Publications by authors named "Terry Van Vleet"

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Investigation of bone toxicity in drug development: review of current and emerging technologies.
Anik Tuladhar, Magali Guffroy, Sjoerd J Finnema, Romy Christmann, Terry R Van Vleet

Toxicol Sci· December 2025

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Pharmaceutical industry perspective on the utility of animal cell-based microphysiological systems to support human drug development.
Patrick J Devine, Jason Ekert, Anna K Kopec, David M Stresser, Diane Ramsden, Terry R Van Vleet

ALTEX· October 2025

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Rat and dog quad-culture liver chip models: characterization and use to interrogate a potential flavin-containing monooxygenase-mediated, species-specific toxicity of a histamine receptor antagonist.
David A Kukla, Tatiana A Sharapova, Rita Ciurlionis, Terry Van Vleet, Jill M Wetter

Toxicol Sci· October 2025

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Application of new approach methodologies for nonclinical safety assessment of drug candidates.
Mario Beilmann, Karissa Adkins, Harrie C M Boonen, Philip Hewitt, Wenyue Hu, Terry van Vleet

Nat Rev Drug Discov· September 2025

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Considerations from an International Regulatory and Pharmaceutical Industry (IQ MPS Affiliate) Workshop on the Standardization of Complex In Vitro Models in Drug Development.
Lindsay Tomlinson, Diane Ramsden, Sofia Batista Leite, Sonja Beken, Jessica A Bonzo, Terry R Van Vleet

Adv Biol (Weinh)· August 2024

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Towards in vitro models for reducing or replacing the use of animals in drug testing.
David M Stresser, Anna K Kopec, Philip Hewitt, Rhiannon N Hardwick, Terry R Van Vleet

Nat Biomed Eng· August 2024

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Urinary MicroRNA biomarkers of nephrotoxicity in Macaca fascicularis.
Subham Dasgupta, Tatiana Sharapova, Prathap K Mahalingaiah, Brian N Chorley, Ahmed Shoieb, Terry R van Vleet

Regul Toxicol Pharmacol· August 2024

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The Current Status and Use of Microphysiological Systems by the Pharmaceutical Industry: The International Consortium for Innovation and Quality Microphysiological Systems Affiliate Survey and Commentary.
Thomas K Baker, Terry R Van Vleet, Prathap Kumar Mahalingaiah, Taraka Sai Pavan Grandhi, Raymond Evers

Drug Metab Dispos· February 2024

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Off-target pharmacological activity at various kinases: Potential functional and pathological side effects.
Jonathon R Green, Prathap Kumar S Mahalingaiah, Sujatha M Gopalakrishnan, Michael J Liguori, Scott W Mittelstadt, Terry R Van Vleet

J Pharmacol Toxicol Methods· November 2023

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Editorial: Advances in alternative methods in preclinical pharmacology and toxicology.
Andresa Heemann Betti, John Gerry Kenna, Terry R Van Vleet, Palanisamy Aruselvan, Liz Girardi Müller

Front Pharmacol· July 2023

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Disconnect between COX-2 selective inhibition and cardiovascular risk in preclinical models.
Yevgeniya E Koshman, Aimee L Bielinski, Brandan M Bird, Jonathon R Green, Kenneth L Kowalkowski, Terry R Van Vleet

J Pharmacol Toxicol Methods· March 2023

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Preclinical species gene expression database: Development and meta-analysis.
Caitlin Krause, Kinga Suwada, Eric A G Blomme, Kenneth Kowalkowski, Michael J Liguori, Terry R Van Vleet

Front Genet· January 2023

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Perspectives on the evaluation and adoption of complex in vitro models in drug development: Workshop with the FDA and the pharmaceutical industry (IQ MPS Affiliate).
Szczepan W Baran, Paul C Brown, Andreas R Baudy, Suzanne C Fitzpatrick, Christopher Frantz, Terry Van Vleet

ALTEX· April 2022

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Nonclinical safety assessment of epigenetic modulatory drugs: Current status and industry perspective.
Vincent L Reynolds, Paul Butler, Matthew M Abernathy, Laura Aschenbrenner, Derek D Best, Terry Van Vleet

Regul Toxicol Pharmacol· November 2020

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Microphysiological Systems: A Pathologist's Perspective.
Radhakrishna Sura, Terry Van Vleet, Brian R Berridge

Vet Pathol· May 2020

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Introduction to a manuscript series on the characterization and use of microphysiological systems (MPS) in pharmaceutical safety and ADME applications.
Kristin Fabre, Brian Berridge, William R Proctor, Sherry Ralston, Yvonne Will, Terry R Van Vleet

Lab Chip· March 2020

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A pharmaceutical industry perspective on microphysiological kidney systems for evaluation of safety for new therapies.
Jonathan A Phillips, Taraka Sai Pavan Grandhi, Myrtle Davis, Jean-Charles Gautier, Niresh Hariparsad, Terry R Van Vleet

Lab Chip· February 2020

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An Overview of Machine Learning and Big Data for Drug Toxicity Evaluation.
Andy H Vo, Terry R Van Vleet, Rishi R Gupta, Michael J Liguori, Mohan S Rao

Chem Res Toxicol· January 2020

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Liver microphysiological systems development guidelines for safety risk assessment in the pharmaceutical industry.
Andreas R Baudy, Monicah A Otieno, Philip Hewitt, Jinping Gan, Adrian Roth, Terry R Van Vleet

Lab Chip· January 2020

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Potential mechanisms of target-independent uptake and toxicity of antibody-drug conjugates.
Prathap Kumar Mahalingaiah, Rita Ciurlionis, Kenneth R Durbin, Ronnie L Yeager, Binu K Philip, Terry R Van Vleet

Pharmacol Ther· August 2019

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Novel Computational Approach to Predict Off-Target Interactions for Small Molecules.
Mohan S Rao, Rishi Gupta, Michael J Liguori, Mufeng Hu, Xin Huang, Terry R Van Vleet

Front Big Data· July 2019

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Increased stress associated with head-out plethysmography testing can exacerbate respiratory effects and lead to mortality in rats.
James J Lynch, Emilie Rossignol, Joerg J Moehrle, Terry R Van Vleet, Kennan C Marsh

J Pharmacol Toxicol Methods· May 2019

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Screening Strategies and Methods for Better Off-Target Liability Prediction and Identification of Small-Molecule Pharmaceuticals.
Terry R Van Vleet, Michael J Liguori, James J Lynch, Mohan Rao, Scott Warder

SLAS Discov· January 2019

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Comparison of RNA-Seq and Microarray Gene Expression Platforms for the Toxicogenomic Evaluation of Liver From Short-Term Rat Toxicity Studies.
Mohan S Rao, Terry R Van Vleet, Rita Ciurlionis, Wayne R Buck, Scott W Mittelstadt

Front Genet· January 2019

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An In Vitro Model of Hematotoxicity: Differentiation of Bone Marrow-Derived Stem/Progenitor Cells into Hematopoietic Lineages and Evaluation of Lineage-Specific Hematotoxicity.
Prathap Kumar Mahalingaiah, Tammy Palenski, Terry R Van Vleet

Curr Protoc Toxicol· May 2018

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