Publications by authors named "Tai-an Lin"

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Synthesis and biological evaluation of biaryl alkyl ethers as inhibitors of IDO1.
Jay A Markwalder, Aaron J Balog, David K Williams, Susheel J Nara, Ratnakar Reddy, Tai-An Lin

Bioorg Med Chem Lett· May 2023

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Current and emerging therapies for Achondroplasia: The dawn of precision medicine.
Etienne Dardenne, Noboru Ishiyama, Tai-An Lin, Matthew C Lucas

Bioorg Med Chem· May 2023

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Quantification of Linrodostat and its metabolites: Overcoming bioanalytical challenges in support of a discovery Indoleamine 2,3 dioxygenase program.
Lorell N Discenza, Aaron Balog, Christine Huang, Robin Moore, Asoka Ranasinghe, Tai-An Lin

J Chromatogr B Analyt Technol Biomed Life Sci· September 2022

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Conformational-Analysis-Guided Discovery of 2,3-Disubstituted Pyridine IDO1 Inhibitors.
Emily C Cherney, Liping Zhang, Weiwei Guo, Audris Huang, David Williams, Tai-An Lin

ACS Med Chem Lett· July 2021

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Preclinical Characterization of Linrodostat Mesylate, a Novel, Potent, and Selective Oral Indoleamine 2,3-Dioxygenase 1 Inhibitor.
Aaron Balog, Tai-An Lin, Derrick Maley, Johnni Gullo-Brown, Enzo Hamza Kandoussi

Mol Cancer Ther· March 2021

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Discovery of Imidazopyridines as Potent Inhibitors of Indoleamine 2,3-Dioxygenase 1 for Cancer Immunotherapy.
Liping Zhang, Emily C Cherney, Xiao Zhu, Tai-An Lin, Johnni Gullo-Brown

ACS Med Chem Lett· March 2021

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Discovery and Preclinical Evaluation of BMS-986242, a Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1.
Emily C Cherney, Liping Zhang, Susheel Nara, Xiao Zhu, Johnni Gullo-Brown, Tai-An Lin

ACS Med Chem Lett· February 2021

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CD40L-Dependent Pathway Is Active at Various Stages of Rheumatoid Arthritis Disease Progression.
Yanxia Guo, Alice M Walsh, Ursula Fearon, Malcolm D Smith, Mihir D Wechalekar, Tai-An Lin

J Immunol· June 2017

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Discovery of siRNA lipid nanoparticles to transfect suspension leukemia cells and provide in vivo delivery capability.
Wei He, Michael J Bennett, Leopoldo Luistro, Daisy Carvajal, Thomas Nevins, Tai-An Lin

Mol Ther· February 2014

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RG7212 anti-TWEAK mAb inhibits tumor growth through inhibition of tumor cell proliferation and survival signaling and by enhancing the host antitumor immune response.
Xuefeng Yin, Leopoldo Luistro, Hua Zhong, Melissa Smith, Tom Nevins, Tai-An Lin

Clin Cancer Res· October 2013

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Modulation of cofilin phosphorylation by inhibition of the Lim family kinases.
Liqi He, Steven P Seitz, George L Trainor, David Tortolani, Wayne Vaccaro, Tai-An Lin

Bioorg Med Chem Lett· September 2012

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The mRNA level of Charcot-Leyden crystal protein/galectin-10 is a marker for CRTH2 activation in human whole blood in vitro.
Tai-An Lin, Galina Kourteva, Holly Hilton, Hongli Li, Nadine S Tare

Biomarkers· November 2010

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KU812 cells provide a novel in vitro model of the human IL-33/ST2L axis: functional responses and identification of signaling pathways.
Nadine Tare, Hongli Li, Andrew Morschauser, Javier Cote-Sierra, Grace Ju, Tai-An Lin

Exp Cell Res· September 2010

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Cellular and molecular characterization of ozone-induced pulmonary inflammation in the Cynomolgus monkey.
Alexandra Hicks, Galina Kourteva, Holly Hilton, Hongli Li, Tai-An Lin

Inflammation· June 2010

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Influence of family communication structure and vanity trait on consumption behavior: a case study of adolescent students in Taiwan.
Wei-Lung Chang, Hsiang-Te Liu, Tai-An Lin, Yung-Sung Wen

Adolescence· November 2008

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Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors.
Petra Ross-Macdonald, Heshani de Silva, Qi Guo, Hong Xiao, Chen-Yi Hung, Tai-an Lin

Mol Cancer Ther· November 2008

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The androgen receptor can signal through Wnt/beta-Catenin in prostate cancer cells as an adaptation mechanism to castration levels of androgens.
Liang Schweizer, Cheryl A Rizzo, Thomas E Spires, J Suso Platero, Qiuyan Wu, Tai-An Lin

BMC Cell Biol· January 2008

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Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors.
Jagabandhu Das, Joseph A Furch, Chunjian Liu, Robert V Moquin, James Lin, Tai-An Lin

Bioorg Med Chem Lett· July 2006

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Discovery and SAR of 2-amino-5-[(thiomethyl)aryl]thiazoles as potent and selective Itk inhibitors.
Jagabandhu Das, Chunjian Liu, Robert V Moquin, James Lin, Joseph A Furch, Tai-An Lin

Bioorg Med Chem Lett· May 2006

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Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity.
Mark Wittman, Joan Carboni, Ricardo Attar, Balu Balasubramanian, Praveen Balimane, Tai-An Lin

J Med Chem· September 2005

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Selective Itk inhibitors block T-cell activation and murine lung inflammation.
Tai-An Lin, Kim W McIntyre, Jagabandhu Das, Chunjian Liu, Kathleen D O'Day, James Lin

Biochemistry· August 2004

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The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin.
Lloyd P McMahon, Kin M Choi, Tai-An Lin, Robert T Abraham, John C Lawrence

Mol Cell Biol· November 2002

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Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav.
Juan J Perez-Villar, Gena S Whitney, Mitchell T Sitnick, Robert J Dunn, Srividhya Venkatesan, Tai-An Lin

Biochemistry· August 2002

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Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56(Lck).
Ping Chen, Derek Norris, Edwin J Iwanowicz, Steven H Spergel, James Lin, Tai-An Lin, Donna A Bassolino

Bioorg Med Chem Lett· May 2002

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