Publications by authors named "Thomas Darton"

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Typhoid toxin of Salmonella Typhi elicits host antimicrobial response during acute typhoid fever.
Salma Srour, Francesca K Brown, James W Sheffield, Mohamed ElGhazaly, Daniel O'Connor, Thomas C Darton

EMBO Mol Med· December 2025

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Improving Recognition of Secondary Hemophagocytic Lymphohistiocytosis (HLH) through a Ferritin-Based Automated Alert: An Interrupted Time Series Analysis.
Jack W Goodall, Thomas G Nadin, Bethan S Lloyd Jones, Otto C Willan, Adam C Lomas, Thomas C Darton

Clin Chem· December 2025

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A systematic review of asymptomatic colonisation with Group A Streptococcus in lower- and middle-income countries.
Hermaleigh Townsley, Thomas E Locke, Nicholas Laundy, Christopher Keil, Alexander J Keeley, Thomas C Darton

J Infect· October 2025

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Leveraging paired serology to estimate the incidence of typhoidal Salmonella infection in the STRATAA study.
Jo Walker, Paula Russell, Leanne Kermack, Tan Trinh Van, Tran Vu Thieu Nga, Thomas C Darton

PLoS Negl Trop Dis· October 2025

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Safety, Efficacy, and Immunogenicity of a Salmonella Paratyphi A Vaccine.
Naina McCann, Margarete Paganotti Vicentine, Narges Ebrahimi, Melanie Greenland, Brian Angus, Thomas Darton

N Engl J Med· October 2025

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HIV status and the risk of typhoid fever and iNTS: A systematic review and meta-analysis.
Peter I Johnston, Wankumbu Chisala, Adam Hinchcliffe, Chipiliro Mhango, Ndaru Jambo, Thomas C Darton

J Infect· September 2025

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Development of a live-attenuated vaccine challenge model of Yersinia pestis in humans: Expert consultation on clinical trial considerations, January 2025.
Anna Rydlova, Emma Smith, Arabella Stuart, Robin Shattock, Tim Brooks, Thomas C Darton

Vaccine· August 2025

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Interplay between the gut microbiome and typhoid fever: insights from endemic countries and a controlled human infection model.
Philip M Ashton, Leonardos Mageiros, James E Meiring, Angeziwa Chunga-Chirambo, Farhana Khanam, Thomas C Darton

Microbiome· July 2025

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Prevalence and risk factors for Staphylococcus aureus colonisation among healthy individuals in low- and middle-income countries: A systematic review and meta-analysis.
Thomas E Locke, Alexander J Keeley, Nicholas Laundy, Christopher Keil, Jean Hamilton, Thomas C Darton

J Infect· April 2025

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Infectious diseases burden and antibiotic prescribing patterns among primary care patients in Harare, Zimbabwe - a cross-sectional analysis.
Ioana D Olaru, Rudo M S Chingono, Fadzaishe Mhino, Celia Gregson, Christian Bottomley, Thomas C Darton

PLOS Glob Public Health· April 2025

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Molecular Methods Enhance the Detection of Pyoderma-Related Streptococcus pyogenes and emm-Type Distribution in Children.
Jennifer N Hall, Edwin P Armitage, Elina Senghore, Saffiatou Darboe, Momodou Barry, Thomas C Darton

J Infect Dis· February 2025

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Microfluidic qPCR for detection of 21 common respiratory viruses in children with influenza-like illness.
Thomas J Saville, Hayley Colton, Sheikh Jarju, Edwin P Armitage, Sainabou Drammeh, Thomas C Darton

Sci Rep· November 2024

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Changes in monocyte subsets in volunteers who received an oral wild-type Typhi challenge and reached typhoid diagnosis criteria.
Franklin R Toapanta, Jingping Hu, Kari Ann Shirey, Paula J Bernal, Myron M Levine, Thomas C Darton

Front Immunol· September 2024

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Role of circulating T follicular helper subsets following Ty21a immunization and oral challenge with wild type . Typhi in humans.
Jayaum S Booth, Rekha R Rapaka, Monica A McArthur, Stephanie Fresnay, Thomas C Darton

Front Immunol· September 2024

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Less is more: Uptake of recommended vaccines in a UK travel clinic.
Thomas Harrison, Jacqueline Clark, Thomas C Darton

J Infect· March 2024

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The immune evasion roles of protein A and impact on vaccine development.
Alex Bear, Thomas Locke, Sarah Rowland-Jones, Simone Pecetta, Fabio Bagnoli, Thomas C Darton

Front Cell Infect Microbiol· November 2023

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Seasonal Azithromycin Use in Paediatric Protracted Bacterial Bronchitis Does Not Promote Antimicrobial Resistance but Does Modulate the Nasopharyngeal Microbiome.
Simon J Hardman, Fiona M Shackley, Kelechi Ugonna, Thomas C Darton, Alan S Rigby

Int J Mol Sci· November 2023

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Early transcriptional responses to human enteric fever challenge.
Amber Barton, Jennifer Hill, Daniel O'Connor, Claire Jones, Elizabeth Jones, Thomas C Darton

Infect Immun· October 2023

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Omicron BA.1-containing mRNA-1273 boosters compared with the original COVID-19 vaccine in the UK: a randomised, observer-blind, active-controlled trial.
Ivan T Lee, Catherine A Cosgrove, Patrick Moore, Claire Bethune, Rhiannon Nally, Thomas C Darton

Lancet Infect Dis· September 2023

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The effect of a comprehensive typhoid conjugate vaccine campaign on antimicrobial prescribing in children in Harare, Zimbabwe: a mixed methods study.
Ioana D Olaru, Rudo M S Chingono, Christian Bottomley, Faith R Kandiye, Fadzaishe Mhino, Thomas C Darton

Lancet Glob Health· September 2023

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The Challenge Non-Typhoidal (CHANTS) Consortium: Development of a non-typhoidal controlled human infection model: Report from a consultation group workshop, 05 July 2022, London, UK.
Christopher Smith, Emma Smith, Christopher Chiu, Jay Hinton, Blanca Perez Sepulveda, Thomas C Darton

Wellcome Open Res· September 2023

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Bacterial shedding and serologic responses following an outbreak of Salmonella Typhi in an endemic cohort.
Peter I Johnston, Patrick Bogue, Angeziwa Chunga Chirambo, Maurice Mbewe, Reenesh Prakash, Thomas Darton

BMC Infect Dis· June 2023

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Characterizing altruistic motivation in potential volunteers for SARS-CoV-2 challenge trials.
Abigail A Marsh, Monica Magalhaes, Matthew Peeler, Sophie M Rose, Thomas C Darton

PLoS One· November 2022

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Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins.
Rebecca Kuehn, Nicole Stoesser, David Eyre, Thomas C Darton, Buddha Basnyat

Cochrane Database Syst Rev· November 2022

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Clinical and laboratory factors associated with neonatal sepsis mortality at a major Vietnamese children's hospital.
Nguyen Duc Toan, Thomas C Darton, Nguyen Hoang Thien Huong, Le Thanh Hoang Nhat, To Nguyen Thi Nguyen

PLOS Glob Public Health· September 2022

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