in Alzheimer's disease.
Christopher H van Dyck, Adam P Mecca, Ryan S O'Dell, Hugh H Bartlett, Nina G Diepenbrock, Susan M Catalano

Alzheimers Res Ther· January 2024

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A phase 1b randomized clinical trial of CT1812 to measure Aβ oligomer displacement in Alzheimer's disease using an indwelling CSF catheter.
Kelsie M LaBarbera, Yvette I Sheline, Nicholas J Izzo, Carla M Yuede, Lora Waybright, Susan M Catalano

Transl Neurodegener· May 2023

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Sigma-2 Receptors-From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases.
Britney N Lizama, Jennifer Kahle, Susan M Catalano, Anthony O Caggiano, Michael Grundman

Int J Mol Sci· March 2023

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Exploration of Diazaspiro Cores as Piperazine Bioisosteres in the Development of σ2 Receptor Ligands.
Kuiying Xu, Chia-Ju Hsieh, Ji Youn Lee, Aladdin Riad, Nicholas J Izzo, Susan Catalano

Int J Mol Sci· July 2022

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Screening of σ Receptor Ligands and Evaluation of C-Labeled 6,7-Dimethoxy-2-[4-(4-methoxyphenyl)butan-2-yl]-1,2,3,4-tetrahydroisoquinoline for Potential Use as a σ Receptor Brain PET Tracer.
Ho Young Kim, Ji Youn Lee, Chia-Ju Hsieh, Aladdin Riad, Nicholas J Izzo, Susan M Catalano

J Med Chem· April 2022

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Discovery of Investigational Drug CT1812, an Antagonist of the Sigma-2 Receptor Complex for Alzheimer's Disease.
Gilbert M Rishton, Gary C Look, Zhi-Jie Ni, Jason Zhang, Yingcai Wang, Susan M Catalano

ACS Med Chem Lett· September 2021

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Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification.
Nicholas J Izzo, Carla M Yuede, Kelsie M LaBarbera, Colleen S Limegrover, Courtney Rehak, Susan M Catalano

Alzheimers Dement· August 2021

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Modeling the mature CNS: A predictive screening platform for neurodegenerative disease drug discovery.
Kelsie Mozzoni LaBarbera, Colleen Limegrover, Courtney Rehak, Raymond Yurko, Nicholas John Izzo, Susan M Catalano

J Neurosci Methods· July 2021

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Proceedings from the Fourth International Symposium on σ-2 Receptors: Role in Health and Disease.
Nicholas J Izzo, Martí Colom-Cadena, Aladdin A Riad, Jinbin Xu, Meharvan Singh, Susan M Catalano

eNeuro· June 2021

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Alzheimer's protection effect of A673T mutation may be driven by lower Aβ oligomer binding affinity.
Colleen S Limegrover, Harry LeVine, Nicholas J Izzo, Raymond Yurko, Kelsie Mozzoni, Susan M Catalano

J Neurochem· May 2021

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Sigma-2 receptor antagonists rescue neuronal dysfunction induced by Parkinson's patient brain-derived α-synuclein.
Colleen S Limegrover, Raymond Yurko, Nicholas J Izzo, Kelsie M LaBarbera, Courtney Rehak, Susan M Catalano

J Neurosci Res· April 2021

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The clinical promise of biomarkers of synapse damage or loss in Alzheimer's disease.
Martí Colom-Cadena, Tara Spires-Jones, Henrik Zetterberg, Kaj Blennow, Anthony Caggiano, Susan M Catalano

Alzheimers Res Ther· March 2020

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A phase 1 clinical trial of the sigma-2 receptor complex allosteric antagonist CT1812, a novel therapeutic candidate for Alzheimer's disease.
Michael Grundman, Roger Morgan, Jason D Lickliter, Lon S Schneider, Steven DeKosky, Susan M Catalano

Alzheimers Dement (N Y)· January 2019

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The emerging role of progesterone receptor membrane component 1 (PGRMC1) in cancer biology.
Michael A Cahill, Jalal A Jazayeri, Susan M Catalano, Shinya Toyokuni, Zaklina Kovacevic

Biochim Biophys Acta· December 2016

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Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits.
Nicholas J Izzo, Agnes Staniszewski, Lillian To, Mauro Fa, Andrew F Teich, Susan M Catalano

PLoS One· July 2015

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Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity.
Nicholas J Izzo, Jinbin Xu, Chenbo Zeng, Molly J Kirk, Kelsie Mozzoni, Susan M Catalano

PLoS One· July 2015

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Discovery and development of an aurora kinase inhibitor clinical candidate using an image-based assay for measuring proliferation, apoptosis, and DNA content.
Susan M Catalano, John McLaughlin, Yasumichi Hitoshi, Don Payan

Assay Drug Dev Technol· April 2009

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Discovery of ADDL--targeting small molecule drugs for Alzheimer's disease.
Gary C Look, Jasna Jerecic, Diana B Cherbavaz, Todd R Pray, Jean-Claude R Breach, Susan M Catalano

Curr Alzheimer Res· December 2007

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The role of amyloid-beta derived diffusible ligands (ADDLs) in Alzheimer's disease.
Susan M Catalano, Elizabeth C Dodson, Darrell A Henze, Joseph G Joyce, Grant A Krafft

Curr Top Med Chem· August 2006

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Cellular interacting proteins of functional screen-derived antiproliferative and cytotoxic peptides discovered using shotgun peptide sequencing.
Tarikere Gururaja, Weiqun Li, Susan Catalano, Jakob Bogenberger, Jing Zheng

Chem Biol· October 2003

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Cellular localization and antiproliferative effect of peptides discovered from a functional screen of a retrovirally delivered random peptide library.
Yasumichi Hitoshi, Tarikere Gururaja, Denise M Pearsall, Wayne Lang, Poonam Sharma, Susan M Catalano

Chem Biol· October 2003

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